The initiation of puberty in Atlantic salmon brings about large changes in testicular gene expression that are modulated by the energy status
BACKGROUND: When puberty starts before males reach harvest size, animal welfare and sustainability issues occur in Atlantic salmon (Salmo salar) aquaculture. Hallmarks of male puberty are an increased proliferation activity in the testis and elevated androgen production. Examining transcriptional ch...
Published in: | BMC Genomics |
---|---|
Main Authors: | , , , , , , , , , |
Format: | Text |
Language: | English |
Published: |
BioMed Central
2019
|
Subjects: | |
Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558769/ http://www.ncbi.nlm.nih.gov/pubmed/31185904 https://doi.org/10.1186/s12864-019-5869-9 |
id |
ftpubmed:oai:pubmedcentral.nih.gov:6558769 |
---|---|
record_format |
openpolar |
spelling |
ftpubmed:oai:pubmedcentral.nih.gov:6558769 2023-05-15T15:31:55+02:00 The initiation of puberty in Atlantic salmon brings about large changes in testicular gene expression that are modulated by the energy status Crespo, Diego Bogerd, Jan Sambroni, Elisabeth LeGac, Florence Andersson, Eva Edvardsen, Rolf B. Bergman, Elisabeth Jönsson Björnsson, Björn Thrandur Taranger, Geir Lasse Schulz, Rüdiger W. 2019-06-11 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558769/ http://www.ncbi.nlm.nih.gov/pubmed/31185904 https://doi.org/10.1186/s12864-019-5869-9 en eng BioMed Central http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558769/ http://www.ncbi.nlm.nih.gov/pubmed/31185904 http://dx.doi.org/10.1186/s12864-019-5869-9 © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. CC0 PDM CC-BY Research Article Text 2019 ftpubmed https://doi.org/10.1186/s12864-019-5869-9 2019-06-16T00:28:04Z BACKGROUND: When puberty starts before males reach harvest size, animal welfare and sustainability issues occur in Atlantic salmon (Salmo salar) aquaculture. Hallmarks of male puberty are an increased proliferation activity in the testis and elevated androgen production. Examining transcriptional changes in salmon testis during the transition from immature to maturing testes may help understanding the regulation of puberty, potentially leading to procedures to modulate its start. Since differences in body weight influence, via unknown mechanisms, the chances for entering puberty, we used two feed rations to create body weight differences. RESULTS: Maturing testes were characterized by an elevated proliferation activity of Sertoli cells and of single undifferentiated spermatogonia. Pituitary gene expression data suggest increased Gnrh receptor and gonadotropin gene expression, potentially responsible for the elevated circulating androgen levels in maturing fish. Transcriptional changes in maturing testes included a broad variety of signaling systems (e.g. Tgfβ, Wnt, insulin/Igf, nuclear receptors), but also, activation of metabolic pathways such as anaerobic metabolism and protection against ROS. Feed restriction lowered the incidence of puberty. In males maturing despite feed restriction, plasma androgen levels were higher than in maturing fish receiving the full ration. A group of 449 genes that were up-regulated in maturing fully fed fish, was up-regulated more prominently in testis from fish maturing under caloric restriction. Moreover, 421 genes were specifically up-regulated in testes from fish maturing under caloric restriction, including carbon metabolism genes, a pathway relevant for nucleotide biosynthesis and for placing epigenetic marks. CONCLUSIONS: Undifferentiated spermatogonia and Sertoli cell populations increased at the beginning of puberty, which was associated with the up-regulation of metabolic pathways (e.g. anaerobic and ROS pathways) known from other stem cell systems. The higher androgen ... Text Atlantic salmon Salmo salar PubMed Central (PMC) BMC Genomics 20 1 |
institution |
Open Polar |
collection |
PubMed Central (PMC) |
op_collection_id |
ftpubmed |
language |
English |
topic |
Research Article |
spellingShingle |
Research Article Crespo, Diego Bogerd, Jan Sambroni, Elisabeth LeGac, Florence Andersson, Eva Edvardsen, Rolf B. Bergman, Elisabeth Jönsson Björnsson, Björn Thrandur Taranger, Geir Lasse Schulz, Rüdiger W. The initiation of puberty in Atlantic salmon brings about large changes in testicular gene expression that are modulated by the energy status |
