Antibiotic dispensation rates among participants in community-driven health research projects in Arctic Canada
BACKGROUND: Community-driven projects that aim to address public concerns about health risks from H. pylori infection in Indigenous Arctic communities (estimated H. pylori prevalence = 64%) show frequent failure of treatment to eliminate the bacterium. Among project participants, treatment effective...
Published in: | BMC Public Health |
---|---|
Main Authors: | , , , |
Format: | Text |
Language: | English |
Published: |
BioMed Central
2019
|
Subjects: | |
Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631451/ http://www.ncbi.nlm.nih.gov/pubmed/31307422 https://doi.org/10.1186/s12889-019-7193-3 |
id |
ftpubmed:oai:pubmedcentral.nih.gov:6631451 |
---|---|
record_format |
openpolar |
spelling |
ftpubmed:oai:pubmedcentral.nih.gov:6631451 2023-05-15T13:08:01+02:00 Antibiotic dispensation rates among participants in community-driven health research projects in Arctic Canada Williams, Kathleen Colquhoun, Amy Munday, Rachel Goodman, Karen J. 2019-07-15 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631451/ http://www.ncbi.nlm.nih.gov/pubmed/31307422 https://doi.org/10.1186/s12889-019-7193-3 en eng BioMed Central http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631451/ http://www.ncbi.nlm.nih.gov/pubmed/31307422 http://dx.doi.org/10.1186/s12889-019-7193-3 © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. CC0 PDM CC-BY Research Article Text 2019 ftpubmed https://doi.org/10.1186/s12889-019-7193-3 2019-08-04T00:44:07Z BACKGROUND: Community-driven projects that aim to address public concerns about health risks from H. pylori infection in Indigenous Arctic communities (estimated H. pylori prevalence = 64%) show frequent failure of treatment to eliminate the bacterium. Among project participants, treatment effectiveness is reduced by antibiotic resistance of infecting H. pylori strains, which in turn, is associated with frequent exposure to antibiotics used to treat other infections. This analysis compares antibiotic dispensation rates in Canadian Arctic communities to rates in urban and rural populations in Alberta, a southern Canadian province. METHODS: Project staff collected antibiotic exposure histories for 297 participants enrolled during 2007–2012 in Aklavik, Tuktoyaktuk, and Fort McPherson in the Northwest Territories, and Old Crow, Yukon. Medical chart reviews collected data on systemic antibiotic dispensations for the 5-year period before enrolment for each participant. Antibiotic dispensation data for urban Edmonton, Alberta (average population ~ 860,000) and rural northern Alberta (average population ~ 450,000) during 2010–2013 were obtained from the Alberta Government Interactive Health Data Application. RESULTS: Antibiotic dispensation rates, estimated as dispensations/person-years (95% confidence interval) were: in Arctic communities, 0.89 (0.84, 0.94); in Edmonton, 0.55 (0.55, 0.56); in rural northern Alberta, 0.63 (0.62, 0.63). Antibiotic dispensation rates were higher in women and older age groups in all regions. In all regions, the highest dispensation rates occurred for β-lactam and macrolide antibiotic classes. CONCLUSIONS: These results show more frequent antibiotic dispensation in Arctic communities relative to an urban and rural southern Canadian population. Text Aklavik Arctic Fort McPherson Northwest Territories Old Crow Tuktoyaktuk Yukon PubMed Central (PMC) Aklavik ENVELOPE(-135.011,-135.011,68.219,68.219) Arctic Canada Fort McPherson ENVELOPE(-134.826,-134.826,67.433,67.433) Northwest Territories Tuktoyaktuk ENVELOPE(-133.006,-133.006,69.425,69.425) Yukon BMC Public Health 19 1 |
institution |
Open Polar |
collection |
PubMed Central (PMC) |
op_collection_id |
ftpubmed |
language |
English |
topic |
Research Article |
spellingShingle |
Research Article Williams, Kathleen Colquhoun, Amy Munday, Rachel Goodman, Karen J. Antibiotic dispensation rates among participants in community-driven health research projects in Arctic Canada |
