High Prevalence of Dystonia in the Faroe Islands: A Population-Based Study
BACKGROUND: There are fewer than five population-based studies of dystonia worldwide. Only one utilized a movement disorders neurologist. Given the potential for founder effects, and the highly genetic nature of dystonia, the Faroe Islands provide a particularly interesting setting to study the prev...
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ftpubmed:oai:pubmedcentral.nih.gov:6881520 2023-05-15T16:10:38+02:00 High Prevalence of Dystonia in the Faroe Islands: A Population-Based Study Louis, Elan D. Eliasen, Eina H. Kim, Christine Y. Ferrer, Monica Gaini, Shahin Petersen, Maria Skaalum 2019-08-20 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6881520/ http://www.ncbi.nlm.nih.gov/pubmed/31430749 https://doi.org/10.1159/000502455 en eng http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6881520/ http://www.ncbi.nlm.nih.gov/pubmed/31430749 http://dx.doi.org/10.1159/000502455 Neuroepidemiology Article Text 2019 ftpubmed https://doi.org/10.1159/000502455 2020-08-23T00:15:40Z BACKGROUND: There are fewer than five population-based studies of dystonia worldwide. Only one utilized a movement disorders neurologist. Given the potential for founder effects, and the highly genetic nature of dystonia, the Faroe Islands provide a particularly interesting setting to study the prevalence of dystonia. OBJECTIVE: To estimate the prevalence of dystonia. METHODS: We used a two-phase, population-based design, screening 1,334 randomly-selected Faroese individuals aged ≥40 years from which a subsample of 227 participated in an in-person clinical evaluation. Dystonia was assessed by two movement disorder neurologists using videotaped examinations. RESULTS: Two of 227 (0.88%, 95% confidence interval [CI] −0.33% – 2.09%) were diagnosed with cervical or segmental dystonia. An unusual form of thumb flexion dystonia was noted in 75 more, yielding a combined prevalence of 33.92% (95% CI 27.73% – 40.11%). CONCLUSIONS: The prevalence of cervical or segmental dystonia was as high as in one prior population population-based study using similar methods. Furthermore, an unusual form of thumb flexion dystonia was uncovered, which yielded an extraordinarily high prevalence of dystonia in this population. Although our methods likely contributed to more complete capture of subtle dystonia, founder effects are highly likely to have been an additional major contributor to these findings. Text Faroe Islands PubMed Central (PMC) Faroe Islands Thumb ENVELOPE(-64.259,-64.259,-65.247,-65.247) Neuroepidemiology 53 3-4 220 224 |
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Article Louis, Elan D. Eliasen, Eina H. Kim, Christine Y. Ferrer, Monica Gaini, Shahin Petersen, Maria Skaalum High Prevalence of Dystonia in the Faroe Islands: A Population-Based Study |
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BACKGROUND: There are fewer than five population-based studies of dystonia worldwide. Only one utilized a movement disorders neurologist. Given the potential for founder effects, and the highly genetic nature of dystonia, the Faroe Islands provide a particularly interesting setting to study the prevalence of dystonia. OBJECTIVE: To estimate the prevalence of dystonia. METHODS: We used a two-phase, population-based design, screening 1,334 randomly-selected Faroese individuals aged ≥40 years from which a subsample of 227 participated in an in-person clinical evaluation. Dystonia was assessed by two movement disorder neurologists using videotaped examinations. RESULTS: Two of 227 (0.88%, 95% confidence interval [CI] −0.33% – 2.09%) were diagnosed with cervical or segmental dystonia. An unusual form of thumb flexion dystonia was noted in 75 more, yielding a combined prevalence of 33.92% (95% CI 27.73% – 40.11%). CONCLUSIONS: The prevalence of cervical or segmental dystonia was as high as in one prior population population-based study using similar methods. Furthermore, an unusual form of thumb flexion dystonia was uncovered, which yielded an extraordinarily high prevalence of dystonia in this population. Although our methods likely contributed to more complete capture of subtle dystonia, founder effects are highly likely to have been an additional major contributor to these findings. |
format |
Text |
author |
Louis, Elan D. Eliasen, Eina H. Kim, Christine Y. Ferrer, Monica Gaini, Shahin Petersen, Maria Skaalum |
author_facet |
Louis, Elan D. Eliasen, Eina H. Kim, Christine Y. Ferrer, Monica Gaini, Shahin Petersen, Maria Skaalum |
author_sort |
Louis, Elan D. |
title |
High Prevalence of Dystonia in the Faroe Islands: A Population-Based Study |
title_short |
High Prevalence of Dystonia in the Faroe Islands: A Population-Based Study |
title_full |
High Prevalence of Dystonia in the Faroe Islands: A Population-Based Study |
title_fullStr |
High Prevalence of Dystonia in the Faroe Islands: A Population-Based Study |
title_full_unstemmed |
High Prevalence of Dystonia in the Faroe Islands: A Population-Based Study |
title_sort |
high prevalence of dystonia in the faroe islands: a population-based study |
publishDate |
2019 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6881520/ http://www.ncbi.nlm.nih.gov/pubmed/31430749 https://doi.org/10.1159/000502455 |
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ENVELOPE(-64.259,-64.259,-65.247,-65.247) |
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Faroe Islands Thumb |
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Faroe Islands Thumb |
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Faroe Islands |
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Faroe Islands |
op_source |
Neuroepidemiology |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6881520/ http://www.ncbi.nlm.nih.gov/pubmed/31430749 http://dx.doi.org/10.1159/000502455 |
op_doi |
https://doi.org/10.1159/000502455 |
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Neuroepidemiology |
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53 |
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3-4 |
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220 |
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224 |
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