topic_facet |
Research Article |
description |
BACKGROUND: When puberty starts before males reach harvest size, animal welfare and sustainability issues occur in Atlantic salmon (Salmo salar) aquaculture. Hallmarks of male puberty are an increased proliferation activity in the testis and elevated androgen production. Examining transcriptional changes in salmon testis during the transition from immature to maturing testes may help understanding the regulation of puberty, potentially leading to procedures to modulate its start. Since differences in body weight influence, via unknown mechanisms, the chances for entering puberty, we used two feed rations to create body weight differences. RESULTS: Maturing testes were characterized by an elevated proliferation activity of Sertoli cells and of single undifferentiated spermatogonia. Pituitary gene expression data suggest increased Gnrh receptor and gonadotropin gene expression, potentially responsible for the elevated circulating androgen levels in maturing fish. Transcriptional changes in maturing testes included a broad variety of signaling systems (e.g. Tgfβ, Wnt, insulin/Igf, nuclear receptors), but also, activation of metabolic pathways such as anaerobic metabolism and protection against ROS. Feed restriction lowered the incidence of puberty. In males maturing despite feed restriction, plasma androgen levels were higher than in maturing fish receiving the full ration. A group of 449 genes that were up-regulated in maturing fully fed fish, was up-regulated more prominently in testis from fish maturing under caloric restriction. Moreover, 421 genes were specifically up-regulated in testes from fish maturing under caloric restriction, including carbon metabolism genes, a pathway relevant for nucleotide biosynthesis and for placing epigenetic marks. CONCLUSIONS: Undifferentiated spermatogonia and Sertoli cell populations increased at the beginning of puberty, which was associated with the up-regulation of metabolic pathways (e.g. anaerobic and ROS pathways) known from other stem cell systems. The higher androgen ... |
format |
Text |
author |
Crespo, Diego Bogerd, Jan Sambroni, Elisabeth LeGac, Florence Andersson, Eva Edvardsen, Rolf B. Bergman, Elisabeth Jönsson Björnsson, Björn Thrandur Taranger, Geir Lasse Schulz, Rüdiger W. |
author_facet |
Crespo, Diego Bogerd, Jan Sambroni, Elisabeth LeGac, Florence Andersson, Eva Edvardsen, Rolf B. Bergman, Elisabeth Jönsson Björnsson, Björn Thrandur Taranger, Geir Lasse Schulz, Rüdiger W. |
author_sort |
Crespo, Diego |
title |
The initiation of puberty in Atlantic salmon brings about large changes in testicular gene expression that are modulated by the energy status |
title_short |
The initiation of puberty in Atlantic salmon brings about large changes in testicular gene expression that are modulated by the energy status |
title_full |
The initiation of puberty in Atlantic salmon brings about large changes in testicular gene expression that are modulated by the energy status |
title_fullStr |
The initiation of puberty in Atlantic salmon brings about large changes in testicular gene expression that are modulated by the energy status |
title_full_unstemmed |
The initiation of puberty in Atlantic salmon brings about large changes in testicular gene expression that are modulated by the energy status |
title_sort |
initiation of puberty in atlantic salmon brings about large changes in testicular gene expression that are modulated by the energy status |
publisher |
BioMed Central |
publishDate |
2019 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558769/ http://www.ncbi.nlm.nih.gov/pubmed/31185904 https://doi.org/10.1186/s12864-019-5869-9 |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558769/ http://www.ncbi.nlm.nih.gov/pubmed/31185904 http://dx.doi.org/10.1186/s12864-019-5869-9 |
op_rights |
© The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
op_rightsnorm |
CC0 PDM CC-BY |
op_doi |
https://doi.org/10.1186/s12864-019-5869-9 |
container_title |
BMC Genomics |
container_volume |
20 |
container_issue |
1 |
_version_ |
1766362414149795840 |