topic_facet |
Research Article |
description |
BACKGROUND: Community-driven projects that aim to address public concerns about health risks from H. pylori infection in Indigenous Arctic communities (estimated H. pylori prevalence = 64%) show frequent failure of treatment to eliminate the bacterium. Among project participants, treatment effectiveness is reduced by antibiotic resistance of infecting H. pylori strains, which in turn, is associated with frequent exposure to antibiotics used to treat other infections. This analysis compares antibiotic dispensation rates in Canadian Arctic communities to rates in urban and rural populations in Alberta, a southern Canadian province. METHODS: Project staff collected antibiotic exposure histories for 297 participants enrolled during 2007–2012 in Aklavik, Tuktoyaktuk, and Fort McPherson in the Northwest Territories, and Old Crow, Yukon. Medical chart reviews collected data on systemic antibiotic dispensations for the 5-year period before enrolment for each participant. Antibiotic dispensation data for urban Edmonton, Alberta (average population ~ 860,000) and rural northern Alberta (average population ~ 450,000) during 2010–2013 were obtained from the Alberta Government Interactive Health Data Application. RESULTS: Antibiotic dispensation rates, estimated as dispensations/person-years (95% confidence interval) were: in Arctic communities, 0.89 (0.84, 0.94); in Edmonton, 0.55 (0.55, 0.56); in rural northern Alberta, 0.63 (0.62, 0.63). Antibiotic dispensation rates were higher in women and older age groups in all regions. In all regions, the highest dispensation rates occurred for β-lactam and macrolide antibiotic classes. CONCLUSIONS: These results show more frequent antibiotic dispensation in Arctic communities relative to an urban and rural southern Canadian population. |
format |
Text |
author |
Williams, Kathleen Colquhoun, Amy Munday, Rachel Goodman, Karen J. |
author_facet |
Williams, Kathleen Colquhoun, Amy Munday, Rachel Goodman, Karen J. |
author_sort |
Williams, Kathleen |
title |
Antibiotic dispensation rates among participants in community-driven health research projects in Arctic Canada |
title_short |
Antibiotic dispensation rates among participants in community-driven health research projects in Arctic Canada |
title_full |
Antibiotic dispensation rates among participants in community-driven health research projects in Arctic Canada |
title_fullStr |
Antibiotic dispensation rates among participants in community-driven health research projects in Arctic Canada |
title_full_unstemmed |
Antibiotic dispensation rates among participants in community-driven health research projects in Arctic Canada |
title_sort |
antibiotic dispensation rates among participants in community-driven health research projects in arctic canada |
publisher |
BioMed Central |
publishDate |
2019 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631451/ http://www.ncbi.nlm.nih.gov/pubmed/31307422 https://doi.org/10.1186/s12889-019-7193-3 |
long_lat |
ENVELOPE(-135.011,-135.011,68.219,68.219) ENVELOPE(-134.826,-134.826,67.433,67.433) ENVELOPE(-133.006,-133.006,69.425,69.425) |
geographic |
Aklavik Arctic Canada Fort McPherson Northwest Territories Tuktoyaktuk Yukon |
geographic_facet |
Aklavik Arctic Canada Fort McPherson Northwest Territories Tuktoyaktuk Yukon |
genre |
Aklavik Arctic Fort McPherson Northwest Territories Old Crow Tuktoyaktuk Yukon |
genre_facet |
Aklavik Arctic Fort McPherson Northwest Territories Old Crow Tuktoyaktuk Yukon |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631451/ http://www.ncbi.nlm.nih.gov/pubmed/31307422 http://dx.doi.org/10.1186/s12889-019-7193-3 |
op_rights |
© The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
op_rightsnorm |
CC0 PDM CC-BY |
op_doi |
https://doi.org/10.1186/s12889-019-7193-3 |
container_title |
BMC Public Health |
container_volume |
19 |
container_issue |
1 |
_version_ |
1766071959175561216 |