Individual differences in EPA and DHA content of Atlantic salmon are associated with gene expression of key metabolic processes
The aim of this study was to explore how individual differences in content of the omega-3 fatty acids EPA and DHA in skeletal muscle of slaughter-sized Atlantic salmon, are associated with expression of genes involved in key metabolic processes. All experimental fish were fed the same diet throughou...
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ftpubmed:oai:pubmedcentral.nih.gov:6405848 2023-05-15T15:31:23+02:00 Individual differences in EPA and DHA content of Atlantic salmon are associated with gene expression of key metabolic processes Horn, Siri S. Sonesson, Anna K. Krasnov, Aleksei Moghadam, Hooman Hillestad, Borghild Meuwissen, Theo H. E. Ruyter, Bente 2019-03-07 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405848/ http://www.ncbi.nlm.nih.gov/pubmed/30846825 https://doi.org/10.1038/s41598-019-40391-2 en eng Nature Publishing Group UK http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405848/ http://www.ncbi.nlm.nih.gov/pubmed/30846825 http://dx.doi.org/10.1038/s41598-019-40391-2 © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. CC-BY Article Text 2019 ftpubmed https://doi.org/10.1038/s41598-019-40391-2 2019-03-17T01:19:05Z The aim of this study was to explore how individual differences in content of the omega-3 fatty acids EPA and DHA in skeletal muscle of slaughter-sized Atlantic salmon, are associated with expression of genes involved in key metabolic processes. All experimental fish were fed the same diet throughout life and fasted for 14 days prior to slaughter. Still, there were relatively large individual variations in EPA and DHA content of skeletal muscle. Higher DHA content was concurrent with increased expression of genes of the glycolytic pathway and the production of pyruvate and lactate, whereas EPA was associated with increased expression of pentose phosphate pathway and glycogen breakdown genes. Furthermore, EPA, but not DHA, was associated with expression of genes involved in insulin signaling. Expression of genes specific for skeletal muscle function were positively associated with both EPA and DHA. EPA and DHA were also associated with expression of genes related to eicosanoid and resolvin production. EPA was negatively associated with expression of genes involved in lipid catabolism. Thus, a possible reason why some individuals have a higher level of EPA in the skeletal muscle is that they deposit - rather than oxidize - EPA for energy. Text Atlantic salmon PubMed Central (PMC) Slaughter ENVELOPE(-85.633,-85.633,-78.617,-78.617) Scientific Reports 9 1 |
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Article Horn, Siri S. Sonesson, Anna K. Krasnov, Aleksei Moghadam, Hooman Hillestad, Borghild Meuwissen, Theo H. E. Ruyter, Bente Individual differences in EPA and DHA content of Atlantic salmon are associated with gene expression of key metabolic processes |
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The aim of this study was to explore how individual differences in content of the omega-3 fatty acids EPA and DHA in skeletal muscle of slaughter-sized Atlantic salmon, are associated with expression of genes involved in key metabolic processes. All experimental fish were fed the same diet throughout life and fasted for 14 days prior to slaughter. Still, there were relatively large individual variations in EPA and DHA content of skeletal muscle. Higher DHA content was concurrent with increased expression of genes of the glycolytic pathway and the production of pyruvate and lactate, whereas EPA was associated with increased expression of pentose phosphate pathway and glycogen breakdown genes. Furthermore, EPA, but not DHA, was associated with expression of genes involved in insulin signaling. Expression of genes specific for skeletal muscle function were positively associated with both EPA and DHA. EPA and DHA were also associated with expression of genes related to eicosanoid and resolvin production. EPA was negatively associated with expression of genes involved in lipid catabolism. Thus, a possible reason why some individuals have a higher level of EPA in the skeletal muscle is that they deposit - rather than oxidize - EPA for energy. |
format |
Text |
author |
Horn, Siri S. Sonesson, Anna K. Krasnov, Aleksei Moghadam, Hooman Hillestad, Borghild Meuwissen, Theo H. E. Ruyter, Bente |
author_facet |
Horn, Siri S. Sonesson, Anna K. Krasnov, Aleksei Moghadam, Hooman Hillestad, Borghild Meuwissen, Theo H. E. Ruyter, Bente |
author_sort |
Horn, Siri S. |
title |
Individual differences in EPA and DHA content of Atlantic salmon are associated with gene expression of key metabolic processes |
title_short |
Individual differences in EPA and DHA content of Atlantic salmon are associated with gene expression of key metabolic processes |
title_full |
Individual differences in EPA and DHA content of Atlantic salmon are associated with gene expression of key metabolic processes |
title_fullStr |
Individual differences in EPA and DHA content of Atlantic salmon are associated with gene expression of key metabolic processes |
title_full_unstemmed |
Individual differences in EPA and DHA content of Atlantic salmon are associated with gene expression of key metabolic processes |
title_sort |
individual differences in epa and dha content of atlantic salmon are associated with gene expression of key metabolic processes |
publisher |
Nature Publishing Group UK |
publishDate |
2019 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405848/ http://www.ncbi.nlm.nih.gov/pubmed/30846825 https://doi.org/10.1038/s41598-019-40391-2 |
long_lat |
ENVELOPE(-85.633,-85.633,-78.617,-78.617) |
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Slaughter |
geographic_facet |
Slaughter |
genre |
Atlantic salmon |
genre_facet |
Atlantic salmon |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405848/ http://www.ncbi.nlm.nih.gov/pubmed/30846825 http://dx.doi.org/10.1038/s41598-019-40391-2 |
op_rights |
© The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
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CC-BY |
op_doi |
https://doi.org/10.1038/s41598-019-40391-2 |
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Scientific Reports |
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