Increase in tympanostomy tube placements despite pneumococcal vaccination, a population‐based study
AIM: The aim was to estimate the impact of the 10‐valent pneumococcal vaccine (PHiD‐CV) on tympanostomy tube placements (TTP) in children under five years of age in Iceland. METHODS: This population‐based observational cohort study followed 11 consecutive birth‐cohorts 2005–2015 from birth until the...
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ftpubmed:oai:pubmedcentral.nih.gov:6767502 2023-05-15T16:47:58+02:00 Increase in tympanostomy tube placements despite pneumococcal vaccination, a population‐based study Eythorsson, Elias Sigurdsson, Samuel Erlendsdóttir, Helga Hrafnkelsson, Birgir Kristinsson, Karl G. Haraldsson, Ásgeir 2019-02-17 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767502/ http://www.ncbi.nlm.nih.gov/pubmed/30667099 https://doi.org/10.1111/apa.14724 en eng John Wiley and Sons Inc. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767502/ http://www.ncbi.nlm.nih.gov/pubmed/30667099 http://dx.doi.org/10.1111/apa.14724 ©2019 The Authors. Acta Pædiatrica published by John Wiley & Sons Ltd on behalf of Foundation Acta Pædiatrica This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. CC-BY-NC Regular Articles Text 2019 ftpubmed https://doi.org/10.1111/apa.14724 2019-10-06T00:45:19Z AIM: The aim was to estimate the impact of the 10‐valent pneumococcal vaccine (PHiD‐CV) on tympanostomy tube placements (TTP) in children under five years of age in Iceland. METHODS: This population‐based observational cohort study followed 11 consecutive birth‐cohorts 2005–2015 from birth until their fifth birthday. Population registries were merged using national identification numbers. The risk of TTP was compared between birth‐cohorts adjusted for the number of previous otitis media diagnoses and antimicrobial prescriptions. A Cox regression model was applied and the hazard ratio (HR) of TTP was estimated between each birth‐cohort and the last vaccine non‐eligible birth‐cohort. The vaccine impact of PHiD‐CV10 on TTP was estimated as 1‐HR ×100%. RESULTS: In total, 51 247 children were followed for 210 724 person‐years, of which 14 351 underwent 20 373 procedures. The estimated vaccine impact on TTP was −6% (95% CI −16% to 2.7%). Children in the vaccine‐eligible cohorts had fewer previous otitis media diagnoses and had been prescribed fewer antimicrobials prior to the procedure than children in the vaccine non‐eligible cohorts. CONCLUSION: Despite high uptake of PHiD‐CV10, tympanostomy procedures increased in Iceland during the study period. Vaccine‐eligible children had milder disease prior to the procedure. The reason underlying these findings are speculative. Text Iceland PubMed Central (PMC) Acta Paediatrica 108 8 1527 1534 |
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Regular Articles Eythorsson, Elias Sigurdsson, Samuel Erlendsdóttir, Helga Hrafnkelsson, Birgir Kristinsson, Karl G. Haraldsson, Ásgeir Increase in tympanostomy tube placements despite pneumococcal vaccination, a population‐based study |
topic_facet |
Regular Articles |
description |
AIM: The aim was to estimate the impact of the 10‐valent pneumococcal vaccine (PHiD‐CV) on tympanostomy tube placements (TTP) in children under five years of age in Iceland. METHODS: This population‐based observational cohort study followed 11 consecutive birth‐cohorts 2005–2015 from birth until their fifth birthday. Population registries were merged using national identification numbers. The risk of TTP was compared between birth‐cohorts adjusted for the number of previous otitis media diagnoses and antimicrobial prescriptions. A Cox regression model was applied and the hazard ratio (HR) of TTP was estimated between each birth‐cohort and the last vaccine non‐eligible birth‐cohort. The vaccine impact of PHiD‐CV10 on TTP was estimated as 1‐HR ×100%. RESULTS: In total, 51 247 children were followed for 210 724 person‐years, of which 14 351 underwent 20 373 procedures. The estimated vaccine impact on TTP was −6% (95% CI −16% to 2.7%). Children in the vaccine‐eligible cohorts had fewer previous otitis media diagnoses and had been prescribed fewer antimicrobials prior to the procedure than children in the vaccine non‐eligible cohorts. CONCLUSION: Despite high uptake of PHiD‐CV10, tympanostomy procedures increased in Iceland during the study period. Vaccine‐eligible children had milder disease prior to the procedure. The reason underlying these findings are speculative. |
format |
Text |
author |
Eythorsson, Elias Sigurdsson, Samuel Erlendsdóttir, Helga Hrafnkelsson, Birgir Kristinsson, Karl G. Haraldsson, Ásgeir |
author_facet |
Eythorsson, Elias Sigurdsson, Samuel Erlendsdóttir, Helga Hrafnkelsson, Birgir Kristinsson, Karl G. Haraldsson, Ásgeir |
author_sort |
Eythorsson, Elias |
title |
Increase in tympanostomy tube placements despite pneumococcal vaccination, a population‐based study |
title_short |
Increase in tympanostomy tube placements despite pneumococcal vaccination, a population‐based study |
title_full |
Increase in tympanostomy tube placements despite pneumococcal vaccination, a population‐based study |
title_fullStr |
Increase in tympanostomy tube placements despite pneumococcal vaccination, a population‐based study |
title_full_unstemmed |
Increase in tympanostomy tube placements despite pneumococcal vaccination, a population‐based study |
title_sort |
increase in tympanostomy tube placements despite pneumococcal vaccination, a population‐based study |
publisher |
John Wiley and Sons Inc. |
publishDate |
2019 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767502/ http://www.ncbi.nlm.nih.gov/pubmed/30667099 https://doi.org/10.1111/apa.14724 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767502/ http://www.ncbi.nlm.nih.gov/pubmed/30667099 http://dx.doi.org/10.1111/apa.14724 |
op_rights |
©2019 The Authors. Acta Pædiatrica published by John Wiley & Sons Ltd on behalf of Foundation Acta Pædiatrica This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
op_rightsnorm |
CC-BY-NC |
op_doi |
https://doi.org/10.1111/apa.14724 |
container_title |
Acta Paediatrica |
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108 |
container_issue |
8 |
container_start_page |
1527 |
op_container_end_page |
1534 |
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1766038071214604288 |