Epistatic regulation of growth in Atlantic salmon revealed: a QTL study performed on the domesticated-wild interface
BACKGROUND: Quantitative traits are typically considered to be under additive genetic control. Although there are indications that non-additive factors have the potential to contribute to trait variation, experimental demonstration remains scarce. Here, we investigated the genetic basis of growth in...
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ftpubmed:oai:pubmedcentral.nih.gov:7006396 2023-05-15T15:30:57+02:00 Epistatic regulation of growth in Atlantic salmon revealed: a QTL study performed on the domesticated-wild interface Besnier, Francois Solberg, Monica F. Harvey, Alison C. Carvalho, Gary R. Bekkevold, Dorte Taylor, Martin I. Creer, Simon Nielsen, Einar E. Skaala, Øystein Ayllon, Fernando Dahle, Geir Glover, Kevin A. 2020-02-07 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006396/ http://www.ncbi.nlm.nih.gov/pubmed/32033538 https://doi.org/10.1186/s12863-020-0816-y en eng BioMed Central http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006396/ http://www.ncbi.nlm.nih.gov/pubmed/32033538 http://dx.doi.org/10.1186/s12863-020-0816-y © The Author(s). 2020 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. CC0 PDM CC-BY Research Article Text 2020 ftpubmed https://doi.org/10.1186/s12863-020-0816-y 2020-02-16T01:31:10Z BACKGROUND: Quantitative traits are typically considered to be under additive genetic control. Although there are indications that non-additive factors have the potential to contribute to trait variation, experimental demonstration remains scarce. Here, we investigated the genetic basis of growth in Atlantic salmon by exploiting the high level of genetic diversity and trait expression among domesticated, hybrid and wild populations. RESULTS: After rearing fish in common-garden experiments under aquaculture conditions, we performed a variance component analysis in four mapping populations totaling ~ 7000 individuals from six wild, two domesticated and three F1 wild/domesticated hybrid strains. Across the four independent datasets, genome-wide significant quantitative trait loci (QTLs) associated with weight and length were detected on a total of 18 chromosomes, reflecting the polygenic nature of growth. Significant QTLs correlated with both length and weight were detected on chromosomes 2, 6 and 9 in multiple datasets. Significantly, epistatic QTLs were detected in all datasets. DISCUSSION: The observed interactions demonstrated that the phenotypic effect of inheriting an allele deviated between half-sib families. Gene-by-gene interactions were also suggested, where the combined effect of two loci resulted in a genetic effect upon phenotypic variance, while no genetic effect was detected when the two loci were considered separately. To our knowledge, this is the first documentation of epistasis in a quantitative trait in Atlantic salmon. These novel results are of relevance for breeding programs, and for predicting the evolutionary consequences of domestication-introgression in wild populations. Text Atlantic salmon PubMed Central (PMC) BMC Genetics 21 1 |
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Research Article Besnier, Francois Solberg, Monica F. Harvey, Alison C. Carvalho, Gary R. Bekkevold, Dorte Taylor, Martin I. Creer, Simon Nielsen, Einar E. Skaala, Øystein Ayllon, Fernando Dahle, Geir Glover, Kevin A. Epistatic regulation of growth in Atlantic salmon revealed: a QTL study performed on the domesticated-wild interface |
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Research Article |
description |
BACKGROUND: Quantitative traits are typically considered to be under additive genetic control. Although there are indications that non-additive factors have the potential to contribute to trait variation, experimental demonstration remains scarce. Here, we investigated the genetic basis of growth in Atlantic salmon by exploiting the high level of genetic diversity and trait expression among domesticated, hybrid and wild populations. RESULTS: After rearing fish in common-garden experiments under aquaculture conditions, we performed a variance component analysis in four mapping populations totaling ~ 7000 individuals from six wild, two domesticated and three F1 wild/domesticated hybrid strains. Across the four independent datasets, genome-wide significant quantitative trait loci (QTLs) associated with weight and length were detected on a total of 18 chromosomes, reflecting the polygenic nature of growth. Significant QTLs correlated with both length and weight were detected on chromosomes 2, 6 and 9 in multiple datasets. Significantly, epistatic QTLs were detected in all datasets. DISCUSSION: The observed interactions demonstrated that the phenotypic effect of inheriting an allele deviated between half-sib families. Gene-by-gene interactions were also suggested, where the combined effect of two loci resulted in a genetic effect upon phenotypic variance, while no genetic effect was detected when the two loci were considered separately. To our knowledge, this is the first documentation of epistasis in a quantitative trait in Atlantic salmon. These novel results are of relevance for breeding programs, and for predicting the evolutionary consequences of domestication-introgression in wild populations. |
format |
Text |
author |
Besnier, Francois Solberg, Monica F. Harvey, Alison C. Carvalho, Gary R. Bekkevold, Dorte Taylor, Martin I. Creer, Simon Nielsen, Einar E. Skaala, Øystein Ayllon, Fernando Dahle, Geir Glover, Kevin A. |
author_facet |
Besnier, Francois Solberg, Monica F. Harvey, Alison C. Carvalho, Gary R. Bekkevold, Dorte Taylor, Martin I. Creer, Simon Nielsen, Einar E. Skaala, Øystein Ayllon, Fernando Dahle, Geir Glover, Kevin A. |
author_sort |
Besnier, Francois |
title |
Epistatic regulation of growth in Atlantic salmon revealed: a QTL study performed on the domesticated-wild interface |
title_short |
Epistatic regulation of growth in Atlantic salmon revealed: a QTL study performed on the domesticated-wild interface |
title_full |
Epistatic regulation of growth in Atlantic salmon revealed: a QTL study performed on the domesticated-wild interface |
title_fullStr |
Epistatic regulation of growth in Atlantic salmon revealed: a QTL study performed on the domesticated-wild interface |
title_full_unstemmed |
Epistatic regulation of growth in Atlantic salmon revealed: a QTL study performed on the domesticated-wild interface |
title_sort |
epistatic regulation of growth in atlantic salmon revealed: a qtl study performed on the domesticated-wild interface |
publisher |
BioMed Central |
publishDate |
2020 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006396/ http://www.ncbi.nlm.nih.gov/pubmed/32033538 https://doi.org/10.1186/s12863-020-0816-y |
genre |
Atlantic salmon |
genre_facet |
Atlantic salmon |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006396/ http://www.ncbi.nlm.nih.gov/pubmed/32033538 http://dx.doi.org/10.1186/s12863-020-0816-y |
op_rights |
© The Author(s). 2020 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
op_rightsnorm |
CC0 PDM CC-BY |
op_doi |
https://doi.org/10.1186/s12863-020-0816-y |
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BMC Genetics |
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21 |
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1 |
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1766361432176197632 |