Anticancer Activity of Ramalin, a Secondary Metabolite from the Antarctic Lichen Ramalina terebrata, against Colorectal Cancer Cells
Colorectal cancer is a leading cause of death worldwide and occurs through the highly complex coordination of multiple cellular pathways, resulting in carcinogenesis. Recent studies have increasingly revealed that constituents of lichen extracts exhibit potent pharmaceutical activities, including an...
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ftpubmed:oai:pubmedcentral.nih.gov:6152360 2023-05-15T13:32:17+02:00 Anticancer Activity of Ramalin, a Secondary Metabolite from the Antarctic Lichen Ramalina terebrata, against Colorectal Cancer Cells Suh, Sung-Suk Kim, Tai Kyoung Kim, Jung Eun Hong, Ju-Mi Nguyen, Trang Thu Thi Han, Se Jong Youn, Ui Joung Yim, Joung Han Kim, Il-Chan 2017-08-17 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152360/ http://www.ncbi.nlm.nih.gov/pubmed/28817102 https://doi.org/10.3390/molecules22081361 en eng MDPI http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152360/ http://www.ncbi.nlm.nih.gov/pubmed/28817102 http://dx.doi.org/10.3390/molecules22081361 © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). CC-BY Article Text 2017 ftpubmed https://doi.org/10.3390/molecules22081361 2018-11-18T01:56:27Z Colorectal cancer is a leading cause of death worldwide and occurs through the highly complex coordination of multiple cellular pathways, resulting in carcinogenesis. Recent studies have increasingly revealed that constituents of lichen extracts exhibit potent pharmaceutical activities, including anticancer activity against various cancer cells, making them promising candidates for new anticancer therapeutic drugs. The main objective of this study was to evaluate the anticancer capacities of ramalin, a secondary metabolite from the Antarctic lichen Ramalina terebrata, in the human colorectal cancer cell line HCT116. In this study, ramalin displayed concentration-dependent anticancer activity against HCT116 cells, significantly suppressing proliferation and inducing apoptosis. Furthermore, ramalin induced cell cycle arrest in the gap 2/mitosis (G2/M) phase through the modulation of hallmark genes involved in the G2/M phase transition, such as tumour protein p53 (TP53), cyclin-dependent kinase inhibitor 1A (CDKN1A), cyclin-dependent kinase 1 (CDK1) and cyclin B1 (CCNB1). At both the transcriptional and translational level, ramalin caused a gradual increase in the expression of TP53 and its downstream gene CDKN1A, while decreasing the expression of CDK1 and CCNB1 in a concentration-dependent manner. In addition, ramalin significantly inhibited the migration and invasion of colorectal cancer cells in a concentration-dependent manner. Taken together, these data suggest that ramalin may be a therapeutic candidate for the targeted therapy of colorectal cancer. Text Antarc* Antarctic PubMed Central (PMC) Antarctic The Antarctic Molecules 22 8 1361 |
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Article Suh, Sung-Suk Kim, Tai Kyoung Kim, Jung Eun Hong, Ju-Mi Nguyen, Trang Thu Thi Han, Se Jong Youn, Ui Joung Yim, Joung Han Kim, Il-Chan Anticancer Activity of Ramalin, a Secondary Metabolite from the Antarctic Lichen Ramalina terebrata, against Colorectal Cancer Cells |
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Colorectal cancer is a leading cause of death worldwide and occurs through the highly complex coordination of multiple cellular pathways, resulting in carcinogenesis. Recent studies have increasingly revealed that constituents of lichen extracts exhibit potent pharmaceutical activities, including anticancer activity against various cancer cells, making them promising candidates for new anticancer therapeutic drugs. The main objective of this study was to evaluate the anticancer capacities of ramalin, a secondary metabolite from the Antarctic lichen Ramalina terebrata, in the human colorectal cancer cell line HCT116. In this study, ramalin displayed concentration-dependent anticancer activity against HCT116 cells, significantly suppressing proliferation and inducing apoptosis. Furthermore, ramalin induced cell cycle arrest in the gap 2/mitosis (G2/M) phase through the modulation of hallmark genes involved in the G2/M phase transition, such as tumour protein p53 (TP53), cyclin-dependent kinase inhibitor 1A (CDKN1A), cyclin-dependent kinase 1 (CDK1) and cyclin B1 (CCNB1). At both the transcriptional and translational level, ramalin caused a gradual increase in the expression of TP53 and its downstream gene CDKN1A, while decreasing the expression of CDK1 and CCNB1 in a concentration-dependent manner. In addition, ramalin significantly inhibited the migration and invasion of colorectal cancer cells in a concentration-dependent manner. Taken together, these data suggest that ramalin may be a therapeutic candidate for the targeted therapy of colorectal cancer. |
format |
Text |
author |
Suh, Sung-Suk Kim, Tai Kyoung Kim, Jung Eun Hong, Ju-Mi Nguyen, Trang Thu Thi Han, Se Jong Youn, Ui Joung Yim, Joung Han Kim, Il-Chan |
author_facet |
Suh, Sung-Suk Kim, Tai Kyoung Kim, Jung Eun Hong, Ju-Mi Nguyen, Trang Thu Thi Han, Se Jong Youn, Ui Joung Yim, Joung Han Kim, Il-Chan |
author_sort |
Suh, Sung-Suk |
title |
Anticancer Activity of Ramalin, a Secondary Metabolite from the Antarctic Lichen Ramalina terebrata, against Colorectal Cancer Cells |
title_short |
Anticancer Activity of Ramalin, a Secondary Metabolite from the Antarctic Lichen Ramalina terebrata, against Colorectal Cancer Cells |
title_full |
Anticancer Activity of Ramalin, a Secondary Metabolite from the Antarctic Lichen Ramalina terebrata, against Colorectal Cancer Cells |
title_fullStr |
Anticancer Activity of Ramalin, a Secondary Metabolite from the Antarctic Lichen Ramalina terebrata, against Colorectal Cancer Cells |
title_full_unstemmed |
Anticancer Activity of Ramalin, a Secondary Metabolite from the Antarctic Lichen Ramalina terebrata, against Colorectal Cancer Cells |
title_sort |
anticancer activity of ramalin, a secondary metabolite from the antarctic lichen ramalina terebrata, against colorectal cancer cells |
publisher |
MDPI |
publishDate |
2017 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152360/ http://www.ncbi.nlm.nih.gov/pubmed/28817102 https://doi.org/10.3390/molecules22081361 |
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Antarctic The Antarctic |
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Antarctic The Antarctic |
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Antarc* Antarctic |
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Antarc* Antarctic |
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152360/ http://www.ncbi.nlm.nih.gov/pubmed/28817102 http://dx.doi.org/10.3390/molecules22081361 |
op_rights |
© 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
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CC-BY |
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https://doi.org/10.3390/molecules22081361 |
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