GWAS studies reveal a possible genetic link between cancer and suicide attempt
Inuit is the population with the highest incidence of suicide attempt and cancer in the world. Previous studies reported that people attempted suicide have a higher future risk for cancer. In view of these data, the largest available genome wide association studies (GWAS) for four major mental disor...
Published in: | Scientific Reports |
---|---|
Main Authors: | , |
Format: | Text |
Language: | English |
Published: |
Nature Publishing Group UK
2019
|
Subjects: | |
Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6892859/ http://www.ncbi.nlm.nih.gov/pubmed/31797972 https://doi.org/10.1038/s41598-019-54812-9 |
id |
ftpubmed:oai:pubmedcentral.nih.gov:6892859 |
---|---|
record_format |
openpolar |
spelling |
ftpubmed:oai:pubmedcentral.nih.gov:6892859 2023-05-15T16:55:11+02:00 GWAS studies reveal a possible genetic link between cancer and suicide attempt Voskarides, Konstantinos Chatzittofis, Andreas 2019-12-04 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6892859/ http://www.ncbi.nlm.nih.gov/pubmed/31797972 https://doi.org/10.1038/s41598-019-54812-9 en eng Nature Publishing Group UK http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6892859/ http://www.ncbi.nlm.nih.gov/pubmed/31797972 http://dx.doi.org/10.1038/s41598-019-54812-9 © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. CC-BY Article Text 2019 ftpubmed https://doi.org/10.1038/s41598-019-54812-9 2019-12-15T01:38:36Z Inuit is the population with the highest incidence of suicide attempt and cancer in the world. Previous studies reported that people attempted suicide have a higher future risk for cancer. In view of these data, the largest available genome wide association studies (GWAS) for four major mental disorder groups were screened here for any common genes with all known cancer associated genes and oncogenes/tumor suppressor genes. A common genetic background came out only between suicide attempt and cancer (cancer associated genes analysis: RR = 1.64, p = 7.83 × 10(−5); oncogenes/tumor suppressor genes analysis: RR = 2.55, p = 2.82 × 10(−22)), this supporting existing epidemiological data. Incidence/prevalence of both conditions was found to correlate with extreme cold geographical regions (adjusted R(2) = 0.135, p = 3.00 × 10(−4)); this is not the case for other mental disorders. Our results show a possible genetic link between suicide attempt and cancer and a possible evolutionary connection of both diseases with extreme cold environments. These data are useful for future molecular studies or even for investigation of possible therapeutic protocols. Text inuit PubMed Central (PMC) Scientific Reports 9 1 |
institution |
Open Polar |
collection |
PubMed Central (PMC) |
op_collection_id |
ftpubmed |
language |
English |
topic |
Article |
spellingShingle |
Article Voskarides, Konstantinos Chatzittofis, Andreas GWAS studies reveal a possible genetic link between cancer and suicide attempt |
topic_facet |
Article |
description |
Inuit is the population with the highest incidence of suicide attempt and cancer in the world. Previous studies reported that people attempted suicide have a higher future risk for cancer. In view of these data, the largest available genome wide association studies (GWAS) for four major mental disorder groups were screened here for any common genes with all known cancer associated genes and oncogenes/tumor suppressor genes. A common genetic background came out only between suicide attempt and cancer (cancer associated genes analysis: RR = 1.64, p = 7.83 × 10(−5); oncogenes/tumor suppressor genes analysis: RR = 2.55, p = 2.82 × 10(−22)), this supporting existing epidemiological data. Incidence/prevalence of both conditions was found to correlate with extreme cold geographical regions (adjusted R(2) = 0.135, p = 3.00 × 10(−4)); this is not the case for other mental disorders. Our results show a possible genetic link between suicide attempt and cancer and a possible evolutionary connection of both diseases with extreme cold environments. These data are useful for future molecular studies or even for investigation of possible therapeutic protocols. |
format |
Text |
author |
Voskarides, Konstantinos Chatzittofis, Andreas |
author_facet |
Voskarides, Konstantinos Chatzittofis, Andreas |
author_sort |
Voskarides, Konstantinos |
title |
GWAS studies reveal a possible genetic link between cancer and suicide attempt |
title_short |
GWAS studies reveal a possible genetic link between cancer and suicide attempt |
title_full |
GWAS studies reveal a possible genetic link between cancer and suicide attempt |
title_fullStr |
GWAS studies reveal a possible genetic link between cancer and suicide attempt |
title_full_unstemmed |
GWAS studies reveal a possible genetic link between cancer and suicide attempt |
title_sort |
gwas studies reveal a possible genetic link between cancer and suicide attempt |
publisher |
Nature Publishing Group UK |
publishDate |
2019 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6892859/ http://www.ncbi.nlm.nih.gov/pubmed/31797972 https://doi.org/10.1038/s41598-019-54812-9 |
genre |
inuit |
genre_facet |
inuit |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6892859/ http://www.ncbi.nlm.nih.gov/pubmed/31797972 http://dx.doi.org/10.1038/s41598-019-54812-9 |
op_rights |
© The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1038/s41598-019-54812-9 |
container_title |
Scientific Reports |
container_volume |
9 |
container_issue |
1 |
_version_ |
1766046167600201728 |