Marine Morbilliviruses: Diversity and Interaction with Signaling Lymphocyte Activation Molecules
Epidemiological reports of phocine distemper virus (PDV) and cetacean morbillivirus (CeMV) have accumulated since their discovery nearly 30 years ago. In this review, we focus on the interaction between these marine morbilliviruses and their major cellular receptor, the signaling lymphocyte activati...
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ftpubmed:oai:pubmedcentral.nih.gov:6669707 2023-05-15T15:37:09+02:00 Marine Morbilliviruses: Diversity and Interaction with Signaling Lymphocyte Activation Molecules Ohishi, Kazue Maruyama, Tadashi Seki, Fumio Takeda, Makoto 2019-07-03 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669707/ http://www.ncbi.nlm.nih.gov/pubmed/31277275 https://doi.org/10.3390/v11070606 en eng MDPI http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669707/ http://www.ncbi.nlm.nih.gov/pubmed/31277275 http://dx.doi.org/10.3390/v11070606 © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). CC-BY Review Text 2019 ftpubmed https://doi.org/10.3390/v11070606 2019-08-18T00:32:05Z Epidemiological reports of phocine distemper virus (PDV) and cetacean morbillivirus (CeMV) have accumulated since their discovery nearly 30 years ago. In this review, we focus on the interaction between these marine morbilliviruses and their major cellular receptor, the signaling lymphocyte activation molecule (SLAM). The three-dimensional crystal structure and homology models of SLAMs have demonstrated that 35 residues are important for binding to the morbillivirus hemagglutinin (H) protein and contribute to viral tropism. These 35 residues are essentially conserved among pinnipeds and highly conserved among the Caniformia, suggesting that PDV can infect these animals, but are less conserved among cetaceans. Because CeMV can infect various cetacean species, including toothed and baleen whales, the CeMV-H protein is postulated to have broader specificity to accommodate more divergent SLAM interfaces and may enable the virus to infect seals. In silico analysis of viral H protein and SLAM indicates that each residue of the H protein interacts with multiple residues of SLAM and vice versa. The integration of epidemiological, virological, structural, and computational studies should provide deeper insight into host specificity and switching of marine morbilliviruses. Text baleen whales PubMed Central (PMC) Viruses 11 7 606 |
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Review Ohishi, Kazue Maruyama, Tadashi Seki, Fumio Takeda, Makoto Marine Morbilliviruses: Diversity and Interaction with Signaling Lymphocyte Activation Molecules |
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Review |
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Epidemiological reports of phocine distemper virus (PDV) and cetacean morbillivirus (CeMV) have accumulated since their discovery nearly 30 years ago. In this review, we focus on the interaction between these marine morbilliviruses and their major cellular receptor, the signaling lymphocyte activation molecule (SLAM). The three-dimensional crystal structure and homology models of SLAMs have demonstrated that 35 residues are important for binding to the morbillivirus hemagglutinin (H) protein and contribute to viral tropism. These 35 residues are essentially conserved among pinnipeds and highly conserved among the Caniformia, suggesting that PDV can infect these animals, but are less conserved among cetaceans. Because CeMV can infect various cetacean species, including toothed and baleen whales, the CeMV-H protein is postulated to have broader specificity to accommodate more divergent SLAM interfaces and may enable the virus to infect seals. In silico analysis of viral H protein and SLAM indicates that each residue of the H protein interacts with multiple residues of SLAM and vice versa. The integration of epidemiological, virological, structural, and computational studies should provide deeper insight into host specificity and switching of marine morbilliviruses. |
format |
Text |
author |
Ohishi, Kazue Maruyama, Tadashi Seki, Fumio Takeda, Makoto |
author_facet |
Ohishi, Kazue Maruyama, Tadashi Seki, Fumio Takeda, Makoto |
author_sort |
Ohishi, Kazue |
title |
Marine Morbilliviruses: Diversity and Interaction with Signaling Lymphocyte Activation Molecules |
title_short |
Marine Morbilliviruses: Diversity and Interaction with Signaling Lymphocyte Activation Molecules |
title_full |
Marine Morbilliviruses: Diversity and Interaction with Signaling Lymphocyte Activation Molecules |
title_fullStr |
Marine Morbilliviruses: Diversity and Interaction with Signaling Lymphocyte Activation Molecules |
title_full_unstemmed |
Marine Morbilliviruses: Diversity and Interaction with Signaling Lymphocyte Activation Molecules |
title_sort |
marine morbilliviruses: diversity and interaction with signaling lymphocyte activation molecules |
publisher |
MDPI |
publishDate |
2019 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669707/ http://www.ncbi.nlm.nih.gov/pubmed/31277275 https://doi.org/10.3390/v11070606 |
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baleen whales |
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baleen whales |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669707/ http://www.ncbi.nlm.nih.gov/pubmed/31277275 http://dx.doi.org/10.3390/v11070606 |
op_rights |
© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
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CC-BY |
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https://doi.org/10.3390/v11070606 |
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