Sesterterpenoid and Steroid Metabolites from a Deep-Water Alaska Sponge Inhibit Wnt/β-Catenin Signaling in Colon Cancer Cells
The Wnt/β-catenin signaling pathway is known to play critical roles in a wide range of cellular processes: cell proliferation, differentiation, migration and embryonic development. Importantly, dysregulation of this pathway is tightly associated with pathogenesis in most human cancers. Therefore, th...
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ftpubmed:oai:pubmedcentral.nih.gov:6164309 2023-05-15T18:48:44+02:00 Sesterterpenoid and Steroid Metabolites from a Deep-Water Alaska Sponge Inhibit Wnt/β-Catenin Signaling in Colon Cancer Cells Park, Hyun Bong Tuan, Nguyen Quoc Oh, Joonseok Son, Younglim Hamann, Mark T. Stone, Robert Kelly, Michelle Oh, Sangtaek Na, MinKyun 2018-08-27 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164309/ http://www.ncbi.nlm.nih.gov/pubmed/30150508 https://doi.org/10.3390/md16090297 en eng MDPI http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164309/ http://www.ncbi.nlm.nih.gov/pubmed/30150508 http://dx.doi.org/10.3390/md16090297 © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). CC-BY Article Text 2018 ftpubmed https://doi.org/10.3390/md16090297 2018-10-14T00:28:28Z The Wnt/β-catenin signaling pathway is known to play critical roles in a wide range of cellular processes: cell proliferation, differentiation, migration and embryonic development. Importantly, dysregulation of this pathway is tightly associated with pathogenesis in most human cancers. Therefore, the Wnt/β-catenin pathway has emerged as a promising target in anticancer drug screening programs. In the present study, we have isolated three previously unreported metabolites from an undescribed sponge, a species of Monanchora (Order Poecilosclerida, Family Crambidae), closely related to the northeastern Pacific species Monanchora pulchra, collected from deep waters off the Aleutian Islands of Alaska. Through an assortment of NMR, MS, ECD, computational chemical shifts calculation, and DP4, chemical structures of these metabolites have been characterized as spirocyclic ring-containing sesterterpenoid (1) and cholestane-type steroidal analogues (2 and 3). These compounds exhibited the inhibition of β-catenin response transcription (CRT) through the promotion of β-catenin degradation, which was in part implicated in the antiproliferative activity against two CRT-positive colon cancer cell lines. Text Alaska Aleutian Islands PubMed Central (PMC) Pacific Marine Drugs 16 9 297 |
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Article Park, Hyun Bong Tuan, Nguyen Quoc Oh, Joonseok Son, Younglim Hamann, Mark T. Stone, Robert Kelly, Michelle Oh, Sangtaek Na, MinKyun Sesterterpenoid and Steroid Metabolites from a Deep-Water Alaska Sponge Inhibit Wnt/β-Catenin Signaling in Colon Cancer Cells |
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The Wnt/β-catenin signaling pathway is known to play critical roles in a wide range of cellular processes: cell proliferation, differentiation, migration and embryonic development. Importantly, dysregulation of this pathway is tightly associated with pathogenesis in most human cancers. Therefore, the Wnt/β-catenin pathway has emerged as a promising target in anticancer drug screening programs. In the present study, we have isolated three previously unreported metabolites from an undescribed sponge, a species of Monanchora (Order Poecilosclerida, Family Crambidae), closely related to the northeastern Pacific species Monanchora pulchra, collected from deep waters off the Aleutian Islands of Alaska. Through an assortment of NMR, MS, ECD, computational chemical shifts calculation, and DP4, chemical structures of these metabolites have been characterized as spirocyclic ring-containing sesterterpenoid (1) and cholestane-type steroidal analogues (2 and 3). These compounds exhibited the inhibition of β-catenin response transcription (CRT) through the promotion of β-catenin degradation, which was in part implicated in the antiproliferative activity against two CRT-positive colon cancer cell lines. |
format |
Text |
author |
Park, Hyun Bong Tuan, Nguyen Quoc Oh, Joonseok Son, Younglim Hamann, Mark T. Stone, Robert Kelly, Michelle Oh, Sangtaek Na, MinKyun |
author_facet |
Park, Hyun Bong Tuan, Nguyen Quoc Oh, Joonseok Son, Younglim Hamann, Mark T. Stone, Robert Kelly, Michelle Oh, Sangtaek Na, MinKyun |
author_sort |
Park, Hyun Bong |
title |
Sesterterpenoid and Steroid Metabolites from a Deep-Water Alaska Sponge Inhibit Wnt/β-Catenin Signaling in Colon Cancer Cells |
title_short |
Sesterterpenoid and Steroid Metabolites from a Deep-Water Alaska Sponge Inhibit Wnt/β-Catenin Signaling in Colon Cancer Cells |
title_full |
Sesterterpenoid and Steroid Metabolites from a Deep-Water Alaska Sponge Inhibit Wnt/β-Catenin Signaling in Colon Cancer Cells |
title_fullStr |
Sesterterpenoid and Steroid Metabolites from a Deep-Water Alaska Sponge Inhibit Wnt/β-Catenin Signaling in Colon Cancer Cells |
title_full_unstemmed |
Sesterterpenoid and Steroid Metabolites from a Deep-Water Alaska Sponge Inhibit Wnt/β-Catenin Signaling in Colon Cancer Cells |
title_sort |
sesterterpenoid and steroid metabolites from a deep-water alaska sponge inhibit wnt/β-catenin signaling in colon cancer cells |
publisher |
MDPI |
publishDate |
2018 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164309/ http://www.ncbi.nlm.nih.gov/pubmed/30150508 https://doi.org/10.3390/md16090297 |
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Pacific |
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Pacific |
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Alaska Aleutian Islands |
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Alaska Aleutian Islands |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164309/ http://www.ncbi.nlm.nih.gov/pubmed/30150508 http://dx.doi.org/10.3390/md16090297 |
op_rights |
© 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
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CC-BY |
op_doi |
https://doi.org/10.3390/md16090297 |
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Marine Drugs |
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16 |
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297 |
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