Histology of colorectal adenocarcinoma with double somatic mismatch-repair mutations is indistinguishable from those caused by Lynch syndrome

• Published in: Human Pathology
• Main Authors: Hemminger, Jessica A., Pearlman, Rachel, Haraldsdottir, Sigurdis, Knight, Deborah, Jonasson, Jon Gunnlaugur, Pritchard, Colin C., Hampel, Heather, Frankel, Wendy L.
• Format: Text
• Language: English
• Published: 2018
• Subjects: Article; Lynch; Iceland
• Online Access: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296362/; http://www.ncbi.nlm.nih.gov/pubmed/29723603; https://doi.org/10.1016/j.humpath.2018.04.017

Lynch syndrome (LS) is the most common form of hereditary colon cancer. Germline mutations in the mismatch-repair (MMR) genes MLH1, MSH2 (EPCAM), MSH6, and PMS2, followed by a second hit to the remaining allele, lead to cancer development. Universal tumor screening for LS is routinely performed on c...