A214 AN ANALYSIS OF FIT RESULTS AND NEOPLASTIC FINDINGS FROM THE NEWFOUNDLAND AND LABRADOR COLON CANCER SCREENING PROGRAM

• Published in: Journal of the Canadian Association of Gastroenterology
• Main Authors: Quinlan, J, Borgaonkar, M, Antle, S, Pace, D, McGrath, J S
• Format: Text
• Language: English
• Published: Oxford University Press 2018
• Subjects: Poster Presentations; Newfoundland
• Online Access: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6507602/; https://doi.org/10.1093/jcag/gwy008.215

BACKGROUND: Fecal Immunochemical Testing (FIT) is currently used in a number of Canadian provinces to screen for colorectal cancer. The Canadian Partnership Against Cancer (CPAC) recommends a FIT positive predictive value for neoplasia be >50%. Newfoundland and Labrador currently does not triage its colonoscopy waitlist for colorectal cancer screening beyond having one FIT value ≥100ng/mL. AIMS: The aim of this study is to assess the effectiveness of different FIT cut-offs and combinations of FIT cut-offs in predicting adenomas and colorectal cancer. METHODS: Data for this study was obtained in a prospective fashion using the Newfoundland and Labrador Colon Cancer Screening Program. Those enrolled in the study were between the ages of 50–74 at average risk for colon cancer. Between July 1, 2012 and June 30, 2016, participants were provided with two FIT tests – if a minimum of one test was ≥100ng/mL, participants were further evaluated via colonoscopy. Data on the patient’s age, gender, FIT value, presence of adenoma, pathology, and other variables were collected. RESULTS: Of the 21,371 FIT kits mailed out, 16,152 (75.6%) were returned, of which, 2694 (16.7%) had at least one FIT value ≥100ng/mL. The highest positive FIT values ranged from 100 to 54,017, with a mean of 942.3, 25(th) percentile of 145, 50(th) percentile of 260, and 75(th) percentile of 576. At the time of analysis, 1831 participants had been further evaluated by colonoscopy. Of those who had a colonoscopy, 73 (4.0%) were found to have colorectal cancer and 1092 (59.6%) were found to have an adenoma. The positive predictive value for both adenomas and colorectal cancer increased with increasing FIT values and serial positive values. Those with two FIT values ≥5000ng/mL had the highest adenoma detection rate (100.0%) and highest rate of colorectal cancer (53.8%), which was significantly higher than those with one FIT value ≥100ng/mL (p-values 0.002 and ≤0.001, respectively). CONCLUSIONS: There is a limited amount of Canadian research evaluating ...