Gastrinoma and Zollinger–Ellison syndrome in canids: a literature review and a case in a Mexican gray wolf
Gastrinoma, an infrequent diagnosis in middle-aged dogs, occurs with nonspecific gastrointestinal morbidity. Laboratory tests can yield a presumptive diagnosis, but definitive diagnosis depends on histopathology and immunohistochemistry. We describe a malignant pancreatic gastrinoma with lymph node...
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ftpubmed:oai:pubmedcentral.nih.gov:6505925 2023-05-15T15:50:46+02:00 Gastrinoma and Zollinger–Ellison syndrome in canids: a literature review and a case in a Mexican gray wolf Struthers, Jason D. Robl, Nick Wong, Valerie M. Kiupel, Matti 2018-06-02 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6505925/ http://www.ncbi.nlm.nih.gov/pubmed/29860931 https://doi.org/10.1177/1040638718779638 en eng SAGE Publications http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6505925/ http://www.ncbi.nlm.nih.gov/pubmed/29860931 http://dx.doi.org/10.1177/1040638718779638 © 2018 The Author(s) Brief Communications Text 2018 ftpubmed https://doi.org/10.1177/1040638718779638 2019-06-09T00:11:13Z Gastrinoma, an infrequent diagnosis in middle-aged dogs, occurs with nonspecific gastrointestinal morbidity. Laboratory tests can yield a presumptive diagnosis, but definitive diagnosis depends on histopathology and immunohistochemistry. We describe a malignant pancreatic gastrinoma with lymph node metastases and corresponding Zollinger–Ellison syndrome in a Mexican gray wolf (Canis lupus baileyi) and review this endocrine neoplasm in domestic dogs. A 12-y-old, captive, male Mexican gray wolf developed inappetence and weight loss. Abdominal ultrasonography revealed a thickened duodenum and peritoneal effusion. Two duodenal perforations were noted on exploratory celiotomy and were repaired. Persisting clinical signs led to a second celiotomy that revealed a mesenteric mass, which was diagnosed histologically as a neuroendocrine carcinoma. During the following 16 mo, the wolf received a combination of H(2)-receptor antagonists, proton-pump inhibitors, gastroprotectants, and anti-emetics, but had recurrent episodes of anorexia, nausea, acid reflux, and remained underweight. Worsening clinical signs and weakness prompted euthanasia. The antemortem serum gastrin concentration of 414 ng/L (reference interval: 10–40 ng/L) corroborated hypergastrinemia. Autopsy revealed a mass expanding the right pancreatic limb; 3 parapancreatic mesenteric masses; duodenal ulcers; focal duodenal perforation with septic fibrinosuppurative peritonitis; chronic-active ulcerative esophagitis; and poor body condition. The pancreatic mass was diagnosed histologically as a neuroendocrine carcinoma and the parapancreatic masses as lymph node metastases. Immunohistochemistry of the pancreatic mass was positive for gastrin and negative for glucagon, insulin, pancreatic polypeptide, serotonin, somatostatin, and vasoactive intestinal peptide. Text Canis lupus gray wolf PubMed Central (PMC) Journal of Veterinary Diagnostic Investigation 30 4 584 588 |
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Brief Communications Struthers, Jason D. Robl, Nick Wong, Valerie M. Kiupel, Matti Gastrinoma and Zollinger–Ellison syndrome in canids: a literature review and a case in a Mexican gray wolf |
topic_facet |
Brief Communications |
description |
Gastrinoma, an infrequent diagnosis in middle-aged dogs, occurs with nonspecific gastrointestinal morbidity. Laboratory tests can yield a presumptive diagnosis, but definitive diagnosis depends on histopathology and immunohistochemistry. We describe a malignant pancreatic gastrinoma with lymph node metastases and corresponding Zollinger–Ellison syndrome in a Mexican gray wolf (Canis lupus baileyi) and review this endocrine neoplasm in domestic dogs. A 12-y-old, captive, male Mexican gray wolf developed inappetence and weight loss. Abdominal ultrasonography revealed a thickened duodenum and peritoneal effusion. Two duodenal perforations were noted on exploratory celiotomy and were repaired. Persisting clinical signs led to a second celiotomy that revealed a mesenteric mass, which was diagnosed histologically as a neuroendocrine carcinoma. During the following 16 mo, the wolf received a combination of H(2)-receptor antagonists, proton-pump inhibitors, gastroprotectants, and anti-emetics, but had recurrent episodes of anorexia, nausea, acid reflux, and remained underweight. Worsening clinical signs and weakness prompted euthanasia. The antemortem serum gastrin concentration of 414 ng/L (reference interval: 10–40 ng/L) corroborated hypergastrinemia. Autopsy revealed a mass expanding the right pancreatic limb; 3 parapancreatic mesenteric masses; duodenal ulcers; focal duodenal perforation with septic fibrinosuppurative peritonitis; chronic-active ulcerative esophagitis; and poor body condition. The pancreatic mass was diagnosed histologically as a neuroendocrine carcinoma and the parapancreatic masses as lymph node metastases. Immunohistochemistry of the pancreatic mass was positive for gastrin and negative for glucagon, insulin, pancreatic polypeptide, serotonin, somatostatin, and vasoactive intestinal peptide. |
format |
Text |
author |
Struthers, Jason D. Robl, Nick Wong, Valerie M. Kiupel, Matti |
author_facet |
Struthers, Jason D. Robl, Nick Wong, Valerie M. Kiupel, Matti |
author_sort |
Struthers, Jason D. |
title |
Gastrinoma and Zollinger–Ellison syndrome in canids: a literature review and a case in a Mexican gray wolf |
title_short |
Gastrinoma and Zollinger–Ellison syndrome in canids: a literature review and a case in a Mexican gray wolf |
title_full |
Gastrinoma and Zollinger–Ellison syndrome in canids: a literature review and a case in a Mexican gray wolf |
title_fullStr |
Gastrinoma and Zollinger–Ellison syndrome in canids: a literature review and a case in a Mexican gray wolf |
title_full_unstemmed |
Gastrinoma and Zollinger–Ellison syndrome in canids: a literature review and a case in a Mexican gray wolf |
title_sort |
gastrinoma and zollinger–ellison syndrome in canids: a literature review and a case in a mexican gray wolf |
publisher |
SAGE Publications |
publishDate |
2018 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6505925/ http://www.ncbi.nlm.nih.gov/pubmed/29860931 https://doi.org/10.1177/1040638718779638 |
genre |
Canis lupus gray wolf |
genre_facet |
Canis lupus gray wolf |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6505925/ http://www.ncbi.nlm.nih.gov/pubmed/29860931 http://dx.doi.org/10.1177/1040638718779638 |
op_rights |
© 2018 The Author(s) |
op_doi |
https://doi.org/10.1177/1040638718779638 |
container_title |
Journal of Veterinary Diagnostic Investigation |
container_volume |
30 |
container_issue |
4 |
container_start_page |
584 |
op_container_end_page |
588 |
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1766385790315659264 |