Assessment of the LeadCare® Plus for Use on Scandinavian Brown Bears (Ursus arctos)
Lead (Pb) exposure is associated with adverse health effects in both humans and wildlife. Blood lead levels (BLL) of sentinel wildlife species can be used to monitor environmental lead exposure and ecosystem health. BLL analyzers, such as the LeadCare®, are validated for use in humans, assessed for...
Published in: | Frontiers in Veterinary Science |
---|---|
Main Authors: | , , , , , , |
Format: | Text |
Language: | English |
Published: |
Frontiers Media S.A.
2019
|
Subjects: | |
Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736588/ http://www.ncbi.nlm.nih.gov/pubmed/31552279 https://doi.org/10.3389/fvets.2019.00285 |
id |
ftpubmed:oai:pubmedcentral.nih.gov:6736588 |
---|---|
record_format |
openpolar |
spelling |
ftpubmed:oai:pubmedcentral.nih.gov:6736588 2023-05-15T18:41:55+02:00 Assessment of the LeadCare® Plus for Use on Scandinavian Brown Bears (Ursus arctos) Boesen, Amanda H. Thiel, Alexandra Fuchs, Boris Evans, Alina L. Bertelsen, Mads F. Rodushkin, Ilia Arnemo, Jon M. 2019-08-28 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736588/ http://www.ncbi.nlm.nih.gov/pubmed/31552279 https://doi.org/10.3389/fvets.2019.00285 en eng Frontiers Media S.A. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736588/ http://www.ncbi.nlm.nih.gov/pubmed/31552279 http://dx.doi.org/10.3389/fvets.2019.00285 Copyright © 2019 Boesen, Thiel, Fuchs, Evans, Bertelsen, Rodushkin and Arnemo. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. CC-BY Veterinary Science Text 2019 ftpubmed https://doi.org/10.3389/fvets.2019.00285 2019-09-29T00:13:51Z Lead (Pb) exposure is associated with adverse health effects in both humans and wildlife. Blood lead levels (BLL) of sentinel wildlife species can be used to monitor environmental lead exposure and ecosystem health. BLL analyzers, such as the LeadCare®, are validated for use in humans, assessed for use in some avian species and cattle, and are increasingly being used on wildlife to monitor lead exposure. The LeadCare® analyzers use a technique called anodic stripping voltammetry (ASV). Species-specific conversion equations have been proposed to approximate the levels found with gold standard measuring methods such as inductively coupled plasma mass spectrometry (ICP-MS) because the ASV method has been shown to underestimate BLL in some species. In this study we assessed the LeadCare® Plus (LCP) for use on Scandinavian brown bears (Ursus arctos). LCP measurements were correlated with ICP-MS with a Bland-Altman analyzed bias of 16.3–22.5%, showing a consistent overestimation of BLL analyzed with LCP. Based on this analysis we provide conversion equations for calculating ICP-MS BLL based on the LCP results in Scandinavian brown bears. Our study shows that the LeadCare® Plus can be used for monitoring of lead exposure by approximating gold standard levels using conversion equations. This enables comparison with other gold standard measured BLL within the observed range of this study (38.20–174.00 μg/L). Our study also found that Scandinavian brown bears are highly exposed to environmental lead. Text Ursus arctos PubMed Central (PMC) Frontiers in Veterinary Science 6 |
institution |
Open Polar |
collection |
PubMed Central (PMC) |
op_collection_id |
ftpubmed |
language |
English |
topic |
Veterinary Science |
spellingShingle |
Veterinary Science Boesen, Amanda H. Thiel, Alexandra Fuchs, Boris Evans, Alina L. Bertelsen, Mads F. Rodushkin, Ilia Arnemo, Jon M. Assessment of the LeadCare® Plus for Use on Scandinavian Brown Bears (Ursus arctos) |
topic_facet |
Veterinary Science |
description |
Lead (Pb) exposure is associated with adverse health effects in both humans and wildlife. Blood lead levels (BLL) of sentinel wildlife species can be used to monitor environmental lead exposure and ecosystem health. BLL analyzers, such as the LeadCare®, are validated for use in humans, assessed for use in some avian species and cattle, and are increasingly being used on wildlife to monitor lead exposure. The LeadCare® analyzers use a technique called anodic stripping voltammetry (ASV). Species-specific conversion equations have been proposed to approximate the levels found with gold standard measuring methods such as inductively coupled plasma mass spectrometry (ICP-MS) because the ASV method has been shown to underestimate BLL in some species. In this study we assessed the LeadCare® Plus (LCP) for use on Scandinavian brown bears (Ursus arctos). LCP measurements were correlated with ICP-MS with a Bland-Altman analyzed bias of 16.3–22.5%, showing a consistent overestimation of BLL analyzed with LCP. Based on this analysis we provide conversion equations for calculating ICP-MS BLL based on the LCP results in Scandinavian brown bears. Our study shows that the LeadCare® Plus can be used for monitoring of lead exposure by approximating gold standard levels using conversion equations. This enables comparison with other gold standard measured BLL within the observed range of this study (38.20–174.00 μg/L). Our study also found that Scandinavian brown bears are highly exposed to environmental lead. |
format |
Text |
author |
Boesen, Amanda H. Thiel, Alexandra Fuchs, Boris Evans, Alina L. Bertelsen, Mads F. Rodushkin, Ilia Arnemo, Jon M. |
author_facet |
Boesen, Amanda H. Thiel, Alexandra Fuchs, Boris Evans, Alina L. Bertelsen, Mads F. Rodushkin, Ilia Arnemo, Jon M. |
author_sort |
Boesen, Amanda H. |
title |
Assessment of the LeadCare® Plus for Use on Scandinavian Brown Bears (Ursus arctos) |
title_short |
Assessment of the LeadCare® Plus for Use on Scandinavian Brown Bears (Ursus arctos) |
title_full |
Assessment of the LeadCare® Plus for Use on Scandinavian Brown Bears (Ursus arctos) |
title_fullStr |
Assessment of the LeadCare® Plus for Use on Scandinavian Brown Bears (Ursus arctos) |
title_full_unstemmed |
Assessment of the LeadCare® Plus for Use on Scandinavian Brown Bears (Ursus arctos) |
title_sort |
assessment of the leadcare® plus for use on scandinavian brown bears (ursus arctos) |
publisher |
Frontiers Media S.A. |
publishDate |
2019 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736588/ http://www.ncbi.nlm.nih.gov/pubmed/31552279 https://doi.org/10.3389/fvets.2019.00285 |
genre |
Ursus arctos |
genre_facet |
Ursus arctos |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736588/ http://www.ncbi.nlm.nih.gov/pubmed/31552279 http://dx.doi.org/10.3389/fvets.2019.00285 |
op_rights |
Copyright © 2019 Boesen, Thiel, Fuchs, Evans, Bertelsen, Rodushkin and Arnemo. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.3389/fvets.2019.00285 |
container_title |
Frontiers in Veterinary Science |
container_volume |
6 |
_version_ |
1766231495336263680 |