Screening for kidney disease in Indigenous Canadian children: The FINISHED screen, triage and treat program

• Published in: Paediatrics & Child Health
• Main Authors: Dart, Allison, Lavallee, Barry, Chartrand, Caroline, McLeod, Lorraine, Ferguson, Thomas W, Tangri, Navdeep, Gordon, Audrey, Blydt-Hansen, Tom, Rigatto, Claudio, Komenda, Paul
• Format: Text
• Language: English
• Published: Oxford University Press 2018
• Subjects: Online Only Original Articles; Canada; First Nations
• Online Access: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199631/; http://www.ncbi.nlm.nih.gov/pubmed/30374222; https://doi.org/10.1093/pch/pxy013

BACKGROUND: Indigenous populations are disproportionately affected by kidney failure at younger ages than other ethnic groups in Canada. As symptoms do not occur until disease is advanced, early kidney disease risk is often unrecognized. OBJECTIVES: We sought to evaluate the yield of community-based screening for early risk factors for kidney disease in youth from rural Indigenous communities in Canada. METHODS: The FINISHED project screened 11 rural First Nations communities in Manitoba, Canada after community and school engagement. The results for the 10- to 17-year olds are reported here. Body mass index (BMI), blood pressure, estimated glomerular filtration rate (eGFR), hemoglobin A1c’s (HbA1c) and urine albumin-to-creatinine ratios (ACR) were assessed. All children were triaged and referred to either primary or tertiary care, depending on risk. RESULTS: A total of 353 were screened (estimated 22.4% of population). The median age was 12 years (IQR 10 to 13), 55% were female and 55% were overweight or obese. Overall, 21.8% of children had at least one abnormality. Hypertension was identified in 5.4% and 11.9% had prehypertension. None of the children had an eGFR < 60 ml/min/1.73 m(2) however 10.5% had an ACR > 3 mg/mmol and 6.2% had an eGFR < 90 ml/min/1.73 m(2) suggestive of early kidney disease. Diabetes was identified in 1.4%, and 1.4% had HbA1c’s between 6.1% and 6.49%. CONCLUSIONS: Risk factors for chronic kidney disease are highly prevalent in rural Indigenous children. More research is required to confirm the persistence of these findings, and to evaluate the efficacy of screening children to prevent or delay progression to kidney failure.