The Antioxidant Response Induced by Lonicera caerulaea Berry Extracts in Animals Bearing Experimental Solid Tumors
Lonicera caerulea is a species of bush native to the Kamchatka Peninsula (Russian Far East) whose berries have been extensively studied due to their potential high antioxidant activity. The aim of our work was to investigate the in vivo effects of the antioxidant action of Lonicera caerulea berry ex...
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ftpubmed:oai:pubmedcentral.nih.gov:6245305 2023-05-15T16:59:04+02:00 The Antioxidant Response Induced by Lonicera caerulaea Berry Extracts in Animals Bearing Experimental Solid Tumors Gruia, Maria Iuliana Oprea, Eliza Gruia, Ion Negoita, Valentina Farcasanu, Ileana Cornelia 2008-05-27 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245305/ http://www.ncbi.nlm.nih.gov/pubmed/18560338 https://doi.org/10.3390/molecules13051195 en eng MDPI http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245305/ http://www.ncbi.nlm.nih.gov/pubmed/18560338 http://dx.doi.org/10.3390/molecules13051195 © 2008 by the authors. Licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). CC-BY Article Text 2008 ftpubmed https://doi.org/10.3390/molecules13051195 2018-12-02T01:56:12Z Lonicera caerulea is a species of bush native to the Kamchatka Peninsula (Russian Far East) whose berries have been extensively studied due to their potential high antioxidant activity. The aim of our work was to investigate the in vivo effects of the antioxidant action of Lonicera caerulea berry extracts on the dynamics of experimentally-induced tumors. Our data showed that aqueous Lonicera caerulaea extracts reduced the tumor volume when administered continuously during the tumor growth and development stages, but augmented the tumor growth when the administration of extracts started three weeks before tumor grafting. Prolonged administration of Lonicera caerulaea berry extracts induced the antioxidant defense mechanism in the tumor tissues, while surprisingly amplifying the peripheral oxidative stress. Text Kamchatka Kamchatka Peninsula PubMed Central (PMC) Kamchatka Peninsula ENVELOPE(160.000,160.000,56.000,56.000) Molecules 13 5 1195 1206 |
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Article Gruia, Maria Iuliana Oprea, Eliza Gruia, Ion Negoita, Valentina Farcasanu, Ileana Cornelia The Antioxidant Response Induced by Lonicera caerulaea Berry Extracts in Animals Bearing Experimental Solid Tumors |
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Lonicera caerulea is a species of bush native to the Kamchatka Peninsula (Russian Far East) whose berries have been extensively studied due to their potential high antioxidant activity. The aim of our work was to investigate the in vivo effects of the antioxidant action of Lonicera caerulea berry extracts on the dynamics of experimentally-induced tumors. Our data showed that aqueous Lonicera caerulaea extracts reduced the tumor volume when administered continuously during the tumor growth and development stages, but augmented the tumor growth when the administration of extracts started three weeks before tumor grafting. Prolonged administration of Lonicera caerulaea berry extracts induced the antioxidant defense mechanism in the tumor tissues, while surprisingly amplifying the peripheral oxidative stress. |
format |
Text |
author |
Gruia, Maria Iuliana Oprea, Eliza Gruia, Ion Negoita, Valentina Farcasanu, Ileana Cornelia |
author_facet |
Gruia, Maria Iuliana Oprea, Eliza Gruia, Ion Negoita, Valentina Farcasanu, Ileana Cornelia |
author_sort |
Gruia, Maria Iuliana |
title |
The Antioxidant Response Induced by Lonicera caerulaea Berry Extracts in Animals Bearing Experimental Solid Tumors |
title_short |
The Antioxidant Response Induced by Lonicera caerulaea Berry Extracts in Animals Bearing Experimental Solid Tumors |
title_full |
The Antioxidant Response Induced by Lonicera caerulaea Berry Extracts in Animals Bearing Experimental Solid Tumors |
title_fullStr |
The Antioxidant Response Induced by Lonicera caerulaea Berry Extracts in Animals Bearing Experimental Solid Tumors |
title_full_unstemmed |
The Antioxidant Response Induced by Lonicera caerulaea Berry Extracts in Animals Bearing Experimental Solid Tumors |
title_sort |
antioxidant response induced by lonicera caerulaea berry extracts in animals bearing experimental solid tumors |
publisher |
MDPI |
publishDate |
2008 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245305/ http://www.ncbi.nlm.nih.gov/pubmed/18560338 https://doi.org/10.3390/molecules13051195 |
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ENVELOPE(160.000,160.000,56.000,56.000) |
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Kamchatka Peninsula |
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Kamchatka Peninsula |
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Kamchatka Kamchatka Peninsula |
genre_facet |
Kamchatka Kamchatka Peninsula |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245305/ http://www.ncbi.nlm.nih.gov/pubmed/18560338 http://dx.doi.org/10.3390/molecules13051195 |
op_rights |
© 2008 by the authors. Licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
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https://doi.org/10.3390/molecules13051195 |
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1195 |
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