LONGEVITY MECHANISMS IN LONG-LIVED MAMMALS

• Published in: Innovation in Aging
• Main Authors: Gorbunova, V., Seluanov, A.
• Format: Text
• Language: English
• Published: Oxford University Press 2017
• Subjects: Abstracts; bowhead whale
• Online Access: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6241481/; https://doi.org/10.1093/geroni/igx004.035

Animals have evolved a dramatic diversity of aging rates. Even within mammals, lifespans differ over 50-fold from four years in a mouse to 211 years in a bowhead whale. This natural diversity of lifespan can be exploited to understand the mechanisms of longevity. With modern technological advances now available, it became possible to undertake comparative study of aging at molecular level. Our goal is to identify mechanisms that allow such exceptionally long-lived animals to live long and healthy lives and then use these mechanisms to benefit human health. I will discuss our recent progress in the studies of tumor suppressor mechanisms, and DNA repair in short and long-lived rodent species.