Bioorganic synthesis, characterization and evaluation of a natural phenolic lipid
The first synthesis of a phenolic natural monoacylglycerol (1- [11-(ferulyloxy) undecanoyl)] glycerol) was carried out by bioorganic synthesis starting from ferulic acid. The synthetic route of the target lipidic compound was designed involving a chemo-enzymatic approach using immobilized Candida an...
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ftpubmed:oai:pubmedcentral.nih.gov:6796520 2023-05-15T13:36:41+02:00 Bioorganic synthesis, characterization and evaluation of a natural phenolic lipid Johny, Juliya Kontham, Venkateshwarlu Veeragoni, Dileep Misra, Sunil Kaki, Shiva Shanker 2019-09-12 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6796520/ http://www.ncbi.nlm.nih.gov/pubmed/31641619 https://doi.org/10.1016/j.btre.2019.e00375 en eng Elsevier http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6796520/ http://www.ncbi.nlm.nih.gov/pubmed/31641619 http://dx.doi.org/10.1016/j.btre.2019.e00375 © 2019 The Authors. Published by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). CC-BY-NC-ND Article Text 2019 ftpubmed https://doi.org/10.1016/j.btre.2019.e00375 2019-10-27T00:26:21Z The first synthesis of a phenolic natural monoacylglycerol (1- [11-(ferulyloxy) undecanoyl)] glycerol) was carried out by bioorganic synthesis starting from ferulic acid. The synthetic route of the target lipidic compound was designed involving a chemo-enzymatic approach using immobilized Candida antarctica lipase as biocatalyst in two of the steps conducted in organic medium. The prepared lipidic compound was characterized by using spectral data and evaluated for antimicrobial, antioxidant and cytotoxic studies to examine its potential. The synthesized compound showed moderate antimicrobial activity and showed very good antioxidant activity in DPPH radical scavenging assay and also in oxidation inhibition in soybean oil by differential scanning calorimetry. The cytotoxic studies of the synthetic lipid showed promising activity against A549 and HeLa cancer cell lines with IC(50) values of 9.102 and 9.886 μM respectively. The prepared compound can be useful in designing novel phenolic lipids with potential applications in cosmetic and biomedical fields. Text Antarc* Antarctica PubMed Central (PMC) Biotechnology Reports 24 e00375 |
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Article Johny, Juliya Kontham, Venkateshwarlu Veeragoni, Dileep Misra, Sunil Kaki, Shiva Shanker Bioorganic synthesis, characterization and evaluation of a natural phenolic lipid |
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Article |
description |
The first synthesis of a phenolic natural monoacylglycerol (1- [11-(ferulyloxy) undecanoyl)] glycerol) was carried out by bioorganic synthesis starting from ferulic acid. The synthetic route of the target lipidic compound was designed involving a chemo-enzymatic approach using immobilized Candida antarctica lipase as biocatalyst in two of the steps conducted in organic medium. The prepared lipidic compound was characterized by using spectral data and evaluated for antimicrobial, antioxidant and cytotoxic studies to examine its potential. The synthesized compound showed moderate antimicrobial activity and showed very good antioxidant activity in DPPH radical scavenging assay and also in oxidation inhibition in soybean oil by differential scanning calorimetry. The cytotoxic studies of the synthetic lipid showed promising activity against A549 and HeLa cancer cell lines with IC(50) values of 9.102 and 9.886 μM respectively. The prepared compound can be useful in designing novel phenolic lipids with potential applications in cosmetic and biomedical fields. |
format |
Text |
author |
Johny, Juliya Kontham, Venkateshwarlu Veeragoni, Dileep Misra, Sunil Kaki, Shiva Shanker |
author_facet |
Johny, Juliya Kontham, Venkateshwarlu Veeragoni, Dileep Misra, Sunil Kaki, Shiva Shanker |
author_sort |
Johny, Juliya |
title |
Bioorganic synthesis, characterization and evaluation of a natural phenolic lipid |
title_short |
Bioorganic synthesis, characterization and evaluation of a natural phenolic lipid |
title_full |
Bioorganic synthesis, characterization and evaluation of a natural phenolic lipid |
title_fullStr |
Bioorganic synthesis, characterization and evaluation of a natural phenolic lipid |
title_full_unstemmed |
Bioorganic synthesis, characterization and evaluation of a natural phenolic lipid |
title_sort |
bioorganic synthesis, characterization and evaluation of a natural phenolic lipid |
publisher |
Elsevier |
publishDate |
2019 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6796520/ http://www.ncbi.nlm.nih.gov/pubmed/31641619 https://doi.org/10.1016/j.btre.2019.e00375 |
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Antarc* Antarctica |
genre_facet |
Antarc* Antarctica |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6796520/ http://www.ncbi.nlm.nih.gov/pubmed/31641619 http://dx.doi.org/10.1016/j.btre.2019.e00375 |
op_rights |
© 2019 The Authors. Published by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
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CC-BY-NC-ND |
op_doi |
https://doi.org/10.1016/j.btre.2019.e00375 |
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Biotechnology Reports |
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24 |
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e00375 |
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1766082328245829632 |