Potential TSPO Ligand and Photooxidation Quencher Isorenieratene from Arctic Ocean Rhodococcus sp. B7740
Due to its special aromatic structure, isorenieratene is thought to be an active natural antioxidant and photo/UV damage inhibitor. In this work, isorenieratene that was extracted from Rhodococcus sp. B7740 isolated from the Arctic Ocean, showed excellent scavenging ability of both singlet oxygen an...
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ftpubmed:oai:pubmedcentral.nih.gov:6627809 2023-05-15T14:54:03+02:00 Potential TSPO Ligand and Photooxidation Quencher Isorenieratene from Arctic Ocean Rhodococcus sp. B7740 Chen, Yashu Guo, Mengyao Yang, Jifang Chen, Jigang Xie, Bijun Sun, Zhida 2019-05-29 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627809/ http://www.ncbi.nlm.nih.gov/pubmed/31146377 https://doi.org/10.3390/md17060316 en eng MDPI http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627809/ http://www.ncbi.nlm.nih.gov/pubmed/31146377 http://dx.doi.org/10.3390/md17060316 © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). CC-BY Article Text 2019 ftpubmed https://doi.org/10.3390/md17060316 2019-08-04T00:39:59Z Due to its special aromatic structure, isorenieratene is thought to be an active natural antioxidant and photo/UV damage inhibitor. In this work, isorenieratene that was extracted from Rhodococcus sp. B7740 isolated from the Arctic Ocean, showed excellent scavenging ability of both singlet oxygen and hydroxyl radical in the UVB-induced auto-oxidation process using the EPR method. Within an ARPE-19 cell model damaged by UVB radiation, isorenieratene showed fine protective effects (1.13 ± 0.03 fold) compared with macular xanthophylls (MXs) through upregulating of tspo. The molecular docking was firstly performed to investigate the interaction of isorenieratene with TSPO as a special ligand. Results showed isorenieratene might form a better binding conformation (S-score −8.5438) than MXs and indicate that isorenieratene not only can function as a direct antioxidant but also activate tspo in ARPE-19 cells. Thus, isorenieratene might ease the UV-related damages including age-related macular degeneration (AMD). Text Arctic Arctic Ocean PubMed Central (PMC) Arctic Arctic Ocean Marine Drugs 17 6 316 |
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Article Chen, Yashu Guo, Mengyao Yang, Jifang Chen, Jigang Xie, Bijun Sun, Zhida Potential TSPO Ligand and Photooxidation Quencher Isorenieratene from Arctic Ocean Rhodococcus sp. B7740 |
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Due to its special aromatic structure, isorenieratene is thought to be an active natural antioxidant and photo/UV damage inhibitor. In this work, isorenieratene that was extracted from Rhodococcus sp. B7740 isolated from the Arctic Ocean, showed excellent scavenging ability of both singlet oxygen and hydroxyl radical in the UVB-induced auto-oxidation process using the EPR method. Within an ARPE-19 cell model damaged by UVB radiation, isorenieratene showed fine protective effects (1.13 ± 0.03 fold) compared with macular xanthophylls (MXs) through upregulating of tspo. The molecular docking was firstly performed to investigate the interaction of isorenieratene with TSPO as a special ligand. Results showed isorenieratene might form a better binding conformation (S-score −8.5438) than MXs and indicate that isorenieratene not only can function as a direct antioxidant but also activate tspo in ARPE-19 cells. Thus, isorenieratene might ease the UV-related damages including age-related macular degeneration (AMD). |
format |
Text |
author |
Chen, Yashu Guo, Mengyao Yang, Jifang Chen, Jigang Xie, Bijun Sun, Zhida |
author_facet |
Chen, Yashu Guo, Mengyao Yang, Jifang Chen, Jigang Xie, Bijun Sun, Zhida |
author_sort |
Chen, Yashu |
title |
Potential TSPO Ligand and Photooxidation Quencher Isorenieratene from Arctic Ocean Rhodococcus sp. B7740 |
title_short |
Potential TSPO Ligand and Photooxidation Quencher Isorenieratene from Arctic Ocean Rhodococcus sp. B7740 |
title_full |
Potential TSPO Ligand and Photooxidation Quencher Isorenieratene from Arctic Ocean Rhodococcus sp. B7740 |
title_fullStr |
Potential TSPO Ligand and Photooxidation Quencher Isorenieratene from Arctic Ocean Rhodococcus sp. B7740 |
title_full_unstemmed |
Potential TSPO Ligand and Photooxidation Quencher Isorenieratene from Arctic Ocean Rhodococcus sp. B7740 |
title_sort |
potential tspo ligand and photooxidation quencher isorenieratene from arctic ocean rhodococcus sp. b7740 |
publisher |
MDPI |
publishDate |
2019 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627809/ http://www.ncbi.nlm.nih.gov/pubmed/31146377 https://doi.org/10.3390/md17060316 |
geographic |
Arctic Arctic Ocean |
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Arctic Arctic Ocean |
genre |
Arctic Arctic Ocean |
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Arctic Arctic Ocean |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627809/ http://www.ncbi.nlm.nih.gov/pubmed/31146377 http://dx.doi.org/10.3390/md17060316 |
op_rights |
© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
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CC-BY |
op_doi |
https://doi.org/10.3390/md17060316 |
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Marine Drugs |
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316 |
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