Immune-suppression by OsHV-1 viral infection causes fatal bacteraemia in Pacific oysters
Infectious diseases are mostly explored using reductionist approaches despite repeated evidence showing them to be strongly influenced by numerous interacting host and environmental factors. Many diseases with a complex aetiology therefore remain misunderstood. By developing a holistic approach to t...
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Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182001/ http://www.ncbi.nlm.nih.gov/pubmed/30310074 https://doi.org/10.1038/s41467-018-06659-3 |
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ftpubmed:oai:pubmedcentral.nih.gov:6182001 2023-05-15T15:58:31+02:00 Immune-suppression by OsHV-1 viral infection causes fatal bacteraemia in Pacific oysters de Lorgeril, Julien Lucasson, Aude Petton, Bruno Toulza, Eve Montagnani, Caroline Clerissi, Camille Vidal-Dupiol, Jeremie Chaparro, Cristian Galinier, Richard Escoubas, Jean-Michel Haffner, Philippe Dégremont, Lionel Charrière, Guillaume M. Lafont, Maxime Delort, Abigaïl Vergnes, Agnès Chiarello, Marlène Faury, Nicole Rubio, Tristan Leroy, Marc A. Pérignon, Adeline Régler, Denis Morga, Benjamin Alunno-Bruscia, Marianne Boudry, Pierre Le Roux, Frédérique Destoumieux-Garzόn, Delphine Gueguen, Yannick Mitta, Guillaume 2018-10-11 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182001/ http://www.ncbi.nlm.nih.gov/pubmed/30310074 https://doi.org/10.1038/s41467-018-06659-3 en eng Nature Publishing Group UK http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182001/ http://www.ncbi.nlm.nih.gov/pubmed/30310074 http://dx.doi.org/10.1038/s41467-018-06659-3 © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. CC-BY Article Text 2018 ftpubmed https://doi.org/10.1038/s41467-018-06659-3 2018-10-21T00:23:40Z Infectious diseases are mostly explored using reductionist approaches despite repeated evidence showing them to be strongly influenced by numerous interacting host and environmental factors. Many diseases with a complex aetiology therefore remain misunderstood. By developing a holistic approach to tackle the complexity of interactions, we decipher the complex intra-host interactions underlying Pacific oyster mortality syndrome affecting juveniles of Crassostrea gigas, the main oyster species exploited worldwide. Using experimental infections reproducing the natural route of infection and combining thorough molecular analyses of oyster families with contrasted susceptibilities, we demonstrate that the disease is caused by multiple infection with an initial and necessary step of infection of oyster haemocytes by the Ostreid herpesvirus OsHV-1 µVar. Viral replication leads to the host entering an immune-compromised state, evolving towards subsequent bacteraemia by opportunistic bacteria. We propose the application of our integrative approach to decipher other multifactorial diseases that affect non-model species worldwide. Text Crassostrea gigas Pacific oyster PubMed Central (PMC) Pacific Nature Communications 9 1 |
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Article de Lorgeril, Julien Lucasson, Aude Petton, Bruno Toulza, Eve Montagnani, Caroline Clerissi, Camille Vidal-Dupiol, Jeremie Chaparro, Cristian Galinier, Richard Escoubas, Jean-Michel Haffner, Philippe Dégremont, Lionel Charrière, Guillaume M. Lafont, Maxime Delort, Abigaïl Vergnes, Agnès Chiarello, Marlène Faury, Nicole Rubio, Tristan Leroy, Marc A. Pérignon, Adeline Régler, Denis Morga, Benjamin Alunno-Bruscia, Marianne Boudry, Pierre Le Roux, Frédérique Destoumieux-Garzόn, Delphine Gueguen, Yannick Mitta, Guillaume Immune-suppression by OsHV-1 viral infection causes fatal bacteraemia in Pacific oysters |
