Fish skin grafts compared to human amnion/chorion membrane allografts: A double‐blind, prospective, randomized clinical trial of acute wound healing
Chronic, nonhealing wounds consume a great deal of healthcare resources and are a major public health problem, associated with high morbidity and significant economic costs. Skin grafts are commonly used to facilitate wound closure. The grafts can come from the patient's own skin (autograft), a...
Published in: | Wound Repair and Regeneration |
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Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6972637/ http://www.ncbi.nlm.nih.gov/pubmed/31509319 https://doi.org/10.1111/wrr.12761 |
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ftpubmed:oai:pubmedcentral.nih.gov:6972637 2023-05-15T15:27:47+02:00 Fish skin grafts compared to human amnion/chorion membrane allografts: A double‐blind, prospective, randomized clinical trial of acute wound healing Kirsner, Robert S. Margolis, David J. Baldursson, Baldur T. Petursdottir, Kristin Davidsson, Olafur B. Weir, Dot Lantis, John C. 2019-10-25 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6972637/ http://www.ncbi.nlm.nih.gov/pubmed/31509319 https://doi.org/10.1111/wrr.12761 en eng John Wiley & Sons, Inc. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6972637/ http://www.ncbi.nlm.nih.gov/pubmed/31509319 http://dx.doi.org/10.1111/wrr.12761 © 2019 The Authors. Wound Repair and Regeneration published by Wiley Periodicals, Inc. on behalf of by the Wound Healing Society. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. CC-BY Original Research‐Clinical Science Text 2019 ftpubmed https://doi.org/10.1111/wrr.12761 2020-02-02T01:27:35Z Chronic, nonhealing wounds consume a great deal of healthcare resources and are a major public health problem, associated with high morbidity and significant economic costs. Skin grafts are commonly used to facilitate wound closure. The grafts can come from the patient's own skin (autograft), a human donor (allograft), or from a different species (xenograft). A fish skin xenograft from cold‐water fish (Atlantic cod, Gadus morhua) is a relatively recent option that shows promising preclinical and clinical results in wound healing. Chronic wounds vary greatly in etiology and nature, requiring large cohorts for effective comparison between therapeutic alternatives. In this study, we attempted to imitate the status of a freshly debrided chronic wound by creating acute full‐thickness wounds, 4 mm in diameter, on healthy volunteers to compare two materials frequently used to treat chronic wounds: fish skin and dHACM. The purpose is to give an indication of the efficacy of the two therapeutic alternatives in the treatment of chronic wounds in a simple, standardized, randomized, controlled, double‐blind study. All volunteers were given two identical punch biopsy wounds, one of which was treated with a fish skin graft and the other with dehydrated human amnion/chorion membrane allograft (dHACM). In the study, 170 wounds were treated (85 wounds per group). The primary endpoint was defined as time to heal (full epithelialization) by blinded assessment at days 14, 18, 21, 25, and 28. The superiority hypothesis was that the fish skin grafts would heal the wounds faster than the dHACM. To evaluate the superiority hypothesis, a mixed Cox proportional hazard model was used. Wounds treated with fish skin healed significantly faster (hazard ratio 2.37; 95% confidence interval: (1.75–3.22; p = 0.0014) compared with wounds treated with dHACM. The results show that acute biopsy wounds treated with fish skin grafts heal faster than wounds treated with dHACM. Text atlantic cod Gadus morhua PubMed Central (PMC) Wound Repair and Regeneration 28 1 75 80 |
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Original Research‐Clinical Science |
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Original Research‐Clinical Science Kirsner, Robert S. Margolis, David J. Baldursson, Baldur T. Petursdottir, Kristin Davidsson, Olafur B. Weir, Dot Lantis, John C. Fish skin grafts compared to human amnion/chorion membrane allografts: A double‐blind, prospective, randomized clinical trial of acute wound healing |
topic_facet |
Original Research‐Clinical Science |
description |
