Toxic metals in cord blood and later development of Type 1 diabetes
The incidence of type 1 diabetes (T1D) has increased explained by changes in environment or lifestyle. In modern society dissemination of heavy metals has increased. As the autoimmune process usually starts already, we hypothesized that exposure to toxic metals during fetal life might contribute to...
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ftpubmed:oai:pubmedcentral.nih.gov:6687082 2023-05-15T17:09:11+02:00 Toxic metals in cord blood and later development of Type 1 diabetes Ludvigsson, J Andersson-White, P Guerrero-Bosagna, C 2019-05-24 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6687082/ en eng http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6687082/ http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. CC-BY Article Text 2019 ftpubmed 2019-08-18T00:49:18Z The incidence of type 1 diabetes (T1D) has increased explained by changes in environment or lifestyle. In modern society dissemination of heavy metals has increased. As the autoimmune process usually starts already, we hypothesized that exposure to toxic metals during fetal life might contribute to development of T1D in children. We analysed arsenic (AS), aluminium (Al), cadmium (Cd), lithium (Li), mercury (Hg), lead (Pb), in cord blood of 20 children who later developed T1D (probands), and in 40 age-and sex-matched controls. Analysis of heavy metals in cord blood was performed by ALS Scandinavia AB (Luleå, Sweden) using the ‘ultrasensitive inductively coupled plasma sector field mass spectrometry method’ (ICP-SFMS) after acid digestion with HNO(3). Most children had no increased concentrations of the metals in cord blood. However, children who later developed T1D had more often increased concentrations (above limit of detection; LOD) of aluminium (p = 0.006) in cord blood than the non-diabetic controls, and also more often mercury and arsenic (n.s). Our conclusion is that exposure to toxic metals during pregnancy might be one among several contributing environmental factors to the disease process if confirmed in other birth cohort trials. Text Luleå Luleå Luleå PubMed Central (PMC) |
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Article Ludvigsson, J Andersson-White, P Guerrero-Bosagna, C Toxic metals in cord blood and later development of Type 1 diabetes |
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The incidence of type 1 diabetes (T1D) has increased explained by changes in environment or lifestyle. In modern society dissemination of heavy metals has increased. As the autoimmune process usually starts already, we hypothesized that exposure to toxic metals during fetal life might contribute to development of T1D in children. We analysed arsenic (AS), aluminium (Al), cadmium (Cd), lithium (Li), mercury (Hg), lead (Pb), in cord blood of 20 children who later developed T1D (probands), and in 40 age-and sex-matched controls. Analysis of heavy metals in cord blood was performed by ALS Scandinavia AB (Luleå, Sweden) using the ‘ultrasensitive inductively coupled plasma sector field mass spectrometry method’ (ICP-SFMS) after acid digestion with HNO(3). Most children had no increased concentrations of the metals in cord blood. However, children who later developed T1D had more often increased concentrations (above limit of detection; LOD) of aluminium (p = 0.006) in cord blood than the non-diabetic controls, and also more often mercury and arsenic (n.s). Our conclusion is that exposure to toxic metals during pregnancy might be one among several contributing environmental factors to the disease process if confirmed in other birth cohort trials. |
format |
Text |
author |
Ludvigsson, J Andersson-White, P Guerrero-Bosagna, C |
author_facet |
Ludvigsson, J Andersson-White, P Guerrero-Bosagna, C |
author_sort |
Ludvigsson, J |
title |
Toxic metals in cord blood and later development of Type 1 diabetes |
title_short |
Toxic metals in cord blood and later development of Type 1 diabetes |
title_full |
Toxic metals in cord blood and later development of Type 1 diabetes |
title_fullStr |
Toxic metals in cord blood and later development of Type 1 diabetes |
title_full_unstemmed |
Toxic metals in cord blood and later development of Type 1 diabetes |
title_sort |
toxic metals in cord blood and later development of type 1 diabetes |
publishDate |
2019 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6687082/ |
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Luleå Luleå Luleå |
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Luleå Luleå Luleå |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6687082/ |
op_rights |
http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
op_rightsnorm |
CC-BY |
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1766065151531810816 |