Heritability and complex segregation analysis of diabetes mellitus in American Eskimo Dogs
BACKGROUND: Heritability and mode of inheritance of spontaneous diabetes mellitus (DM) in American Eskimo Dogs (AED) are unknown. OBJECTIVE: Investigate the heritability and mode of inheritance of DM in AED. ANIMALS: An extended family of AED including 71 AED without DM, 47 AED with an unknown pheno...
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ftpubmed:oai:pubmedcentral.nih.gov:6766479 2023-05-15T16:06:57+02:00 Heritability and complex segregation analysis of diabetes mellitus in American Eskimo Dogs Cai, Stephen V. Famula, Thomas R. Oberbauer, Anita M. Hess, Rebecka S. 2019-07-18 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6766479/ http://www.ncbi.nlm.nih.gov/pubmed/31318104 https://doi.org/10.1111/jvim.15570 en eng John Wiley & Sons, Inc. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6766479/ http://www.ncbi.nlm.nih.gov/pubmed/31318104 http://dx.doi.org/10.1111/jvim.15570 © 2019 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. CC-BY-NC SMALL ANIMAL Text 2019 ftpubmed https://doi.org/10.1111/jvim.15570 2019-10-06T00:42:56Z BACKGROUND: Heritability and mode of inheritance of spontaneous diabetes mellitus (DM) in American Eskimo Dogs (AED) are unknown. OBJECTIVE: Investigate the heritability and mode of inheritance of DM in AED. ANIMALS: An extended family of AED including 71 AED without DM, 47 AED with an unknown phenotype, and 38 AED with spontaneous DM. METHODS: Retrospective evaluation of inheritance. A logistic regression model was formulated to evaluate the heritability of DM, including effects of sex and neuter status. Subsequently, complex segregation analysis was employed to investigate the inheritance pattern of DM in AED. Six plausible models were considered, and the Akaike Information Criterion was used to determine the best of the biologically feasible models of inheritance of DM in AED. RESULTS: Heritability of DM in AED is estimated at 0.62 (95% posterior interval 0.01‐0.99). Predicted DM probabilities for neutered females (NF), intact females (IF), neutered males (NM), and intact males (IM) were 0.76, 0.11, 0.63, and 0.12, respectively. There was no overlap between the 95% posterior intervals of disease probabilities in NF and IF or in NF and IM. Complex segregation analysis suggested that the mode of inheritance of DM in AED is polygenic, with no evidence for a single gene of large effect. CONCLUSIONS AND CLINICAL IMPORTANCE: The estimated heritability of DM in AED is high but has low precision. Diabetes mellitus transmission in AED appears to follow a polygenic inheritance. Breeders could successfully implement a breeding program to decrease the incidence of DM in AED. Text eskimo* PubMed Central (PMC) Journal of Veterinary Internal Medicine 33 5 1926 1934 |
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SMALL ANIMAL Cai, Stephen V. Famula, Thomas R. Oberbauer, Anita M. Hess, Rebecka S. Heritability and complex segregation analysis of diabetes mellitus in American Eskimo Dogs |
topic_facet |
SMALL ANIMAL |
description |
BACKGROUND: Heritability and mode of inheritance of spontaneous diabetes mellitus (DM) in American Eskimo Dogs (AED) are unknown. OBJECTIVE: Investigate the heritability and mode of inheritance of DM in AED. ANIMALS: An extended family of AED including 71 AED without DM, 47 AED with an unknown phenotype, and 38 AED with spontaneous DM. METHODS: Retrospective evaluation of inheritance. A logistic regression model was formulated to evaluate the heritability of DM, including effects of sex and neuter status. Subsequently, complex segregation analysis was employed to investigate the inheritance pattern of DM in AED. Six plausible models were considered, and the Akaike Information Criterion was used to determine the best of the biologically feasible models of inheritance of DM in AED. RESULTS: Heritability of DM in AED is estimated at 0.62 (95% posterior interval 0.01‐0.99). Predicted DM probabilities for neutered females (NF), intact females (IF), neutered males (NM), and intact males (IM) were 0.76, 0.11, 0.63, and 0.12, respectively. There was no overlap between the 95% posterior intervals of disease probabilities in NF and IF or in NF and IM. Complex segregation analysis suggested that the mode of inheritance of DM in AED is polygenic, with no evidence for a single gene of large effect. CONCLUSIONS AND CLINICAL IMPORTANCE: The estimated heritability of DM in AED is high but has low precision. Diabetes mellitus transmission in AED appears to follow a polygenic inheritance. Breeders could successfully implement a breeding program to decrease the incidence of DM in AED. |
format |
Text |
author |
Cai, Stephen V. Famula, Thomas R. Oberbauer, Anita M. Hess, Rebecka S. |
author_facet |
Cai, Stephen V. Famula, Thomas R. Oberbauer, Anita M. Hess, Rebecka S. |
author_sort |
Cai, Stephen V. |
title |
Heritability and complex segregation analysis of diabetes mellitus in American Eskimo Dogs |
title_short |
Heritability and complex segregation analysis of diabetes mellitus in American Eskimo Dogs |
title_full |
Heritability and complex segregation analysis of diabetes mellitus in American Eskimo Dogs |
title_fullStr |
Heritability and complex segregation analysis of diabetes mellitus in American Eskimo Dogs |
title_full_unstemmed |
Heritability and complex segregation analysis of diabetes mellitus in American Eskimo Dogs |
title_sort |
heritability and complex segregation analysis of diabetes mellitus in american eskimo dogs |
publisher |
John Wiley & Sons, Inc. |
publishDate |
2019 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6766479/ http://www.ncbi.nlm.nih.gov/pubmed/31318104 https://doi.org/10.1111/jvim.15570 |
genre |
eskimo* |
genre_facet |
eskimo* |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6766479/ http://www.ncbi.nlm.nih.gov/pubmed/31318104 http://dx.doi.org/10.1111/jvim.15570 |
op_rights |
© 2019 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
op_rightsnorm |
CC-BY-NC |
op_doi |
https://doi.org/10.1111/jvim.15570 |
container_title |
Journal of Veterinary Internal Medicine |
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33 |
container_issue |
5 |
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1926 |
op_container_end_page |
1934 |
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1766402957654360064 |