Contrasting effects of acute and chronic stress on the transcriptome, epigenome, and immune response of Atlantic salmon
Stress experienced during early life may have lasting effects on the immune system, with impacts on health and disease dependent on the nature and duration of the stressor. The epigenome is especially sensitive to environmental stimuli during early life and represents a potential mechanism through w...
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ftpubmed:oai:pubmedcentral.nih.gov:6986783 2023-05-15T15:31:44+02:00 Contrasting effects of acute and chronic stress on the transcriptome, epigenome, and immune response of Atlantic salmon Uren Webster, Tamsyn M. Rodriguez-Barreto, Deiene Martin, Samuel A.M. Van Oosterhout, Cock Orozco-terWengel, Pablo Cable, Joanne Hamilton, Alastair Garcia De Leaniz, Carlos Consuegra, Sofia 2018-12-13 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6986783/ http://www.ncbi.nlm.nih.gov/pubmed/30526303 https://doi.org/10.1080/15592294.2018.1554520 en eng Taylor & Francis http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6986783/ http://www.ncbi.nlm.nih.gov/pubmed/30526303 http://dx.doi.org/10.1080/15592294.2018.1554520 © 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. CC-BY Research Paper Text 2018 ftpubmed https://doi.org/10.1080/15592294.2018.1554520 2020-02-16T01:18:34Z Stress experienced during early life may have lasting effects on the immune system, with impacts on health and disease dependent on the nature and duration of the stressor. The epigenome is especially sensitive to environmental stimuli during early life and represents a potential mechanism through which stress may cause long-lasting health effects. However, the extent to which the epigenome responds differently to chronic vs acute stressors is unclear, especially for non-mammalian species. We examined the effects of acute stress (cold-shock during embryogenesis) and chronic stress (absence of tank enrichment during larval-stage) on global gene expression (using RNA-seq) and DNA methylation (using RRBS) in the gills of Atlantic salmon (Salmo salar) four months after hatching. Chronic stress induced pronounced transcriptional differences, while acute stress caused few lasting transcriptional effects. However, both acute and chronic stress caused lasting and contrasting changes in the methylome. Crucially, we found that acute stress enhanced transcriptional immune response to a pathogenic challenge (bacterial lipopolysaccharide, LPS), while chronic stress suppressed it. We identified stress-induced changes in promoter and gene-body methylation that were associated with altered expression for a small proportion of immune-related genes, and evidence of wider epigenetic regulation within signalling pathways involved in immune response. Our results suggest that stress can affect immuno-competence through epigenetic mechanisms, and highlight the markedly different effects of chronic larval and acute embryonic stress. This knowledge could be used to harness the stimulatory effects of acute stress on immunity, paving the way for improved stress and disease management through epigenetic conditioning. Text Atlantic salmon Salmo salar PubMed Central (PMC) Epigenetics 13 12 1191 1207 |
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Research Paper |
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Research Paper Uren Webster, Tamsyn M. Rodriguez-Barreto, Deiene Martin, Samuel A.M. Van Oosterhout, Cock Orozco-terWengel, Pablo Cable, Joanne Hamilton, Alastair Garcia De Leaniz, Carlos Consuegra, Sofia Contrasting effects of acute and chronic stress on the transcriptome, epigenome, and immune response of Atlantic salmon |
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Research Paper |
description |
Stress experienced during early life may have lasting effects on the immune system, with impacts on health and disease dependent on the nature and duration of the stressor. The epigenome is especially sensitive to environmental stimuli during early life and represents a potential mechanism through which stress may cause long-lasting health effects. However, the extent to which the epigenome responds differently to chronic vs acute stressors is unclear, especially for non-mammalian species. We examined the effects of acute stress (cold-shock during embryogenesis) and chronic stress (absence of tank enrichment during larval-stage) on global gene expression (using RNA-seq) and DNA methylation (using RRBS) in the gills of Atlantic salmon (Salmo salar) four months after hatching. Chronic stress induced pronounced transcriptional differences, while acute stress caused few lasting transcriptional effects. However, both acute and chronic stress caused lasting and contrasting changes in the methylome. Crucially, we found that acute stress enhanced transcriptional immune response to a pathogenic challenge (bacterial lipopolysaccharide, LPS), while chronic stress suppressed it. We identified stress-induced changes in promoter and gene-body methylation that were associated with altered expression for a small proportion of immune-related genes, and evidence of wider epigenetic regulation within signalling pathways involved in immune response. Our results suggest that stress can affect immuno-competence through epigenetic mechanisms, and highlight the markedly different effects of chronic larval and acute embryonic stress. This knowledge could be used to harness the stimulatory effects of acute stress on immunity, paving the way for improved stress and disease management through epigenetic conditioning. |
format |
Text |
author |
Uren Webster, Tamsyn M. Rodriguez-Barreto, Deiene Martin, Samuel A.M. Van Oosterhout, Cock Orozco-terWengel, Pablo Cable, Joanne Hamilton, Alastair Garcia De Leaniz, Carlos Consuegra, Sofia |
author_facet |
Uren Webster, Tamsyn M. Rodriguez-Barreto, Deiene Martin, Samuel A.M. Van Oosterhout, Cock Orozco-terWengel, Pablo Cable, Joanne Hamilton, Alastair Garcia De Leaniz, Carlos Consuegra, Sofia |
author_sort |
Uren Webster, Tamsyn M. |
title |
Contrasting effects of acute and chronic stress on the transcriptome, epigenome, and immune response of Atlantic salmon |
title_short |
Contrasting effects of acute and chronic stress on the transcriptome, epigenome, and immune response of Atlantic salmon |
title_full |
Contrasting effects of acute and chronic stress on the transcriptome, epigenome, and immune response of Atlantic salmon |
title_fullStr |
Contrasting effects of acute and chronic stress on the transcriptome, epigenome, and immune response of Atlantic salmon |
title_full_unstemmed |
Contrasting effects of acute and chronic stress on the transcriptome, epigenome, and immune response of Atlantic salmon |
title_sort |
contrasting effects of acute and chronic stress on the transcriptome, epigenome, and immune response of atlantic salmon |
publisher |
Taylor & Francis |
publishDate |
2018 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6986783/ http://www.ncbi.nlm.nih.gov/pubmed/30526303 https://doi.org/10.1080/15592294.2018.1554520 |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6986783/ http://www.ncbi.nlm.nih.gov/pubmed/30526303 http://dx.doi.org/10.1080/15592294.2018.1554520 |
op_rights |
© 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1080/15592294.2018.1554520 |
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Epigenetics |
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12 |
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1191 |
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1207 |
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1766362257968594944 |