The genomics of major psychiatric disorders in a large pedigree from Northern Sweden

We searched for genetic causes of major psychiatric disorders (bipolar disorder, schizoaffective disorder, and schizophrenia) in a large, densely affected pedigree from Northern Sweden that originated with three pairs of founders born around 1650. We applied a systematic genomic approach to the pedi...

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Published in:Translational Psychiatry
Main Authors: Szatkiewicz, Jin, Crowley, James J., Adolfsson, Annelie Nordin, Åberg, Karolina A., Alaerts, Maaike, Genovese, Giulio, McCarroll, Steven, Del-Favero, Jurgen, Adolfsson, Rolf, Sullivan, Patrick F.
Format: Text
Language:English
Published: Nature Publishing Group UK 2019
Subjects:
Article
Northern Sweden
Online Access:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362018/
http://www.ncbi.nlm.nih.gov/pubmed/30718465
https://doi.org/10.1038/s41398-019-0414-9
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spelling ftpubmed:oai:pubmedcentral.nih.gov:6362018 2023-05-15T17:44:16+02:00 The genomics of major psychiatric disorders in a large pedigree from Northern Sweden Szatkiewicz, Jin Crowley, James J. Adolfsson, Annelie Nordin Åberg, Karolina A. Alaerts, Maaike Genovese, Giulio McCarroll, Steven Del-Favero, Jurgen Adolfsson, Rolf Sullivan, Patrick F. 2019-02-04 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362018/ http://www.ncbi.nlm.nih.gov/pubmed/30718465 https://doi.org/10.1038/s41398-019-0414-9 en eng Nature Publishing Group UK http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362018/ http://www.ncbi.nlm.nih.gov/pubmed/30718465 http://dx.doi.org/10.1038/s41398-019-0414-9 © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. CC-BY Article Text 2019 ftpubmed https://doi.org/10.1038/s41398-019-0414-9 2019-02-10T01:43:08Z We searched for genetic causes of major psychiatric disorders (bipolar disorder, schizoaffective disorder, and schizophrenia) in a large, densely affected pedigree from Northern Sweden that originated with three pairs of founders born around 1650. We applied a systematic genomic approach to the pedigree via karyotyping (N = 9), genome-wide SNP arrays (N = 418), whole-exome sequencing (N = 26), and whole-genome sequencing (N = 10). Comprehensive analysis did not identify plausible variants of strong effect. Rather, pedigree cases had significantly higher genetic risk scores compared to pedigree and community controls. Text Northern Sweden PubMed Central (PMC) Translational Psychiatry 9 1
institution Open Polar
collection PubMed Central (PMC)
op_collection_id ftpubmed
language English
topic Article
spellingShingle Article
Szatkiewicz, Jin
Crowley, James J.
Adolfsson, Annelie Nordin
Åberg, Karolina A.
Alaerts, Maaike
Genovese, Giulio
McCarroll, Steven
Del-Favero, Jurgen
Adolfsson, Rolf
Sullivan, Patrick F.
The genomics of major psychiatric disorders in a large pedigree from Northern Sweden
topic_facet Article
description We searched for genetic causes of major psychiatric disorders (bipolar disorder, schizoaffective disorder, and schizophrenia) in a large, densely affected pedigree from Northern Sweden that originated with three pairs of founders born around 1650. We applied a systematic genomic approach to the pedigree via karyotyping (N = 9), genome-wide SNP arrays (N = 418), whole-exome sequencing (N = 26), and whole-genome sequencing (N = 10). Comprehensive analysis did not identify plausible variants of strong effect. Rather, pedigree cases had significantly higher genetic risk scores compared to pedigree and community controls.
format Text
author Szatkiewicz, Jin
Crowley, James J.
Adolfsson, Annelie Nordin
Åberg, Karolina A.
Alaerts, Maaike
Genovese, Giulio
McCarroll, Steven
Del-Favero, Jurgen
Adolfsson, Rolf
Sullivan, Patrick F.
author_facet Szatkiewicz, Jin
Crowley, James J.
Adolfsson, Annelie Nordin
Åberg, Karolina A.
Alaerts, Maaike
Genovese, Giulio
McCarroll, Steven
Del-Favero, Jurgen
Adolfsson, Rolf
Sullivan, Patrick F.
author_sort Szatkiewicz, Jin
title The genomics of major psychiatric disorders in a large pedigree from Northern Sweden
title_short The genomics of major psychiatric disorders in a large pedigree from Northern Sweden
title_full The genomics of major psychiatric disorders in a large pedigree from Northern Sweden
title_fullStr The genomics of major psychiatric disorders in a large pedigree from Northern Sweden
title_full_unstemmed The genomics of major psychiatric disorders in a large pedigree from Northern Sweden
title_sort genomics of major psychiatric disorders in a large pedigree from northern sweden
publisher Nature Publishing Group UK
publishDate 2019
url http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362018/
http://www.ncbi.nlm.nih.gov/pubmed/30718465
https://doi.org/10.1038/s41398-019-0414-9
genre Northern Sweden
genre_facet Northern Sweden
op_relation http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362018/
http://www.ncbi.nlm.nih.gov/pubmed/30718465
http://dx.doi.org/10.1038/s41398-019-0414-9
op_rights © The Author(s) 2019
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
op_rightsnorm CC-BY
op_doi https://doi.org/10.1038/s41398-019-0414-9
container_title Translational Psychiatry
container_volume 9
container_issue 1
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