Chronic, nonhealing wounds consume a great deal of healthcare resources and are a major public health problem, associated with high morbidity and significant economic costs. Skin grafts are commonly used to facilitate wound closure. The grafts can come from the patient's own skin (autograft), a human donor (allograft), or from a different species (xenograft). A fish skin xenograft from cold‐water fish (Atlantic cod, Gadus morhua) is a relatively recent option that shows promising preclinical and clinical results in wound healing. Chronic wounds vary greatly in etiology and nature, requiring large cohorts for effective comparison between therapeutic alternatives. In this study, we attempted to imitate the status of a freshly debrided chronic wound by creating acute full‐thickness wounds, 4 mm in diameter, on healthy volunteers to compare two materials frequently used to treat chronic wounds: fish skin and dHACM. The purpose is to give an indication of the efficacy of the two therapeutic alternatives in the treatment of chronic wounds in a simple, standardized, randomized, controlled, double‐blind study. All volunteers were given two identical punch biopsy wounds, one of which was treated with a fish skin graft and the other with dehydrated human amnion/chorion membrane allograft (dHACM). In the study, 170 wounds were treated (85 wounds per group). The primary endpoint was defined as time to heal (full epithelialization) by blinded assessment at days 14, 18, 21, 25, and 28. The superiority hypothesis was that the fish skin grafts would heal the wounds faster than the dHACM. To evaluate the superiority hypothesis, a mixed Cox proportional hazard model was used. Wounds treated with fish skin healed significantly faster (hazard ratio 2.37; 95% confidence interval: (1.75–3.22; p = 0.0014) compared with wounds treated with dHACM. The results show that acute biopsy wounds treated with fish skin grafts heal faster than wounds treated with dHACM. |
format |
Text |
author |
Kirsner, Robert S. Margolis, David J. Baldursson, Baldur T. Petursdottir, Kristin Davidsson, Olafur B. Weir, Dot Lantis, John C. |
author_facet |
Kirsner, Robert S. Margolis, David J. Baldursson, Baldur T. Petursdottir, Kristin Davidsson, Olafur B. Weir, Dot Lantis, John C. |
author_sort |
Kirsner, Robert S. |
title |
Fish skin grafts compared to human amnion/chorion membrane allografts: A double‐blind, prospective, randomized clinical trial of acute wound healing |
title_short |
Fish skin grafts compared to human amnion/chorion membrane allografts: A double‐blind, prospective, randomized clinical trial of acute wound healing |
title_full |
Fish skin grafts compared to human amnion/chorion membrane allografts: A double‐blind, prospective, randomized clinical trial of acute wound healing |
title_fullStr |
Fish skin grafts compared to human amnion/chorion membrane allografts: A double‐blind, prospective, randomized clinical trial of acute wound healing |
title_full_unstemmed |
Fish skin grafts compared to human amnion/chorion membrane allografts: A double‐blind, prospective, randomized clinical trial of acute wound healing |
title_sort |
fish skin grafts compared to human amnion/chorion membrane allografts: a double‐blind, prospective, randomized clinical trial of acute wound healing |
publisher |
John Wiley & Sons, Inc. |
publishDate |
2019 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6972637/ http://www.ncbi.nlm.nih.gov/pubmed/31509319 https://doi.org/10.1111/wrr.12761 |
genre |
atlantic cod Gadus morhua |
genre_facet |
atlantic cod Gadus morhua |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6972637/ http://www.ncbi.nlm.nih.gov/pubmed/31509319 http://dx.doi.org/10.1111/wrr.12761 |
op_rights |
© 2019 The Authors. Wound Repair and Regeneration published by Wiley Periodicals, Inc. on behalf of by the Wound Healing Society. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1111/wrr.12761 |
container_title |
Wound Repair and Regeneration |
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28 |
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1 |
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75 |
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80 |
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1766358199145857024 |