Shifting Global Exposures to Poly- and Perfluoroalkyl Substances (PFASs) Evident in Longitudinal Birth Cohorts from a Seafood Consuming Population
Rapid declines in legacy poly- and perfluoroalkyl substances (PFASs) have been reported in human populations globally following changes in production since 2000. However, changes in exposure sources are not well understood. Here, we report serum concentrations of 19 PFASs (∑(19) PFAS) measured in ch...
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ftpubmed:oai:pubmedcentral.nih.gov:6438388 2023-05-15T16:10:54+02:00 Shifting Global Exposures to Poly- and Perfluoroalkyl Substances (PFASs) Evident in Longitudinal Birth Cohorts from a Seafood Consuming Population Dassuncao, Clifton Hu, Xindi C. Nielsen, Flemming Weihe, Pál Grandjean, Philippe Sunderland, Elsie M. 2018-03-12 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438388/ http://www.ncbi.nlm.nih.gov/pubmed/29516726 https://doi.org/10.1021/acs.est.7b06044 en eng http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438388/ http://www.ncbi.nlm.nih.gov/pubmed/29516726 http://dx.doi.org/10.1021/acs.est.7b06044 Article Text 2018 ftpubmed https://doi.org/10.1021/acs.est.7b06044 2019-03-31T01:22:32Z Rapid declines in legacy poly- and perfluoroalkyl substances (PFASs) have been reported in human populations globally following changes in production since 2000. However, changes in exposure sources are not well understood. Here, we report serum concentrations of 19 PFASs (∑(19) PFAS) measured in children between 1993 and 2012 from a North Atlantic fishing community (Faroe Islands). Median ∑(19) PFAS concentrations in children (ages 5 to 13 years) peaked in 2000 (47.7 ng mL(−1)) and declined significantly by 14.4% yr(−1) until 2012. Principal component analysis (PCA) identified two groups of PFASs that likely reflect exposures from diverse consumer products and a third group that consisted of perfluorocarboxylic acids (PFCAs) with nine or more carbons (C≥9). These C≥9 PFASs are strongly associated with mercury in children’s hair, a well-established proxy for seafood consumption, especially perfluoroundecanoic acid (PFUnDA, r = 0.72). Toxicokinetic modeling shows PFAS exposures from seafood have become increasingly important (53% of perfluorooctane sulfonate: PFOS in 2012), despite a decline in whale consumption in recent years. We infer that even in a major seafood consuming population, declines in legacy PFAS exposure after 2000 were achieved by the rapid phase out of PFOS and its precursors in consumer products. These results emphasize the importance of better understanding exposures to replacement PFASs in these sources. Text Faroe Islands North Atlantic PubMed Central (PMC) Faroe Islands Environmental Science & Technology 52 6 3738 3747 |
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Article Dassuncao, Clifton Hu, Xindi C. Nielsen, Flemming Weihe, Pál Grandjean, Philippe Sunderland, Elsie M. Shifting Global Exposures to Poly- and Perfluoroalkyl Substances (PFASs) Evident in Longitudinal Birth Cohorts from a Seafood Consuming Population |
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Article |
description |
Rapid declines in legacy poly- and perfluoroalkyl substances (PFASs) have been reported in human populations globally following changes in production since 2000. However, changes in exposure sources are not well understood. Here, we report serum concentrations of 19 PFASs (∑(19) PFAS) measured in children between 1993 and 2012 from a North Atlantic fishing community (Faroe Islands). Median ∑(19) PFAS concentrations in children (ages 5 to 13 years) peaked in 2000 (47.7 ng mL(−1)) and declined significantly by 14.4% yr(−1) until 2012. Principal component analysis (PCA) identified two groups of PFASs that likely reflect exposures from diverse consumer products and a third group that consisted of perfluorocarboxylic acids (PFCAs) with nine or more carbons (C≥9). These C≥9 PFASs are strongly associated with mercury in children’s hair, a well-established proxy for seafood consumption, especially perfluoroundecanoic acid (PFUnDA, r = 0.72). Toxicokinetic modeling shows PFAS exposures from seafood have become increasingly important (53% of perfluorooctane sulfonate: PFOS in 2012), despite a decline in whale consumption in recent years. We infer that even in a major seafood consuming population, declines in legacy PFAS exposure after 2000 were achieved by the rapid phase out of PFOS and its precursors in consumer products. These results emphasize the importance of better understanding exposures to replacement PFASs in these sources. |
format |
Text |
author |
Dassuncao, Clifton Hu, Xindi C. Nielsen, Flemming Weihe, Pál Grandjean, Philippe Sunderland, Elsie M. |
author_facet |
Dassuncao, Clifton Hu, Xindi C. Nielsen, Flemming Weihe, Pál Grandjean, Philippe Sunderland, Elsie M. |
author_sort |
Dassuncao, Clifton |
title |
Shifting Global Exposures to Poly- and Perfluoroalkyl Substances (PFASs) Evident in Longitudinal Birth Cohorts from a Seafood Consuming Population |
title_short |
Shifting Global Exposures to Poly- and Perfluoroalkyl Substances (PFASs) Evident in Longitudinal Birth Cohorts from a Seafood Consuming Population |
title_full |
Shifting Global Exposures to Poly- and Perfluoroalkyl Substances (PFASs) Evident in Longitudinal Birth Cohorts from a Seafood Consuming Population |
title_fullStr |
Shifting Global Exposures to Poly- and Perfluoroalkyl Substances (PFASs) Evident in Longitudinal Birth Cohorts from a Seafood Consuming Population |
title_full_unstemmed |
Shifting Global Exposures to Poly- and Perfluoroalkyl Substances (PFASs) Evident in Longitudinal Birth Cohorts from a Seafood Consuming Population |
title_sort |
shifting global exposures to poly- and perfluoroalkyl substances (pfass) evident in longitudinal birth cohorts from a seafood consuming population |
publishDate |
2018 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438388/ http://www.ncbi.nlm.nih.gov/pubmed/29516726 https://doi.org/10.1021/acs.est.7b06044 |
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Faroe Islands |
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Faroe Islands |
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Faroe Islands North Atlantic |
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Faroe Islands North Atlantic |
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438388/ http://www.ncbi.nlm.nih.gov/pubmed/29516726 http://dx.doi.org/10.1021/acs.est.7b06044 |
op_doi |
https://doi.org/10.1021/acs.est.7b06044 |
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Environmental Science & Technology |
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52 |
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6 |
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3738 |
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3747 |
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1765996034754871296 |