Bone resorption and body reorganization during maturation induce maternal transfer of toxic metals in anguillid eels
During their once-in-a-lifetime transoceanic spawning migration, anguillid eels do not feed, instead rely on energy stores to fuel the demands of locomotion and reproduction while they reorganize their bodies by depleting body reserves and building up gonadal tissue. Here we show how the European ee...
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Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561237/ http://www.ncbi.nlm.nih.gov/pubmed/31085642 https://doi.org/10.1073/pnas.1817738116 |
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ftpubmed:oai:pubmedcentral.nih.gov:6561237 2023-05-15T13:27:54+02:00 Bone resorption and body reorganization during maturation induce maternal transfer of toxic metals in anguillid eels Freese, Marko Rizzo, Larissa Yokota Pohlmann, Jan-Dag Marohn, Lasse Witten, Paul Eckhard Gremse, Felix Rütten, Stephan Güvener, Nihan Michael, Sabrina Wysujack, Klaus Lammers, Twan Kiessling, Fabian Hollert, Henner Hanel, Reinhold Brinkmann, Markus 2019-06-04 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561237/ http://www.ncbi.nlm.nih.gov/pubmed/31085642 https://doi.org/10.1073/pnas.1817738116 en eng National Academy of Sciences http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561237/ http://www.ncbi.nlm.nih.gov/pubmed/31085642 http://dx.doi.org/10.1073/pnas.1817738116 Copyright © 2019 the Author(s). Published by PNAS. https://creativecommons.org/licenses/by-nc-nd/4.0/ https://creativecommons.org/licenses/by-nc-nd/4.0/This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) . CC-BY-NC-ND Biological Sciences Text 2019 ftpubmed https://doi.org/10.1073/pnas.1817738116 2019-06-23T00:21:52Z During their once-in-a-lifetime transoceanic spawning migration, anguillid eels do not feed, instead rely on energy stores to fuel the demands of locomotion and reproduction while they reorganize their bodies by depleting body reserves and building up gonadal tissue. Here we show how the European eel (Anguilla anguilla) breaks down its skeleton to redistribute phosphorus and calcium from hard to soft tissues during its sexual development. Using multiple analytical and imaging techniques, we characterize the spatial and temporal degradation of the skeletal framework from initial to final gonadal maturation and use elemental mass ratios in bone, muscle, liver, and gonadal tissue to determine the fluxes and fates of selected minerals and metals in the eels’ bodies. We find that bone loss is more pronounced in females than in males and eventually may reach a point at which the mechanical stability of the skeleton is challenged. P and Ca are released and translocated from skeletal tissues to muscle and gonads, leaving both elements in constant proportion in remaining bone structures. The depletion of internal stores from hard and soft tissues during maturation-induced body reorganization is accompanied by the recirculation, translocation, and maternal transfer of potentially toxic metals from bone and muscle to the ovaries in gravid females, which may have direct deleterious effects on health and hinder the reproductive success of individuals of this critically endangered species. Text Anguilla anguilla European eel PubMed Central (PMC) Proceedings of the National Academy of Sciences 116 23 11339 11344 |
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Biological Sciences |
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Biological Sciences Freese, Marko Rizzo, Larissa Yokota Pohlmann, Jan-Dag Marohn, Lasse Witten, Paul Eckhard Gremse, Felix Rütten, Stephan Güvener, Nihan Michael, Sabrina Wysujack, Klaus Lammers, Twan Kiessling, Fabian Hollert, Henner Hanel, Reinhold Brinkmann, Markus Bone resorption and body reorganization during maturation induce maternal transfer of toxic metals in anguillid eels |
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Biological Sciences |
description |
During their once-in-a-lifetime transoceanic spawning migration, anguillid eels do not feed, instead rely on energy stores to fuel the demands of locomotion and reproduction while they reorganize their bodies by depleting body reserves and building up gonadal tissue. Here we show how the European eel (Anguilla anguilla) breaks down its skeleton to redistribute phosphorus and calcium from hard to soft tissues during its sexual development. Using multiple analytical and imaging techniques, we characterize the spatial and temporal degradation of the skeletal framework from initial to final gonadal maturation and use elemental mass ratios in bone, muscle, liver, and gonadal tissue to determine the fluxes and fates of selected minerals and metals in the eels’ bodies. We find that bone loss is more pronounced in females than in males and eventually may reach a point at which the mechanical stability of the skeleton is challenged. P and Ca are released and translocated from skeletal tissues to muscle and gonads, leaving both elements in constant proportion in remaining bone structures. The depletion of internal stores from hard and soft tissues during maturation-induced body reorganization is accompanied by the recirculation, translocation, and maternal transfer of potentially toxic metals from bone and muscle to the ovaries in gravid females, which may have direct deleterious effects on health and hinder the reproductive success of individuals of this critically endangered species. |
format |
Text |
author |
Freese, Marko Rizzo, Larissa Yokota Pohlmann, Jan-Dag Marohn, Lasse Witten, Paul Eckhard Gremse, Felix Rütten, Stephan Güvener, Nihan Michael, Sabrina Wysujack, Klaus Lammers, Twan Kiessling, Fabian Hollert, Henner Hanel, Reinhold Brinkmann, Markus |
author_facet |
Freese, Marko Rizzo, Larissa Yokota Pohlmann, Jan-Dag Marohn, Lasse Witten, Paul Eckhard Gremse, Felix Rütten, Stephan Güvener, Nihan Michael, Sabrina Wysujack, Klaus Lammers, Twan Kiessling, Fabian Hollert, Henner Hanel, Reinhold Brinkmann, Markus |
author_sort |
Freese, Marko |
title |
Bone resorption and body reorganization during maturation induce maternal transfer of toxic metals in anguillid eels |
title_short |
Bone resorption and body reorganization during maturation induce maternal transfer of toxic metals in anguillid eels |
title_full |
Bone resorption and body reorganization during maturation induce maternal transfer of toxic metals in anguillid eels |
title_fullStr |
Bone resorption and body reorganization during maturation induce maternal transfer of toxic metals in anguillid eels |
title_full_unstemmed |
Bone resorption and body reorganization during maturation induce maternal transfer of toxic metals in anguillid eels |
title_sort |
bone resorption and body reorganization during maturation induce maternal transfer of toxic metals in anguillid eels |
publisher |
National Academy of Sciences |
publishDate |
2019 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561237/ http://www.ncbi.nlm.nih.gov/pubmed/31085642 https://doi.org/10.1073/pnas.1817738116 |
genre |
Anguilla anguilla European eel |
genre_facet |
Anguilla anguilla European eel |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561237/ http://www.ncbi.nlm.nih.gov/pubmed/31085642 http://dx.doi.org/10.1073/pnas.1817738116 |
op_rights |
Copyright © 2019 the Author(s). Published by PNAS. https://creativecommons.org/licenses/by-nc-nd/4.0/ https://creativecommons.org/licenses/by-nc-nd/4.0/This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) . |
op_rightsnorm |
CC-BY-NC-ND |
op_doi |
https://doi.org/10.1073/pnas.1817738116 |
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Proceedings of the National Academy of Sciences |
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116 |
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23 |
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11339 |
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11344 |
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1766401054654595072 |