Prevalence and clinical associations of wheezes and crackles in the general population: the Tromsø study
BACKGROUND: Wheezes and crackles are well-known signs of lung diseases, but can also be heard in apparently healthy adults. However, their prevalence in a general population has been sparsely described. The objective of this study was to determine the prevalence of wheezes and crackles in a large ge...
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ftpubmed:oai:pubmedcentral.nih.gov:6739986 2023-05-15T18:34:55+02:00 Prevalence and clinical associations of wheezes and crackles in the general population: the Tromsø study Aviles-Solis, J. C. Jácome, C. Davidsen, A. Einarsen, R. Vanbelle, S. Pasterkamp, H. Melbye, H. 2019-09-11 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739986/ http://www.ncbi.nlm.nih.gov/pubmed/31511003 https://doi.org/10.1186/s12890-019-0928-1 en eng BioMed Central http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739986/ http://www.ncbi.nlm.nih.gov/pubmed/31511003 http://dx.doi.org/10.1186/s12890-019-0928-1 © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. CC0 PDM CC-BY Research Article Text 2019 ftpubmed https://doi.org/10.1186/s12890-019-0928-1 2019-09-22T00:25:37Z BACKGROUND: Wheezes and crackles are well-known signs of lung diseases, but can also be heard in apparently healthy adults. However, their prevalence in a general population has been sparsely described. The objective of this study was to determine the prevalence of wheezes and crackles in a large general adult population and explore associations with self-reported disease, smoking status and lung function. METHODS: We recorded lung sounds in 4033 individuals 40 years or older and collected information on self-reported disease. Pulse oximetry and spirometry were carried out. We estimated age-standardized prevalence of wheezes and crackles and associations between wheezes and crackles and variables of interest were analyzed with univariable and multivariable logistic regressions. RESULTS: Twenty-eight percent of individuals had wheezes or crackles. The age-standardized prevalence of wheezes was 18.6% in women and 15.3% in men, and of crackles, 10.8 and 9.4%, respectively. Wheezes were mostly found during expiration and crackles during inspiration. Significant predictors of expiratory wheezes in multivariable analyses were age (10 years increase - OR 1.18, 95%CI 1.09–1.30), female gender (1.45, 1.2–1.8), self-reported asthma (1.36, 1.00–1.83), and current smoking (1.70, 1.28–2.23). The most important predictors of inspiratory crackles were age (1.76, 1.57–1.99), current smoking, (1.94, 1.40–2.69), mMRC ≥2 (1.79, 1.18–2.65), SpO(2) (0.88, 0.81–0.96), and FEV(1) Z-score (0.86, 0.77–0.95). CONCLUSIONS: Nearly over a quarter of adults present adventitious lung sounds on auscultation. Age was the most important predictor of adventitious sounds, particularly crackles. The adventitious sounds were also associated with self-reported disease, current smoking and measures of lung function. The presence of findings in two or more auscultation sites was associated with a higher risk of decreased lung function than solitary findings. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article ... Text Tromsø PubMed Central (PMC) Tromsø BMC Pulmonary Medicine 19 1 |
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Research Article Aviles-Solis, J. C. Jácome, C. Davidsen, A. Einarsen, R. Vanbelle, S. Pasterkamp, H. Melbye, H. Prevalence and clinical associations of wheezes and crackles in the general population: the Tromsø study |
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Research Article |
description |
BACKGROUND: Wheezes and crackles are well-known signs of lung diseases, but can also be heard in apparently healthy adults. However, their prevalence in a general population has been sparsely described. The objective of this study was to determine the prevalence of wheezes and crackles in a large general adult population and explore associations with self-reported disease, smoking status and lung function. METHODS: We recorded lung sounds in 4033 individuals 40 years or older and collected information on self-reported disease. Pulse oximetry and spirometry were carried out. We estimated age-standardized prevalence of wheezes and crackles and associations between wheezes and crackles and variables of interest were analyzed with univariable and multivariable logistic regressions. RESULTS: Twenty-eight percent of individuals had wheezes or crackles. The age-standardized prevalence of wheezes was 18.6% in women and 15.3% in men, and of crackles, 10.8 and 9.4%, respectively. Wheezes were mostly found during expiration and crackles during inspiration. Significant predictors of expiratory wheezes in multivariable analyses were age (10 years increase - OR 1.18, 95%CI 1.09–1.30), female gender (1.45, 1.2–1.8), self-reported asthma (1.36, 1.00–1.83), and current smoking (1.70, 1.28–2.23). The most important predictors of inspiratory crackles were age (1.76, 1.57–1.99), current smoking, (1.94, 1.40–2.69), mMRC ≥2 (1.79, 1.18–2.65), SpO(2) (0.88, 0.81–0.96), and FEV(1) Z-score (0.86, 0.77–0.95). CONCLUSIONS: Nearly over a quarter of adults present adventitious lung sounds on auscultation. Age was the most important predictor of adventitious sounds, particularly crackles. The adventitious sounds were also associated with self-reported disease, current smoking and measures of lung function. The presence of findings in two or more auscultation sites was associated with a higher risk of decreased lung function than solitary findings. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article ... |
format |
Text |
author |
Aviles-Solis, J. C. Jácome, C. Davidsen, A. Einarsen, R. Vanbelle, S. Pasterkamp, H. Melbye, H. |
author_facet |
Aviles-Solis, J. C. Jácome, C. Davidsen, A. Einarsen, R. Vanbelle, S. Pasterkamp, H. Melbye, H. |
author_sort |
Aviles-Solis, J. C. |
title |
Prevalence and clinical associations of wheezes and crackles in the general population: the Tromsø study |
title_short |
Prevalence and clinical associations of wheezes and crackles in the general population: the Tromsø study |
title_full |
Prevalence and clinical associations of wheezes and crackles in the general population: the Tromsø study |
title_fullStr |
Prevalence and clinical associations of wheezes and crackles in the general population: the Tromsø study |
title_full_unstemmed |
Prevalence and clinical associations of wheezes and crackles in the general population: the Tromsø study |
title_sort |
prevalence and clinical associations of wheezes and crackles in the general population: the tromsø study |
publisher |
BioMed Central |
publishDate |
2019 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739986/ http://www.ncbi.nlm.nih.gov/pubmed/31511003 https://doi.org/10.1186/s12890-019-0928-1 |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739986/ http://www.ncbi.nlm.nih.gov/pubmed/31511003 http://dx.doi.org/10.1186/s12890-019-0928-1 |
op_rights |
© The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
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CC0 PDM CC-BY |
op_doi |
https://doi.org/10.1186/s12890-019-0928-1 |
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BMC Pulmonary Medicine |
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19 |
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