Hibernation induces widespread transcriptional remodeling in metabolic tissues of the grizzly bear
Revealing the mechanisms underlying the reversible physiology of hibernation could have applications to both human and animal health as hibernation is often associated with disease-like states. The present study uses RNA-sequencing to reveal the tissue and seasonal transcriptional changes occurring...
Published in: | Communications Biology |
---|---|
Main Authors: | , , , , , , , , |
Format: | Text |
Language: | English |
Published: |
Nature Publishing Group UK
2019
|
Subjects: | |
Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6744400/ http://www.ncbi.nlm.nih.gov/pubmed/31531397 https://doi.org/10.1038/s42003-019-0574-4 |
id |
ftpubmed:oai:pubmedcentral.nih.gov:6744400 |
---|---|
record_format |
openpolar |
spelling |
ftpubmed:oai:pubmedcentral.nih.gov:6744400 2023-05-15T18:42:01+02:00 Hibernation induces widespread transcriptional remodeling in metabolic tissues of the grizzly bear Jansen, Heiko T. Trojahn, Shawn Saxton, Michael W. Quackenbush, Corey R. Evans Hutzenbiler, Brandon D. Nelson, O. Lynne Cornejo, Omar E. Robbins, Charles T. Kelley, Joanna L. 2019-09-13 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6744400/ http://www.ncbi.nlm.nih.gov/pubmed/31531397 https://doi.org/10.1038/s42003-019-0574-4 en eng Nature Publishing Group UK http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6744400/ http://www.ncbi.nlm.nih.gov/pubmed/31531397 http://dx.doi.org/10.1038/s42003-019-0574-4 © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. CC-BY Article Text 2019 ftpubmed https://doi.org/10.1038/s42003-019-0574-4 2019-09-22T00:28:55Z Revealing the mechanisms underlying the reversible physiology of hibernation could have applications to both human and animal health as hibernation is often associated with disease-like states. The present study uses RNA-sequencing to reveal the tissue and seasonal transcriptional changes occurring in grizzly bears (Ursus arctos horribilis). Comparing hibernation to other seasons, bear adipose has a greater number of differentially expressed genes than liver and skeletal muscle. During hyperphagia, adipose has more than 900 differentially expressed genes compared to active season. Hibernation is characterized by reduced expression of genes associated with insulin signaling, muscle protein degradation, and urea production, and increased expression within muscle protein anabolic pathways. Across all three tissues we find a subset of shared differentially expressed genes, some of which are uncharacterized, that together may reflect a common regulatory mechanism. The identified gene families could be useful for developing novel therapeutics to treat human and animal diseases. Text Ursus arctos PubMed Central (PMC) Communications Biology 2 1 |
institution |
Open Polar |
collection |
PubMed Central (PMC) |
op_collection_id |
ftpubmed |
language |
English |
topic |
Article |
spellingShingle |
Article Jansen, Heiko T. Trojahn, Shawn Saxton, Michael W. Quackenbush, Corey R. Evans Hutzenbiler, Brandon D. Nelson, O. Lynne Cornejo, Omar E. Robbins, Charles T. Kelley, Joanna L. Hibernation induces widespread transcriptional remodeling in metabolic tissues of the grizzly bear |
topic_facet |
Article |
description |
Revealing the mechanisms underlying the reversible physiology of hibernation could have applications to both human and animal health as hibernation is often associated with disease-like states. The present study uses RNA-sequencing to reveal the tissue and seasonal transcriptional changes occurring in grizzly bears (Ursus arctos horribilis). Comparing hibernation to other seasons, bear adipose has a greater number of differentially expressed genes than liver and skeletal muscle. During hyperphagia, adipose has more than 900 differentially expressed genes compared to active season. Hibernation is characterized by reduced expression of genes associated with insulin signaling, muscle protein degradation, and urea production, and increased expression within muscle protein anabolic pathways. Across all three tissues we find a subset of shared differentially expressed genes, some of which are uncharacterized, that together may reflect a common regulatory mechanism. The identified gene families could be useful for developing novel therapeutics to treat human and animal diseases. |
format |
Text |
author |
Jansen, Heiko T. Trojahn, Shawn Saxton, Michael W. Quackenbush, Corey R. Evans Hutzenbiler, Brandon D. Nelson, O. Lynne Cornejo, Omar E. Robbins, Charles T. Kelley, Joanna L. |
author_facet |
Jansen, Heiko T. Trojahn, Shawn Saxton, Michael W. Quackenbush, Corey R. Evans Hutzenbiler, Brandon D. Nelson, O. Lynne Cornejo, Omar E. Robbins, Charles T. Kelley, Joanna L. |
author_sort |
Jansen, Heiko T. |
title |
Hibernation induces widespread transcriptional remodeling in metabolic tissues of the grizzly bear |
title_short |
Hibernation induces widespread transcriptional remodeling in metabolic tissues of the grizzly bear |
title_full |
Hibernation induces widespread transcriptional remodeling in metabolic tissues of the grizzly bear |
title_fullStr |
Hibernation induces widespread transcriptional remodeling in metabolic tissues of the grizzly bear |
title_full_unstemmed |
Hibernation induces widespread transcriptional remodeling in metabolic tissues of the grizzly bear |
title_sort |
hibernation induces widespread transcriptional remodeling in metabolic tissues of the grizzly bear |
publisher |
Nature Publishing Group UK |
publishDate |
2019 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6744400/ http://www.ncbi.nlm.nih.gov/pubmed/31531397 https://doi.org/10.1038/s42003-019-0574-4 |
genre |
Ursus arctos |
genre_facet |
Ursus arctos |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6744400/ http://www.ncbi.nlm.nih.gov/pubmed/31531397 http://dx.doi.org/10.1038/s42003-019-0574-4 |
op_rights |
© The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1038/s42003-019-0574-4 |
container_title |
Communications Biology |
container_volume |
2 |
container_issue |
1 |
_version_ |
1766231620246831104 |