Bioactive Constituents from the Whole Plants of Gentianella acuta (Michx.) Hulten
As a Mongolian native medicine and Ewenki folk medicinal plant, Gentianella acuta has been widely used for the treatment of diarrhea, hepatitis, arrhythmia, and coronary heart disease. In the course of investigating efficacy compounds to treat diarrhea using a mouse isolated intestine tissue model,...
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ftpubmed:oai:pubmedcentral.nih.gov:6152096 2023-05-15T16:09:17+02:00 Bioactive Constituents from the Whole Plants of Gentianella acuta (Michx.) Hulten Ding, Zhijuan Liu, Yanxia Ruan, Jingya Yang, Shengcai Yu, Haiyang Chen, Meiling Zhang, Yi Wang, Tao 2017-08-06 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152096/ http://www.ncbi.nlm.nih.gov/pubmed/28783086 https://doi.org/10.3390/molecules22081309 en eng MDPI http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152096/ http://www.ncbi.nlm.nih.gov/pubmed/28783086 http://dx.doi.org/10.3390/molecules22081309 © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). CC-BY Article Text 2017 ftpubmed https://doi.org/10.3390/molecules22081309 2018-11-18T01:55:44Z As a Mongolian native medicine and Ewenki folk medicinal plant, Gentianella acuta has been widely used for the treatment of diarrhea, hepatitis, arrhythmia, and coronary heart disease. In the course of investigating efficacy compounds to treat diarrhea using a mouse isolated intestine tissue model, we found 70% EtOH extract of G. acuta whole plants had an inhibitory effect on intestine contraction tension. Here, nineteen constituents, including five new compounds, named as gentiiridosides A (1), B (2), gentilignanoside A (3), (1R)-2,2,3-trimethyl-4-hydroxymethylcyclopent-3-ene-1-methyl-O-β-d-glucopyranoside (4), and (3Z)-3-hexene-1,5-diol 1-O-α-l-arabinopyranosyl(1→6)-β-d-glucopyranoside (5) were obtained from it. The structures of them were elucidated by chemical and spectroscopic methods. Furthermore, the inhibitory effects on motility of mouse isolated intestine tissue of the above mentioned compounds and other thirteen iridoid- and secoiridoid-type monoterpenes (7–10, 13–16, 18, 19, 21, 22, and 25) previously obtained in the plant were analyzed. As results, new compound 5, some secoiridoid-type monoterpenes 7, 10, 12–14, 16, and 17, as well as 7-O-9′-type lignans 31 and 32 displayed significant inhibitory effect on contraction tension at 40 μM. Text Ewenki PubMed Central (PMC) Molecules 22 8 1309 |
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Article Ding, Zhijuan Liu, Yanxia Ruan, Jingya Yang, Shengcai Yu, Haiyang Chen, Meiling Zhang, Yi Wang, Tao Bioactive Constituents from the Whole Plants of Gentianella acuta (Michx.) Hulten |
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As a Mongolian native medicine and Ewenki folk medicinal plant, Gentianella acuta has been widely used for the treatment of diarrhea, hepatitis, arrhythmia, and coronary heart disease. In the course of investigating efficacy compounds to treat diarrhea using a mouse isolated intestine tissue model, we found 70% EtOH extract of G. acuta whole plants had an inhibitory effect on intestine contraction tension. Here, nineteen constituents, including five new compounds, named as gentiiridosides A (1), B (2), gentilignanoside A (3), (1R)-2,2,3-trimethyl-4-hydroxymethylcyclopent-3-ene-1-methyl-O-β-d-glucopyranoside (4), and (3Z)-3-hexene-1,5-diol 1-O-α-l-arabinopyranosyl(1→6)-β-d-glucopyranoside (5) were obtained from it. The structures of them were elucidated by chemical and spectroscopic methods. Furthermore, the inhibitory effects on motility of mouse isolated intestine tissue of the above mentioned compounds and other thirteen iridoid- and secoiridoid-type monoterpenes (7–10, 13–16, 18, 19, 21, 22, and 25) previously obtained in the plant were analyzed. As results, new compound 5, some secoiridoid-type monoterpenes 7, 10, 12–14, 16, and 17, as well as 7-O-9′-type lignans 31 and 32 displayed significant inhibitory effect on contraction tension at 40 μM. |
format |
Text |
author |
Ding, Zhijuan Liu, Yanxia Ruan, Jingya Yang, Shengcai Yu, Haiyang Chen, Meiling Zhang, Yi Wang, Tao |
author_facet |
Ding, Zhijuan Liu, Yanxia Ruan, Jingya Yang, Shengcai Yu, Haiyang Chen, Meiling Zhang, Yi Wang, Tao |
author_sort |
Ding, Zhijuan |
title |
Bioactive Constituents from the Whole Plants of Gentianella acuta (Michx.) Hulten |
title_short |
Bioactive Constituents from the Whole Plants of Gentianella acuta (Michx.) Hulten |
title_full |
Bioactive Constituents from the Whole Plants of Gentianella acuta (Michx.) Hulten |
title_fullStr |
Bioactive Constituents from the Whole Plants of Gentianella acuta (Michx.) Hulten |
title_full_unstemmed |
Bioactive Constituents from the Whole Plants of Gentianella acuta (Michx.) Hulten |
title_sort |
bioactive constituents from the whole plants of gentianella acuta (michx.) hulten |
publisher |
MDPI |
publishDate |
2017 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152096/ http://www.ncbi.nlm.nih.gov/pubmed/28783086 https://doi.org/10.3390/molecules22081309 |
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Ewenki |
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Ewenki |
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152096/ http://www.ncbi.nlm.nih.gov/pubmed/28783086 http://dx.doi.org/10.3390/molecules22081309 |
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© 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
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https://doi.org/10.3390/molecules22081309 |
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Molecules |
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