Omega-3 Polyunsaturated Fatty Acids and Stroke Burden
Stroke is a major leading cause of death and disability worldwide. N-3 polyunsaturated fatty acids (PUFAs) including eicosapentaenoic acid and docosahexaenoic acid have potent anti-inflammatory effects, reduce platelet aggregation, and regress atherosclerotic plaques. Since the discovery that the Gr...
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ftpubmed:oai:pubmedcentral.nih.gov:6888676 2023-05-15T16:07:07+02:00 Omega-3 Polyunsaturated Fatty Acids and Stroke Burden Ueno, Yuji Miyamoto, Nobukazu Yamashiro, Kazuo Tanaka, Ryota Hattori, Nobutaka 2019-11-07 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6888676/ http://www.ncbi.nlm.nih.gov/pubmed/31703271 https://doi.org/10.3390/ijms20225549 en eng MDPI http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6888676/ http://www.ncbi.nlm.nih.gov/pubmed/31703271 http://dx.doi.org/10.3390/ijms20225549 © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). CC-BY Review Text 2019 ftpubmed https://doi.org/10.3390/ijms20225549 2019-12-15T01:31:21Z Stroke is a major leading cause of death and disability worldwide. N-3 polyunsaturated fatty acids (PUFAs) including eicosapentaenoic acid and docosahexaenoic acid have potent anti-inflammatory effects, reduce platelet aggregation, and regress atherosclerotic plaques. Since the discovery that the Greenland Eskimo population, whose diet is high in marine n-3 PUFAs, have a lower incidence of coronary heart disease than Western populations, numerous epidemiological studies to explore the associations of dietary intakes of fish and n-3 PUFAs with cardiovascular diseases, and large-scale clinical trials to identify the benefits of treatment with n-3 PUFAs have been conducted. In most of these studies the incidence and mortality of stroke were also evaluated mainly as secondary endpoints. Thus, a systematic literature review regarding the association of dietary intake of n-3 PUFAs with stroke in the epidemiological studies and the treatment effects of n-3 PUFAs in the clinical trials was conducted. Moreover, recent experimental studies were also reviewed to explore the molecular mechanisms of the neuroprotective effects of n-3 PUFAs after stroke. Text eskimo* Greenland PubMed Central (PMC) Greenland International Journal of Molecular Sciences 20 22 5549 |
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Review Ueno, Yuji Miyamoto, Nobukazu Yamashiro, Kazuo Tanaka, Ryota Hattori, Nobutaka Omega-3 Polyunsaturated Fatty Acids and Stroke Burden |
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Review |
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Stroke is a major leading cause of death and disability worldwide. N-3 polyunsaturated fatty acids (PUFAs) including eicosapentaenoic acid and docosahexaenoic acid have potent anti-inflammatory effects, reduce platelet aggregation, and regress atherosclerotic plaques. Since the discovery that the Greenland Eskimo population, whose diet is high in marine n-3 PUFAs, have a lower incidence of coronary heart disease than Western populations, numerous epidemiological studies to explore the associations of dietary intakes of fish and n-3 PUFAs with cardiovascular diseases, and large-scale clinical trials to identify the benefits of treatment with n-3 PUFAs have been conducted. In most of these studies the incidence and mortality of stroke were also evaluated mainly as secondary endpoints. Thus, a systematic literature review regarding the association of dietary intake of n-3 PUFAs with stroke in the epidemiological studies and the treatment effects of n-3 PUFAs in the clinical trials was conducted. Moreover, recent experimental studies were also reviewed to explore the molecular mechanisms of the neuroprotective effects of n-3 PUFAs after stroke. |
format |
Text |
author |
Ueno, Yuji Miyamoto, Nobukazu Yamashiro, Kazuo Tanaka, Ryota Hattori, Nobutaka |
author_facet |
Ueno, Yuji Miyamoto, Nobukazu Yamashiro, Kazuo Tanaka, Ryota Hattori, Nobutaka |
author_sort |
Ueno, Yuji |
title |
Omega-3 Polyunsaturated Fatty Acids and Stroke Burden |
title_short |
Omega-3 Polyunsaturated Fatty Acids and Stroke Burden |
title_full |
Omega-3 Polyunsaturated Fatty Acids and Stroke Burden |
title_fullStr |
Omega-3 Polyunsaturated Fatty Acids and Stroke Burden |
title_full_unstemmed |
Omega-3 Polyunsaturated Fatty Acids and Stroke Burden |
title_sort |
omega-3 polyunsaturated fatty acids and stroke burden |
publisher |
MDPI |
publishDate |
2019 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6888676/ http://www.ncbi.nlm.nih.gov/pubmed/31703271 https://doi.org/10.3390/ijms20225549 |
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Greenland |
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Greenland |
genre |
eskimo* Greenland |
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eskimo* Greenland |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6888676/ http://www.ncbi.nlm.nih.gov/pubmed/31703271 http://dx.doi.org/10.3390/ijms20225549 |
op_rights |
© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
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CC-BY |
op_doi |
https://doi.org/10.3390/ijms20225549 |
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International Journal of Molecular Sciences |
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20 |
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22 |
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5549 |
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