The Association of Body Size, Shape and Composition with Vertebral Size in Midlife – The Northern Finland Birth Cohort 1966 Study
Small vertebral size increases the risk of osteoporotic vertebral fractures. Obese individuals have larger vertebral size and potentially lower fracture risk than lean individuals, but scarce data exist on the association between vertebral size and anthropometric measures beyond height, weight, and...
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ftpubmed:oai:pubmedcentral.nih.gov:6408584 2023-05-15T17:42:17+02:00 The Association of Body Size, Shape and Composition with Vertebral Size in Midlife – The Northern Finland Birth Cohort 1966 Study Oura, Petteri Nurkkala, Marjukka Auvinen, Juha Niinimäki, Jaakko Karppinen, Jaro Junno, Juho-Antti 2019-03-08 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408584/ http://www.ncbi.nlm.nih.gov/pubmed/30850701 https://doi.org/10.1038/s41598-019-40880-4 en eng Nature Publishing Group UK http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408584/ http://www.ncbi.nlm.nih.gov/pubmed/30850701 http://dx.doi.org/10.1038/s41598-019-40880-4 © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. CC-BY Article Text 2019 ftpubmed https://doi.org/10.1038/s41598-019-40880-4 2019-03-17T01:20:57Z Small vertebral size increases the risk of osteoporotic vertebral fractures. Obese individuals have larger vertebral size and potentially lower fracture risk than lean individuals, but scarce data exist on the association between vertebral size and anthropometric measures beyond height, weight, and body mass index (BMI). Here, we evaluated several anthropometric measures (height, weight, BMI, waist circumference, hip circumference, waist-to-hip ratio [WHR], waist-to-height ratio [WHtR], fat mass [FM], lean body mass [LBM], percentage FM [%FM], percentage LBM [%LBM]) as predictors of vertebral cross-sectional area (CSA). We used a representative sample from the Northern Finland Birth Cohort 1966 (n = 1087), with anthropometric measurements from the ages of 31 and 46, bioimpedance analysis from the age of 46, and lumbar magnetic resonance imaging from the age of 46 years. In our data, height and LBM correlated most strongly with vertebral CSA among both sexes (0.469 ≤ r ≤ 0.514), while WHR, WHtR, %FM, and %LBM had the weakest correlations with vertebral CSA (|r| ≤ 0.114). We conclude that height and LBM have the highest, yet only moderate correlations with vertebral size. High absolute LBM, rather than FM or abdominal mass accumulation, correlates with large vertebral size and thus potentially also with lower osteoporotic vertebral fracture risk. Text Northern Finland PubMed Central (PMC) Scientific Reports 9 1 |
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Article Oura, Petteri Nurkkala, Marjukka Auvinen, Juha Niinimäki, Jaakko Karppinen, Jaro Junno, Juho-Antti The Association of Body Size, Shape and Composition with Vertebral Size in Midlife – The Northern Finland Birth Cohort 1966 Study |
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Small vertebral size increases the risk of osteoporotic vertebral fractures. Obese individuals have larger vertebral size and potentially lower fracture risk than lean individuals, but scarce data exist on the association between vertebral size and anthropometric measures beyond height, weight, and body mass index (BMI). Here, we evaluated several anthropometric measures (height, weight, BMI, waist circumference, hip circumference, waist-to-hip ratio [WHR], waist-to-height ratio [WHtR], fat mass [FM], lean body mass [LBM], percentage FM [%FM], percentage LBM [%LBM]) as predictors of vertebral cross-sectional area (CSA). We used a representative sample from the Northern Finland Birth Cohort 1966 (n = 1087), with anthropometric measurements from the ages of 31 and 46, bioimpedance analysis from the age of 46, and lumbar magnetic resonance imaging from the age of 46 years. In our data, height and LBM correlated most strongly with vertebral CSA among both sexes (0.469 ≤ r ≤ 0.514), while WHR, WHtR, %FM, and %LBM had the weakest correlations with vertebral CSA (|r| ≤ 0.114). We conclude that height and LBM have the highest, yet only moderate correlations with vertebral size. High absolute LBM, rather than FM or abdominal mass accumulation, correlates with large vertebral size and thus potentially also with lower osteoporotic vertebral fracture risk. |
format |
Text |
author |
Oura, Petteri Nurkkala, Marjukka Auvinen, Juha Niinimäki, Jaakko Karppinen, Jaro Junno, Juho-Antti |
author_facet |
Oura, Petteri Nurkkala, Marjukka Auvinen, Juha Niinimäki, Jaakko Karppinen, Jaro Junno, Juho-Antti |
author_sort |
Oura, Petteri |
title |
The Association of Body Size, Shape and Composition with Vertebral Size in Midlife – The Northern Finland Birth Cohort 1966 Study |
title_short |
The Association of Body Size, Shape and Composition with Vertebral Size in Midlife – The Northern Finland Birth Cohort 1966 Study |
title_full |
The Association of Body Size, Shape and Composition with Vertebral Size in Midlife – The Northern Finland Birth Cohort 1966 Study |
title_fullStr |
The Association of Body Size, Shape and Composition with Vertebral Size in Midlife – The Northern Finland Birth Cohort 1966 Study |
title_full_unstemmed |
The Association of Body Size, Shape and Composition with Vertebral Size in Midlife – The Northern Finland Birth Cohort 1966 Study |
title_sort |
association of body size, shape and composition with vertebral size in midlife – the northern finland birth cohort 1966 study |
publisher |
Nature Publishing Group UK |
publishDate |
2019 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408584/ http://www.ncbi.nlm.nih.gov/pubmed/30850701 https://doi.org/10.1038/s41598-019-40880-4 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408584/ http://www.ncbi.nlm.nih.gov/pubmed/30850701 http://dx.doi.org/10.1038/s41598-019-40880-4 |
op_rights |
© The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
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CC-BY |
op_doi |
https://doi.org/10.1038/s41598-019-40880-4 |
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Scientific Reports |
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