Association between early lead exposure and externalizing behaviors in adolescence: a developmental cascade
BACKGROUND: Lead (Pb) exposure is associated with adverse neurological development. Most notably, it has been observed through externalizing behavior symptoms, as observed among Inuit children from northern Québec. Evidence for a persistent neurological impact of early Pb exposure later in life is h...
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ftpubmed:oai:pubmedcentral.nih.gov:6759380 2023-05-15T16:55:05+02:00 Association between early lead exposure and externalizing behaviors in adolescence: a developmental cascade Desrochers-Couture, Mireille Courtemanche, Yohann Forget-Dubois, Nadine Bélanger, Richard E. Boucher, Olivier Ayotte, Pierre Cordier, Sylvaine Jacobson, Joseph L. Jacobson, Sandra W. Muckle, Gina 2019-08-19 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6759380/ http://www.ncbi.nlm.nih.gov/pubmed/31454729 https://doi.org/10.1016/j.envres.2019.108679 en eng http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6759380/ http://www.ncbi.nlm.nih.gov/pubmed/31454729 http://dx.doi.org/10.1016/j.envres.2019.108679 Environ Res Article Text 2019 ftpubmed https://doi.org/10.1016/j.envres.2019.108679 2020-11-08T01:17:26Z BACKGROUND: Lead (Pb) exposure is associated with adverse neurological development. Most notably, it has been observed through externalizing behavior symptoms, as observed among Inuit children from northern Québec. Evidence for a persistent neurological impact of early Pb exposure later in life is however scarce. Pb exposure may initiate a developmental cascade that increases the risk of long-term behavior problems. OBJECTIVES: Testing for direct associations between childhood Pb concentrations and adolescent externalizing symptoms and substance use, as well as indirect associations through childhood behavior assessments. METHODS: The study sample is a longitudinal cohort of Inuit children (n=212) followed since birth. Blood Pb concentrations were measured during childhood (median age = 11.4 years) and adolescence (median age=18.5 years). Externalizing/inattentive behavior were teacher-assessed through the Teacher Report Form and the Disruptive Behavior Disorders Rating Scale for children. At the adolescence follow-up, behavior problems were self-reported by filling Achenbach’s Youth Self-Report, the Barkley Adult ADHD-IV Rating Scale, and the Diagnostics Interview Schedule for Children. Adolescent substance use was also self-assessed through the DEP-ADO. Direct and indirect associations of child Pb concentrations with adolescent outcomes were tested through mediation models. RESULTS: Child blood Pb concentrations were not directly associated with any adolescent outcomes. On the contrary, childhood Pb exposure was indirectly associated, through childhood externalizing behavior assessments, with adolescent externalizing behaviors, binge drinking, and cannabis use. These indirect associations held after controlling for adolescents’ concurrent Pb blood concentrations. DISCUSSION: Our results highlight the indirect but lasting effects of child Pb exposure on adolescent behavior problems, and the importance of childhood externalizing behavior in this relationship. Adverse early-life environment put children on a ... Text inuit PubMed Central (PMC) Environmental Research 178 108679 |
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Article Desrochers-Couture, Mireille Courtemanche, Yohann Forget-Dubois, Nadine Bélanger, Richard E. Boucher, Olivier Ayotte, Pierre Cordier, Sylvaine Jacobson, Joseph L. Jacobson, Sandra W. Muckle, Gina Association between early lead exposure and externalizing behaviors in adolescence: a developmental cascade |
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BACKGROUND: Lead (Pb) exposure is associated with adverse neurological development. Most notably, it has been observed through externalizing behavior symptoms, as observed among Inuit children from northern Québec. Evidence for a persistent neurological impact of early Pb exposure later in life is however scarce. Pb exposure may initiate a developmental cascade that increases the risk of long-term behavior problems. OBJECTIVES: Testing for direct associations between childhood Pb concentrations and adolescent externalizing symptoms and substance use, as well as indirect associations through childhood behavior assessments. METHODS: The study sample is a longitudinal cohort of Inuit children (n=212) followed since birth. Blood Pb concentrations were measured during childhood (median age = 11.4 years) and adolescence (median age=18.5 years). Externalizing/inattentive behavior were teacher-assessed through the Teacher Report Form and the Disruptive Behavior Disorders Rating Scale for children. At the adolescence follow-up, behavior problems were self-reported by filling Achenbach’s Youth Self-Report, the Barkley Adult ADHD-IV Rating Scale, and the Diagnostics Interview Schedule for Children. Adolescent substance use was also self-assessed through the DEP-ADO. Direct and indirect associations of child Pb concentrations with adolescent outcomes were tested through mediation models. RESULTS: Child blood Pb concentrations were not directly associated with any adolescent outcomes. On the contrary, childhood Pb exposure was indirectly associated, through childhood externalizing behavior assessments, with adolescent externalizing behaviors, binge drinking, and cannabis use. These indirect associations held after controlling for adolescents’ concurrent Pb blood concentrations. DISCUSSION: Our results highlight the indirect but lasting effects of child Pb exposure on adolescent behavior problems, and the importance of childhood externalizing behavior in this relationship. Adverse early-life environment put children on a ... |
format |
Text |
author |
Desrochers-Couture, Mireille Courtemanche, Yohann Forget-Dubois, Nadine Bélanger, Richard E. Boucher, Olivier Ayotte, Pierre Cordier, Sylvaine Jacobson, Joseph L. Jacobson, Sandra W. Muckle, Gina |
author_facet |
Desrochers-Couture, Mireille Courtemanche, Yohann Forget-Dubois, Nadine Bélanger, Richard E. Boucher, Olivier Ayotte, Pierre Cordier, Sylvaine Jacobson, Joseph L. Jacobson, Sandra W. Muckle, Gina |
author_sort |
Desrochers-Couture, Mireille |
title |
Association between early lead exposure and externalizing behaviors in adolescence: a developmental cascade |
title_short |
Association between early lead exposure and externalizing behaviors in adolescence: a developmental cascade |
title_full |
Association between early lead exposure and externalizing behaviors in adolescence: a developmental cascade |
title_fullStr |
Association between early lead exposure and externalizing behaviors in adolescence: a developmental cascade |
title_full_unstemmed |
Association between early lead exposure and externalizing behaviors in adolescence: a developmental cascade |
title_sort |
association between early lead exposure and externalizing behaviors in adolescence: a developmental cascade |
publishDate |
2019 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6759380/ http://www.ncbi.nlm.nih.gov/pubmed/31454729 https://doi.org/10.1016/j.envres.2019.108679 |
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inuit |
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inuit |
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Environ Res |
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6759380/ http://www.ncbi.nlm.nih.gov/pubmed/31454729 http://dx.doi.org/10.1016/j.envres.2019.108679 |
op_doi |
https://doi.org/10.1016/j.envres.2019.108679 |
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Environmental Research |
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178 |
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108679 |
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1766046065285398528 |