Baloxavir marboxil: un potente inhibidor de la endonucleasa cap-dependiente de los virus gripales
Baloxavir marboxil (5-hydroxy-4-pyridone-3-carboxyl acid) is a new antiviral drug with special efficacy on influenza viruses that acts by inhibiting the cap-dependent endonuclease required for its replication. It is the first representative of the so-called inhibitors of influenza-like PB2. It has s...
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ftpubmed:oai:pubmedcentral.nih.gov:6372968 2023-05-15T15:34:27+02:00 Baloxavir marboxil: un potente inhibidor de la endonucleasa cap-dependiente de los virus gripales Reina, Jordi Reina, Nuria 2019-02-08 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372968/ http://www.ncbi.nlm.nih.gov/pubmed/30676002 en eng Sociedad Española de Quimioterapia http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372968/ http://www.ncbi.nlm.nih.gov/pubmed/30676002 © The Author 2019 https://creativecommons.org/licenses/by-nc/4.0/ The article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/) CC-BY-NC Revisión Text 2019 ftpubmed 2019-03-10T01:09:56Z Baloxavir marboxil (5-hydroxy-4-pyridone-3-carboxyl acid) is a new antiviral drug with special efficacy on influenza viruses that acts by inhibiting the cap-dependent endonuclease required for its replication. It is the first representative of the so-called inhibitors of influenza-like PB2. It has shown efficacy against influenza viruses A and B and most strains of animal origin (avian flu). Clinical trials conducted in healthy patients between 12 and 64 years without pathologies and not hospitalized (mild flu) have shown a reduction in the duration of symptoms similar to that obtained by oseltamivir. However, baloxavir is a much more potent inhibitor of viral replication than this drug. It has been shown as a safe and well tolerated drug. A single dose of 40-80 mg is administered the first 48 hours after onset of symptoms. In these trials, strains with moderate sensitivity (PA / I38T mutants) were detected in 2.2% of influenza A (H1N1) pdm09 and in 9.7% of influenza A (H3N2). Although these data could be a good drug to treat mild or moderate influenza, requiring trials in severe influenza and patients with chronic diseases to establish their true clinical utility. Text Avian flu PubMed Central (PMC) |
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Revisión Reina, Jordi Reina, Nuria Baloxavir marboxil: un potente inhibidor de la endonucleasa cap-dependiente de los virus gripales |
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Revisión |
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Baloxavir marboxil (5-hydroxy-4-pyridone-3-carboxyl acid) is a new antiviral drug with special efficacy on influenza viruses that acts by inhibiting the cap-dependent endonuclease required for its replication. It is the first representative of the so-called inhibitors of influenza-like PB2. It has shown efficacy against influenza viruses A and B and most strains of animal origin (avian flu). Clinical trials conducted in healthy patients between 12 and 64 years without pathologies and not hospitalized (mild flu) have shown a reduction in the duration of symptoms similar to that obtained by oseltamivir. However, baloxavir is a much more potent inhibitor of viral replication than this drug. It has been shown as a safe and well tolerated drug. A single dose of 40-80 mg is administered the first 48 hours after onset of symptoms. In these trials, strains with moderate sensitivity (PA / I38T mutants) were detected in 2.2% of influenza A (H1N1) pdm09 and in 9.7% of influenza A (H3N2). Although these data could be a good drug to treat mild or moderate influenza, requiring trials in severe influenza and patients with chronic diseases to establish their true clinical utility. |
format |
Text |
author |
Reina, Jordi Reina, Nuria |
author_facet |
Reina, Jordi Reina, Nuria |
author_sort |
Reina, Jordi |
title |
Baloxavir marboxil: un potente inhibidor de la endonucleasa cap-dependiente de los virus gripales |
title_short |
Baloxavir marboxil: un potente inhibidor de la endonucleasa cap-dependiente de los virus gripales |
title_full |
Baloxavir marboxil: un potente inhibidor de la endonucleasa cap-dependiente de los virus gripales |
title_fullStr |
Baloxavir marboxil: un potente inhibidor de la endonucleasa cap-dependiente de los virus gripales |
title_full_unstemmed |
Baloxavir marboxil: un potente inhibidor de la endonucleasa cap-dependiente de los virus gripales |
title_sort |
baloxavir marboxil: un potente inhibidor de la endonucleasa cap-dependiente de los virus gripales |
publisher |
Sociedad Española de Quimioterapia |
publishDate |
2019 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372968/ http://www.ncbi.nlm.nih.gov/pubmed/30676002 |
genre |
Avian flu |
genre_facet |
Avian flu |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372968/ http://www.ncbi.nlm.nih.gov/pubmed/30676002 |
op_rights |
© The Author 2019 https://creativecommons.org/licenses/by-nc/4.0/ The article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/) |
op_rightsnorm |
CC-BY-NC |
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