Dynamic Restructuring of a Rhythmic Motor Program by a Single Mechanoreceptor Neuron in Lobster
We have explored the synaptic and cellular mechanisms by which a single primary mechanosensory neuron, the anterior gastric receptor (AGR), reconfigures motor output of the gastric mill central pattern generator (CPG) in the stomatogastric nervous system (STNS) of the lobster Homarus gammarus. AGR i...
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ftpubmed:oai:pubmedcentral.nih.gov:6782242 2023-05-15T16:34:44+02:00 Dynamic Restructuring of a Rhythmic Motor Program by a Single Mechanoreceptor Neuron in Lobster Combes, Denis Meyrand, Pierre Simmers, John 1999-05-01 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6782242/ http://www.ncbi.nlm.nih.gov/pubmed/10212320 https://doi.org/10.1523/JNEUROSCI.19-09-03620.1999 en eng Society for Neuroscience http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6782242/ http://www.ncbi.nlm.nih.gov/pubmed/10212320 http://dx.doi.org/10.1523/JNEUROSCI.19-09-03620.1999 Copyright © 1999 Society for Neuroscience Article Text 1999 ftpubmed https://doi.org/10.1523/JNEUROSCI.19-09-03620.1999 2019-10-27T00:16:07Z We have explored the synaptic and cellular mechanisms by which a single primary mechanosensory neuron, the anterior gastric receptor (AGR), reconfigures motor output of the gastric mill central pattern generator (CPG) in the stomatogastric nervous system (STNS) of the lobster Homarus gammarus. AGR is activated in vivo by contraction of the medial tooth protractor muscle gm1 and accesses the gastric CPG via excitation of two in-parallel interneurons, the excitatory commissural gastric (CG) and the inhibitory gastric inhibitor (GI). In the spontaneously active STNSin vitro, weak firing of AGR in time with gastric mill motoneurons (GM) reinforces an ongoing type I gastric mill rhythm in which all gastric teeth power-stroke motoneurons are synchronously active. With strong AGR firing, these phase relationships switch abruptly to a type II pattern in which lateral and medial teeth power-stroke motoneurons fire in antiphase. Our results suggest that these bimodal actions on the gastric mill rhythm depend on the balance of firing of the CG and GI interneurons and that selection of the pathway resides in their different postsynaptic sensitivities to AGR. Whereas high intrinsic firing rates of the CG neuron ensure that the excitatory pathway predominates during low levels of sensory input, strong synaptic facilitation in the GI neuron favors the inhibitory pathway during high levels of receptor activity. Feedback from a single mechanosensory neuron is thus able, in an activity-dependent manner, to specify different motor programs from a single central pattern-generating network. Text Homarus gammarus PubMed Central (PMC) The Journal of Neuroscience 19 9 3620 3628 |
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Article Combes, Denis Meyrand, Pierre Simmers, John Dynamic Restructuring of a Rhythmic Motor Program by a Single Mechanoreceptor Neuron in Lobster |
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Article |
description |
We have explored the synaptic and cellular mechanisms by which a single primary mechanosensory neuron, the anterior gastric receptor (AGR), reconfigures motor output of the gastric mill central pattern generator (CPG) in the stomatogastric nervous system (STNS) of the lobster Homarus gammarus. AGR is activated in vivo by contraction of the medial tooth protractor muscle gm1 and accesses the gastric CPG via excitation of two in-parallel interneurons, the excitatory commissural gastric (CG) and the inhibitory gastric inhibitor (GI). In the spontaneously active STNSin vitro, weak firing of AGR in time with gastric mill motoneurons (GM) reinforces an ongoing type I gastric mill rhythm in which all gastric teeth power-stroke motoneurons are synchronously active. With strong AGR firing, these phase relationships switch abruptly to a type II pattern in which lateral and medial teeth power-stroke motoneurons fire in antiphase. Our results suggest that these bimodal actions on the gastric mill rhythm depend on the balance of firing of the CG and GI interneurons and that selection of the pathway resides in their different postsynaptic sensitivities to AGR. Whereas high intrinsic firing rates of the CG neuron ensure that the excitatory pathway predominates during low levels of sensory input, strong synaptic facilitation in the GI neuron favors the inhibitory pathway during high levels of receptor activity. Feedback from a single mechanosensory neuron is thus able, in an activity-dependent manner, to specify different motor programs from a single central pattern-generating network. |
format |
Text |
author |
Combes, Denis Meyrand, Pierre Simmers, John |
author_facet |
Combes, Denis Meyrand, Pierre Simmers, John |
author_sort |
Combes, Denis |
title |
Dynamic Restructuring of a Rhythmic Motor Program by a Single Mechanoreceptor Neuron in Lobster |
title_short |
Dynamic Restructuring of a Rhythmic Motor Program by a Single Mechanoreceptor Neuron in Lobster |
title_full |
Dynamic Restructuring of a Rhythmic Motor Program by a Single Mechanoreceptor Neuron in Lobster |
title_fullStr |
Dynamic Restructuring of a Rhythmic Motor Program by a Single Mechanoreceptor Neuron in Lobster |
title_full_unstemmed |
Dynamic Restructuring of a Rhythmic Motor Program by a Single Mechanoreceptor Neuron in Lobster |
title_sort |
dynamic restructuring of a rhythmic motor program by a single mechanoreceptor neuron in lobster |
publisher |
Society for Neuroscience |
publishDate |
1999 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6782242/ http://www.ncbi.nlm.nih.gov/pubmed/10212320 https://doi.org/10.1523/JNEUROSCI.19-09-03620.1999 |
genre |
Homarus gammarus |
genre_facet |
Homarus gammarus |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6782242/ http://www.ncbi.nlm.nih.gov/pubmed/10212320 http://dx.doi.org/10.1523/JNEUROSCI.19-09-03620.1999 |
op_rights |
Copyright © 1999 Society for Neuroscience |
op_doi |
https://doi.org/10.1523/JNEUROSCI.19-09-03620.1999 |
container_title |
The Journal of Neuroscience |
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19 |
container_issue |
9 |
container_start_page |
3620 |
op_container_end_page |
3628 |
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1766024707069444096 |