Reference intervals for blood-based biochemical analytes of southern Beaufort Sea polar bears
Accurate reference intervals (RIs) for commonly measured blood-based analytes are essential for health monitoring programmes. Baseline values for a panel of analytes can be used to monitor physiologic and pathophysiologic processes such as organ function, electrolyte balance and protein catabolism....
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ftpubmed:oai:pubmedcentral.nih.gov:6748785 2023-05-15T15:10:35+02:00 Reference intervals for blood-based biochemical analytes of southern Beaufort Sea polar bears Fry, Tricia L Friedrichs, Kristen R Atwood, Todd C Duncan, Colleen Simac, Kristin Goldberg, Tony 2019-09-16 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748785/ http://www.ncbi.nlm.nih.gov/pubmed/31548889 https://doi.org/10.1093/conphys/coz040 en eng Oxford University Press http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748785/ http://www.ncbi.nlm.nih.gov/pubmed/31548889 http://dx.doi.org/10.1093/conphys/coz040 © The Author(s) 2019. Published by Oxford University Press and the Society for Experimental Biology. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. CC-BY Research Article Text 2019 ftpubmed https://doi.org/10.1093/conphys/coz040 2019-09-29T00:19:07Z Accurate reference intervals (RIs) for commonly measured blood-based analytes are essential for health monitoring programmes. Baseline values for a panel of analytes can be used to monitor physiologic and pathophysiologic processes such as organ function, electrolyte balance and protein catabolism. Our reference population includes 651 serum samples from polar bears (Ursus maritimus) from the southern Beaufort Sea (SB) subpopulation sampled in Alaska, USA, between 1983 and 2016. To establish RI for 13 biochemical analytes, we defined specific criteria for characterizing the reference population and relevant subgroups. To account for differences in seasonal life history characteristics, we determined separate RI for the spring and fall seasons, when prey availability and energetic requirements of bears differ. We established RI for five subgroups in spring based on sex, age class and denning status, and three subgroups in fall based on sex and age class in females only. Alkaline phosphatase activities were twice as high in subadult as in adult polar bears in spring (z(males) = 4.08, P(males) < 0.001, z(females) = 3.90, P(females) < 0.001) and did not differ between seasons. Denning females had significantly higher glucose concentrations than non-denning females (z = 4.94, P < 0.001), possibly reflecting differences in energy expenditure during lactation. A total of 10 of the 13 analytes differed significantly between seasons in either males or females; however, the physiologic importance of these differences may be minimal. Establishing these RIs allows for temporal monitoring of polar bear health in the SB and may prove useful for assessing and monitoring additional polar bear subpopulations in a changing Arctic environment. Text Arctic Beaufort Sea Ursus maritimus Alaska PubMed Central (PMC) Arctic Conservation Physiology 7 1 |
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English |
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Research Article |
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Research Article Fry, Tricia L Friedrichs, Kristen R Atwood, Todd C Duncan, Colleen Simac, Kristin Goldberg, Tony Reference intervals for blood-based biochemical analytes of southern Beaufort Sea polar bears |
topic_facet |
Research Article |
description |
Accurate reference intervals (RIs) for commonly measured blood-based analytes are essential for health monitoring programmes. Baseline values for a panel of analytes can be used to monitor physiologic and pathophysiologic processes such as organ function, electrolyte balance and protein catabolism. Our reference population includes 651 serum samples from polar bears (Ursus maritimus) from the southern Beaufort Sea (SB) subpopulation sampled in Alaska, USA, between 1983 and 2016. To establish RI for 13 biochemical analytes, we defined specific criteria for characterizing the reference population and relevant subgroups. To account for differences in seasonal life history characteristics, we determined separate RI for the spring and fall seasons, when prey availability and energetic requirements of bears differ. We established RI for five subgroups in spring based on sex, age class and denning status, and three subgroups in fall based on sex and age class in females only. Alkaline phosphatase activities were twice as high in subadult as in adult polar bears in spring (z(males) = 4.08, P(males) < 0.001, z(females) = 3.90, P(females) < 0.001) and did not differ between seasons. Denning females had significantly higher glucose concentrations than non-denning females (z = 4.94, P < 0.001), possibly reflecting differences in energy expenditure during lactation. A total of 10 of the 13 analytes differed significantly between seasons in either males or females; however, the physiologic importance of these differences may be minimal. Establishing these RIs allows for temporal monitoring of polar bear health in the SB and may prove useful for assessing and monitoring additional polar bear subpopulations in a changing Arctic environment. |
format |
Text |
author |
Fry, Tricia L Friedrichs, Kristen R Atwood, Todd C Duncan, Colleen Simac, Kristin Goldberg, Tony |
author_facet |
Fry, Tricia L Friedrichs, Kristen R Atwood, Todd C Duncan, Colleen Simac, Kristin Goldberg, Tony |
author_sort |
Fry, Tricia L |
title |
Reference intervals for blood-based biochemical analytes of southern Beaufort Sea polar bears |
title_short |
Reference intervals for blood-based biochemical analytes of southern Beaufort Sea polar bears |
title_full |
Reference intervals for blood-based biochemical analytes of southern Beaufort Sea polar bears |
title_fullStr |
Reference intervals for blood-based biochemical analytes of southern Beaufort Sea polar bears |
title_full_unstemmed |
Reference intervals for blood-based biochemical analytes of southern Beaufort Sea polar bears |
title_sort |
reference intervals for blood-based biochemical analytes of southern beaufort sea polar bears |
publisher |
Oxford University Press |
publishDate |
2019 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748785/ http://www.ncbi.nlm.nih.gov/pubmed/31548889 https://doi.org/10.1093/conphys/coz040 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic Beaufort Sea Ursus maritimus Alaska |
genre_facet |
Arctic Beaufort Sea Ursus maritimus Alaska |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748785/ http://www.ncbi.nlm.nih.gov/pubmed/31548889 http://dx.doi.org/10.1093/conphys/coz040 |
op_rights |
© The Author(s) 2019. Published by Oxford University Press and the Society for Experimental Biology. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1093/conphys/coz040 |
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Conservation Physiology |
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7 |
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1 |
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