Assessment of Cardiac Autonomic Function in Relation to Methylmercury Neurotoxicity
After the European Food Safety Authority reviewed reports of methylmercury and heart rate variability (HRV) in 2012, the panel concluded that, although some studies of cardiac autonomy suggested an autonomic effect of methylmercury, the results were inconsistent among studies and the implications fo...
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ftpubmed:oai:pubmedcentral.nih.gov:6161203 2023-05-15T16:10:56+02:00 Assessment of Cardiac Autonomic Function in Relation to Methylmercury Neurotoxicity Karita, Kanae Iwata, Toyoto Maeda, Eri Sakamoto, Mineshi Murata, Katsuyuki 2018-07-20 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161203/ http://www.ncbi.nlm.nih.gov/pubmed/30036985 https://doi.org/10.3390/toxics6030038 en eng MDPI http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161203/ http://www.ncbi.nlm.nih.gov/pubmed/30036985 http://dx.doi.org/10.3390/toxics6030038 © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). CC-BY Review Text 2018 ftpubmed https://doi.org/10.3390/toxics6030038 2018-10-07T00:37:36Z After the European Food Safety Authority reviewed reports of methylmercury and heart rate variability (HRV) in 2012, the panel concluded that, although some studies of cardiac autonomy suggested an autonomic effect of methylmercury, the results were inconsistent among studies and the implications for health were unclear. In this study, we reconsider this association by adding a perspective on the physiological context. Cardiovascular rhythmicity is usually studied within different frequency domains of HRV. Three spectral components are usually detected; in humans these are centered at <0.04 Hz, 0.15 Hz (LF), and 0.3 Hz (HF). LF and HF (sympathetic and parasympathetic activities, respectively) are evaluated in terms of frequency and power. By searching PubMed, we identified 13 studies examining the effect of methylmercury exposure on HRV in human populations in the Faroe Islands, the Seychelles and other countries. Considering both reduced HRV and sympathodominant state (i.e., lower HF, higher LF, or higher LF/HF ratio) as autonomic abnormality, eight of them showed the significant association with methylmercury exposure. Five studies failed to demonstrate any significant association. In conclusion, these data suggest that increased methylmercury exposure was consistently associated with autonomic abnormality, though the influence of methylmercury on HRV (e.g., LF) might differ for prenatal and postnatal exposures. The results with HRV should be included in the risk characterization of methylmercury. The HRV parameters calculated by frequency domain analysis appear to be more sensitive to methylmercury exposure than those by time domain analysis. Text Faroe Islands PubMed Central (PMC) Faroe Islands Toxics 6 3 38 |
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Review Karita, Kanae Iwata, Toyoto Maeda, Eri Sakamoto, Mineshi Murata, Katsuyuki Assessment of Cardiac Autonomic Function in Relation to Methylmercury Neurotoxicity |
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Review |
description |
After the European Food Safety Authority reviewed reports of methylmercury and heart rate variability (HRV) in 2012, the panel concluded that, although some studies of cardiac autonomy suggested an autonomic effect of methylmercury, the results were inconsistent among studies and the implications for health were unclear. In this study, we reconsider this association by adding a perspective on the physiological context. Cardiovascular rhythmicity is usually studied within different frequency domains of HRV. Three spectral components are usually detected; in humans these are centered at <0.04 Hz, 0.15 Hz (LF), and 0.3 Hz (HF). LF and HF (sympathetic and parasympathetic activities, respectively) are evaluated in terms of frequency and power. By searching PubMed, we identified 13 studies examining the effect of methylmercury exposure on HRV in human populations in the Faroe Islands, the Seychelles and other countries. Considering both reduced HRV and sympathodominant state (i.e., lower HF, higher LF, or higher LF/HF ratio) as autonomic abnormality, eight of them showed the significant association with methylmercury exposure. Five studies failed to demonstrate any significant association. In conclusion, these data suggest that increased methylmercury exposure was consistently associated with autonomic abnormality, though the influence of methylmercury on HRV (e.g., LF) might differ for prenatal and postnatal exposures. The results with HRV should be included in the risk characterization of methylmercury. The HRV parameters calculated by frequency domain analysis appear to be more sensitive to methylmercury exposure than those by time domain analysis. |
format |
Text |
author |
Karita, Kanae Iwata, Toyoto Maeda, Eri Sakamoto, Mineshi Murata, Katsuyuki |
author_facet |
Karita, Kanae Iwata, Toyoto Maeda, Eri Sakamoto, Mineshi Murata, Katsuyuki |
author_sort |
Karita, Kanae |
title |
Assessment of Cardiac Autonomic Function in Relation to Methylmercury Neurotoxicity |
title_short |
Assessment of Cardiac Autonomic Function in Relation to Methylmercury Neurotoxicity |
title_full |
Assessment of Cardiac Autonomic Function in Relation to Methylmercury Neurotoxicity |
title_fullStr |
Assessment of Cardiac Autonomic Function in Relation to Methylmercury Neurotoxicity |
title_full_unstemmed |
Assessment of Cardiac Autonomic Function in Relation to Methylmercury Neurotoxicity |
title_sort |
assessment of cardiac autonomic function in relation to methylmercury neurotoxicity |
publisher |
MDPI |
publishDate |
2018 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161203/ http://www.ncbi.nlm.nih.gov/pubmed/30036985 https://doi.org/10.3390/toxics6030038 |
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Faroe Islands |
geographic_facet |
Faroe Islands |
genre |
Faroe Islands |
genre_facet |
Faroe Islands |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161203/ http://www.ncbi.nlm.nih.gov/pubmed/30036985 http://dx.doi.org/10.3390/toxics6030038 |
op_rights |
© 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
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CC-BY |
op_doi |
https://doi.org/10.3390/toxics6030038 |
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Toxics |
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38 |
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