topic_facet |
Article |
description |
Infectious diseases are mostly explored using reductionist approaches despite repeated evidence showing them to be strongly influenced by numerous interacting host and environmental factors. Many diseases with a complex aetiology therefore remain misunderstood. By developing a holistic approach to tackle the complexity of interactions, we decipher the complex intra-host interactions underlying Pacific oyster mortality syndrome affecting juveniles of Crassostrea gigas, the main oyster species exploited worldwide. Using experimental infections reproducing the natural route of infection and combining thorough molecular analyses of oyster families with contrasted susceptibilities, we demonstrate that the disease is caused by multiple infection with an initial and necessary step of infection of oyster haemocytes by the Ostreid herpesvirus OsHV-1 µVar. Viral replication leads to the host entering an immune-compromised state, evolving towards subsequent bacteraemia by opportunistic bacteria. We propose the application of our integrative approach to decipher other multifactorial diseases that affect non-model species worldwide. |
format |
Text |
author |
de Lorgeril, Julien Lucasson, Aude Petton, Bruno Toulza, Eve Montagnani, Caroline Clerissi, Camille Vidal-Dupiol, Jeremie Chaparro, Cristian Galinier, Richard Escoubas, Jean-Michel Haffner, Philippe Dégremont, Lionel Charrière, Guillaume M. Lafont, Maxime Delort, Abigaïl Vergnes, Agnès Chiarello, Marlène Faury, Nicole Rubio, Tristan Leroy, Marc A. Pérignon, Adeline Régler, Denis Morga, Benjamin Alunno-Bruscia, Marianne Boudry, Pierre Le Roux, Frédérique Destoumieux-Garzόn, Delphine Gueguen, Yannick Mitta, Guillaume |
author_facet |
de Lorgeril, Julien Lucasson, Aude Petton, Bruno Toulza, Eve Montagnani, Caroline Clerissi, Camille Vidal-Dupiol, Jeremie Chaparro, Cristian Galinier, Richard Escoubas, Jean-Michel Haffner, Philippe Dégremont, Lionel Charrière, Guillaume M. Lafont, Maxime Delort, Abigaïl Vergnes, Agnès Chiarello, Marlène Faury, Nicole Rubio, Tristan Leroy, Marc A. Pérignon, Adeline Régler, Denis Morga, Benjamin Alunno-Bruscia, Marianne Boudry, Pierre Le Roux, Frédérique Destoumieux-Garzόn, Delphine Gueguen, Yannick Mitta, Guillaume |
author_sort |
de Lorgeril, Julien |
title |
Immune-suppression by OsHV-1 viral infection causes fatal bacteraemia in Pacific oysters |
title_short |
Immune-suppression by OsHV-1 viral infection causes fatal bacteraemia in Pacific oysters |
title_full |
Immune-suppression by OsHV-1 viral infection causes fatal bacteraemia in Pacific oysters |
title_fullStr |
Immune-suppression by OsHV-1 viral infection causes fatal bacteraemia in Pacific oysters |
title_full_unstemmed |
Immune-suppression by OsHV-1 viral infection causes fatal bacteraemia in Pacific oysters |
title_sort |
immune-suppression by oshv-1 viral infection causes fatal bacteraemia in pacific oysters |
publisher |
Nature Publishing Group UK |
publishDate |
2018 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182001/ http://www.ncbi.nlm.nih.gov/pubmed/30310074 https://doi.org/10.1038/s41467-018-06659-3 |
geographic |
Pacific |
geographic_facet |
Pacific |
genre |
Crassostrea gigas Pacific oyster |
genre_facet |
Crassostrea gigas Pacific oyster |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182001/ http://www.ncbi.nlm.nih.gov/pubmed/30310074 http://dx.doi.org/10.1038/s41467-018-06659-3 |
op_rights |
© The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1038/s41467-018-06659-3 |
container_title |
Nature Communications |
container_volume |
9 |
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1 |
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1766394261772697600 |