Introgression drives repeated evolution of winter coat color polymorphism in hares
Changing from summer-brown to winter-white pelage or plumage is a crucial adaptation to seasonal snow in more than 20 mammal and bird species. Many of these species maintain nonwhite winter morphs, locally adapted to less snowy conditions, which may have evolved independently. Mountain hares (Lepus...
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ftpubmed:oai:pubmedcentral.nih.gov:6883779 2023-05-15T16:10:58+02:00 Introgression drives repeated evolution of winter coat color polymorphism in hares Giska, Iwona Farelo, Liliana Pimenta, João Seixas, Fernando A. Ferreira, Mafalda S. Marques, João P. Miranda, Inês Letty, Jérôme Jenny, Hannes Hackländer, Klaus Magnussen, Eyðfinn Melo-Ferreira, José 2019-11-26 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883779/ http://www.ncbi.nlm.nih.gov/pubmed/31712446 https://doi.org/10.1073/pnas.1910471116 en eng National Academy of Sciences http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883779/ http://www.ncbi.nlm.nih.gov/pubmed/31712446 http://dx.doi.org/10.1073/pnas.1910471116 https://www.pnas.org/site/aboutpnas/licenses.xhtmlPublished under the PNAS license (https://www.pnas.org/site/aboutpnas/licenses.xhtml) . Proc Natl Acad Sci U S A Biological Sciences Text 2019 ftpubmed https://doi.org/10.1073/pnas.1910471116 2020-05-17T00:16:04Z Changing from summer-brown to winter-white pelage or plumage is a crucial adaptation to seasonal snow in more than 20 mammal and bird species. Many of these species maintain nonwhite winter morphs, locally adapted to less snowy conditions, which may have evolved independently. Mountain hares (Lepus timidus) from Fennoscandia were introduced into the Faroe Islands in 1855. While they were initially winter-white, within ∼65 y all Faroese hares became winter-gray, a morph that occurs in the source population at low frequency. The documented population history makes this a valuable model for understanding the genetic basis and evolution of the seasonal trait polymorphism. Through whole-genome scans of differentiation and single-nucleotide polymorphism (SNP) genotyping, we associated winter coat color polymorphism to the genomic region of the pigmentation gene Agouti, previously linked to introgression-driven winter coat color variation in the snowshoe hare (Lepus americanus). Lower Agouti expression in the skin of winter-gray individuals during the autumn molt suggests that regulatory changes may underlie the color polymorphism. Variation in the associated genomic region shows signatures of a selective sweep in the Faroese population, suggesting that positive selection drove the fixation of the variant after the introduction. Whole-genome analyses of several hare species revealed that the winter-gray variant originated through introgression from a noncolor changing species, in keeping with the history of ancient hybridization between the species. Our findings show the recurrent role of introgression in generating winter coat color variation by repeatedly recruiting the regulatory region of Agouti to modulate seasonal coat color change. Text Faroe Islands Fennoscandia Lepus timidus PubMed Central (PMC) Faroe Islands Proceedings of the National Academy of Sciences 116 48 24150 24156 |
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language |
English |
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Biological Sciences |
spellingShingle |
Biological Sciences Giska, Iwona Farelo, Liliana Pimenta, João Seixas, Fernando A. Ferreira, Mafalda S. Marques, João P. Miranda, Inês Letty, Jérôme Jenny, Hannes Hackländer, Klaus Magnussen, Eyðfinn Melo-Ferreira, José Introgression drives repeated evolution of winter coat color polymorphism in hares |
topic_facet |
Biological Sciences |
description |
Changing from summer-brown to winter-white pelage or plumage is a crucial adaptation to seasonal snow in more than 20 mammal and bird species. Many of these species maintain nonwhite winter morphs, locally adapted to less snowy conditions, which may have evolved independently. Mountain hares (Lepus timidus) from Fennoscandia were introduced into the Faroe Islands in 1855. While they were initially winter-white, within ∼65 y all Faroese hares became winter-gray, a morph that occurs in the source population at low frequency. The documented population history makes this a valuable model for understanding the genetic basis and evolution of the seasonal trait polymorphism. Through whole-genome scans of differentiation and single-nucleotide polymorphism (SNP) genotyping, we associated winter coat color polymorphism to the genomic region of the pigmentation gene Agouti, previously linked to introgression-driven winter coat color variation in the snowshoe hare (Lepus americanus). Lower Agouti expression in the skin of winter-gray individuals during the autumn molt suggests that regulatory changes may underlie the color polymorphism. Variation in the associated genomic region shows signatures of a selective sweep in the Faroese population, suggesting that positive selection drove the fixation of the variant after the introduction. Whole-genome analyses of several hare species revealed that the winter-gray variant originated through introgression from a noncolor changing species, in keeping with the history of ancient hybridization between the species. Our findings show the recurrent role of introgression in generating winter coat color variation by repeatedly recruiting the regulatory region of Agouti to modulate seasonal coat color change. |
format |
Text |
author |
Giska, Iwona Farelo, Liliana Pimenta, João Seixas, Fernando A. Ferreira, Mafalda S. Marques, João P. Miranda, Inês Letty, Jérôme Jenny, Hannes Hackländer, Klaus Magnussen, Eyðfinn Melo-Ferreira, José |
author_facet |
Giska, Iwona Farelo, Liliana Pimenta, João Seixas, Fernando A. Ferreira, Mafalda S. Marques, João P. Miranda, Inês Letty, Jérôme Jenny, Hannes Hackländer, Klaus Magnussen, Eyðfinn Melo-Ferreira, José |
author_sort |
Giska, Iwona |
title |
Introgression drives repeated evolution of winter coat color polymorphism in hares |
title_short |
Introgression drives repeated evolution of winter coat color polymorphism in hares |
title_full |
Introgression drives repeated evolution of winter coat color polymorphism in hares |
title_fullStr |
Introgression drives repeated evolution of winter coat color polymorphism in hares |
title_full_unstemmed |
Introgression drives repeated evolution of winter coat color polymorphism in hares |
title_sort |
introgression drives repeated evolution of winter coat color polymorphism in hares |
publisher |
National Academy of Sciences |
publishDate |
2019 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883779/ http://www.ncbi.nlm.nih.gov/pubmed/31712446 https://doi.org/10.1073/pnas.1910471116 |
geographic |
Faroe Islands |
geographic_facet |
Faroe Islands |
genre |
Faroe Islands Fennoscandia Lepus timidus |
genre_facet |
Faroe Islands Fennoscandia Lepus timidus |
op_source |
Proc Natl Acad Sci U S A |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883779/ http://www.ncbi.nlm.nih.gov/pubmed/31712446 http://dx.doi.org/10.1073/pnas.1910471116 |
op_rights |
https://www.pnas.org/site/aboutpnas/licenses.xhtmlPublished under the PNAS license (https://www.pnas.org/site/aboutpnas/licenses.xhtml) . |
op_doi |
https://doi.org/10.1073/pnas.1910471116 |
container_title |
Proceedings of the National Academy of Sciences |
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116 |
container_issue |
48 |
container_start_page |
24150 |
op_container_end_page |
24156 |
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1765996090947010560 |