Paternal grandfather’s access to food predicts all-cause and cancer mortality in grandsons
Studies of animals and plants suggest that nutritional conditions in one generation may affect phenotypic characteristics in subsequent generations. A small number of human studies claim to show that pre-pubertal nutritional experience trigger a sex-specific transgenerational response along the male...
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ftpubmed:oai:pubmedcentral.nih.gov:6290014 2023-05-15T17:44:33+02:00 Paternal grandfather’s access to food predicts all-cause and cancer mortality in grandsons Vågerö, Denny Pinger, Pia R. Aronsson, Vanda van den Berg, Gerard J. 2018-12-11 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290014/ http://www.ncbi.nlm.nih.gov/pubmed/30538239 https://doi.org/10.1038/s41467-018-07617-9 en eng Nature Publishing Group UK http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290014/ http://www.ncbi.nlm.nih.gov/pubmed/30538239 http://dx.doi.org/10.1038/s41467-018-07617-9 © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. CC-BY Article Text 2018 ftpubmed https://doi.org/10.1038/s41467-018-07617-9 2018-12-16T01:36:00Z Studies of animals and plants suggest that nutritional conditions in one generation may affect phenotypic characteristics in subsequent generations. A small number of human studies claim to show that pre-pubertal nutritional experience trigger a sex-specific transgenerational response along the male line. A single historical dataset, the Överkalix cohorts in northern Sweden, is often quoted as evidence. To test this hypothesis on an almost 40 times larger dataset we collect harvest data during the pre-pubertal period of grandparents (G0, n = 9,039) to examine its potential association with mortality in children (G1, n = 7,280) and grandchildren (G2, n = 11,561) in the Uppsala Multigeneration Study. We find support for the main Överkalix finding: paternal grandfather’s food access in pre-puberty predicts his male, but not female, grandchildren’s all-cause mortality. In our study, cancer mortality contributes strongly to this pattern. We are unable to reproduce previous results for diabetes and cardiovascular mortality. Text Northern Sweden Överkalix PubMed Central (PMC) Överkalix ENVELOPE(22.843,22.843,66.327,66.327) Nature Communications 9 1 |
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Article Vågerö, Denny Pinger, Pia R. Aronsson, Vanda van den Berg, Gerard J. Paternal grandfather’s access to food predicts all-cause and cancer mortality in grandsons |
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Article |
description |
Studies of animals and plants suggest that nutritional conditions in one generation may affect phenotypic characteristics in subsequent generations. A small number of human studies claim to show that pre-pubertal nutritional experience trigger a sex-specific transgenerational response along the male line. A single historical dataset, the Överkalix cohorts in northern Sweden, is often quoted as evidence. To test this hypothesis on an almost 40 times larger dataset we collect harvest data during the pre-pubertal period of grandparents (G0, n = 9,039) to examine its potential association with mortality in children (G1, n = 7,280) and grandchildren (G2, n = 11,561) in the Uppsala Multigeneration Study. We find support for the main Överkalix finding: paternal grandfather’s food access in pre-puberty predicts his male, but not female, grandchildren’s all-cause mortality. In our study, cancer mortality contributes strongly to this pattern. We are unable to reproduce previous results for diabetes and cardiovascular mortality. |
format |
Text |
author |
Vågerö, Denny Pinger, Pia R. Aronsson, Vanda van den Berg, Gerard J. |
author_facet |
Vågerö, Denny Pinger, Pia R. Aronsson, Vanda van den Berg, Gerard J. |
author_sort |
Vågerö, Denny |
title |
Paternal grandfather’s access to food predicts all-cause and cancer mortality in grandsons |
title_short |
Paternal grandfather’s access to food predicts all-cause and cancer mortality in grandsons |
title_full |
Paternal grandfather’s access to food predicts all-cause and cancer mortality in grandsons |
title_fullStr |
Paternal grandfather’s access to food predicts all-cause and cancer mortality in grandsons |
title_full_unstemmed |
Paternal grandfather’s access to food predicts all-cause and cancer mortality in grandsons |
title_sort |
paternal grandfather’s access to food predicts all-cause and cancer mortality in grandsons |
publisher |
Nature Publishing Group UK |
publishDate |
2018 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290014/ http://www.ncbi.nlm.nih.gov/pubmed/30538239 https://doi.org/10.1038/s41467-018-07617-9 |
long_lat |
ENVELOPE(22.843,22.843,66.327,66.327) |
geographic |
Överkalix |
geographic_facet |
Överkalix |
genre |
Northern Sweden Överkalix |
genre_facet |
Northern Sweden Överkalix |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290014/ http://www.ncbi.nlm.nih.gov/pubmed/30538239 http://dx.doi.org/10.1038/s41467-018-07617-9 |
op_rights |
© The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1038/s41467-018-07617-9 |
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Nature Communications |
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9 |
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1 |
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1766146799293169664 |