Fermented Oyster Extract Prevents Ovariectomy-Induced Bone Loss and Suppresses Osteoclastogenesis
There is growing interest in bioactive substances from marine organisms for their potential use against diverse human diseases. Osteoporosis is a skeletal disorder associated with bone loss primarily occurring through enhanced osteoclast differentiation and resorption. Recently, we reported the anti...
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ftpubmed:oai:pubmedcentral.nih.gov:6627411 2023-05-15T15:58:40+02:00 Fermented Oyster Extract Prevents Ovariectomy-Induced Bone Loss and Suppresses Osteoclastogenesis Ihn, Hye Jung Kim, Ju Ang Lim, Soomin Nam, Sang-Hyeon Hwang, So Hyeon Lim, Jiwon Kim, Gi-Young Choi, Yung Hyun Jeon, You-Jin Lee, Bae-Jin Bae, Jong-Sup Kim, Yeo Hyang Park, Eui Kyun 2019-06-21 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627411/ http://www.ncbi.nlm.nih.gov/pubmed/31234292 https://doi.org/10.3390/nu11061392 en eng MDPI http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627411/ http://www.ncbi.nlm.nih.gov/pubmed/31234292 http://dx.doi.org/10.3390/nu11061392 © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). CC-BY Article Text 2019 ftpubmed https://doi.org/10.3390/nu11061392 2019-08-04T00:39:02Z There is growing interest in bioactive substances from marine organisms for their potential use against diverse human diseases. Osteoporosis is a skeletal disorder associated with bone loss primarily occurring through enhanced osteoclast differentiation and resorption. Recently, we reported the anti-osteoclastogenic activity of fermented Pacific oyster (Crassostrea gigas) extract (FO) in vitro. The present study focused on investigating the anti-osteoporotic efficacy of FO in bone loss prevention in an experimental animal model of osteoporosis and elucidating the mechanism underlying its effects. Oral administration of FO significantly decreased ovariectomy-induced osteoclast formation and prevented bone loss, with reduced serum levels of bone turnover biomarkers including osteocalcin and C-terminal telopeptide fragment of type I collagen C-terminus (CTX). FO significantly suppressed receptor activator of nuclear factor-κB ligand (RANKL)-induced differentiation of bone marrow-derived macrophages (BMMs) into osteoclasts and attenuated the induction of osteoclast-specific genes required for osteoclastogenesis and bone resorption. Furthermore, FO inhibited RANKL-mediated IκBα and p65 phosphorylation in BMMs. Taken together, these results demonstrate that FO effectively suppresses osteoclastogenesis in vivo and in vitro, and that FO can be considered as a potential therapeutic option for the treatment of osteoporosis and osteoclast-mediated skeletal diseases. Text Crassostrea gigas Pacific oyster PubMed Central (PMC) Pacific Nutrients 11 6 1392 |
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Article Ihn, Hye Jung Kim, Ju Ang Lim, Soomin Nam, Sang-Hyeon Hwang, So Hyeon Lim, Jiwon Kim, Gi-Young Choi, Yung Hyun Jeon, You-Jin Lee, Bae-Jin Bae, Jong-Sup Kim, Yeo Hyang Park, Eui Kyun Fermented Oyster Extract Prevents Ovariectomy-Induced Bone Loss and Suppresses Osteoclastogenesis |
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Article |
description |
There is growing interest in bioactive substances from marine organisms for their potential use against diverse human diseases. Osteoporosis is a skeletal disorder associated with bone loss primarily occurring through enhanced osteoclast differentiation and resorption. Recently, we reported the anti-osteoclastogenic activity of fermented Pacific oyster (Crassostrea gigas) extract (FO) in vitro. The present study focused on investigating the anti-osteoporotic efficacy of FO in bone loss prevention in an experimental animal model of osteoporosis and elucidating the mechanism underlying its effects. Oral administration of FO significantly decreased ovariectomy-induced osteoclast formation and prevented bone loss, with reduced serum levels of bone turnover biomarkers including osteocalcin and C-terminal telopeptide fragment of type I collagen C-terminus (CTX). FO significantly suppressed receptor activator of nuclear factor-κB ligand (RANKL)-induced differentiation of bone marrow-derived macrophages (BMMs) into osteoclasts and attenuated the induction of osteoclast-specific genes required for osteoclastogenesis and bone resorption. Furthermore, FO inhibited RANKL-mediated IκBα and p65 phosphorylation in BMMs. Taken together, these results demonstrate that FO effectively suppresses osteoclastogenesis in vivo and in vitro, and that FO can be considered as a potential therapeutic option for the treatment of osteoporosis and osteoclast-mediated skeletal diseases. |
format |
Text |
author |
Ihn, Hye Jung Kim, Ju Ang Lim, Soomin Nam, Sang-Hyeon Hwang, So Hyeon Lim, Jiwon Kim, Gi-Young Choi, Yung Hyun Jeon, You-Jin Lee, Bae-Jin Bae, Jong-Sup Kim, Yeo Hyang Park, Eui Kyun |
author_facet |
Ihn, Hye Jung Kim, Ju Ang Lim, Soomin Nam, Sang-Hyeon Hwang, So Hyeon Lim, Jiwon Kim, Gi-Young Choi, Yung Hyun Jeon, You-Jin Lee, Bae-Jin Bae, Jong-Sup Kim, Yeo Hyang Park, Eui Kyun |
author_sort |
Ihn, Hye Jung |
title |
Fermented Oyster Extract Prevents Ovariectomy-Induced Bone Loss and Suppresses Osteoclastogenesis |
title_short |
Fermented Oyster Extract Prevents Ovariectomy-Induced Bone Loss and Suppresses Osteoclastogenesis |
title_full |
Fermented Oyster Extract Prevents Ovariectomy-Induced Bone Loss and Suppresses Osteoclastogenesis |
title_fullStr |
Fermented Oyster Extract Prevents Ovariectomy-Induced Bone Loss and Suppresses Osteoclastogenesis |
title_full_unstemmed |
Fermented Oyster Extract Prevents Ovariectomy-Induced Bone Loss and Suppresses Osteoclastogenesis |
title_sort |
fermented oyster extract prevents ovariectomy-induced bone loss and suppresses osteoclastogenesis |
publisher |
MDPI |
publishDate |
2019 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627411/ http://www.ncbi.nlm.nih.gov/pubmed/31234292 https://doi.org/10.3390/nu11061392 |
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Pacific |
geographic_facet |
Pacific |
genre |
Crassostrea gigas Pacific oyster |
genre_facet |
Crassostrea gigas Pacific oyster |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627411/ http://www.ncbi.nlm.nih.gov/pubmed/31234292 http://dx.doi.org/10.3390/nu11061392 |
op_rights |
© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.3390/nu11061392 |
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Nutrients |
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11 |
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6 |
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1392 |
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