Risk Factors for Ventricular Septal Defects in Murmansk County, Russia: A Registry-Based Study
Cardiovascular malformations are one of the most common birth defects among newborns and constitute a leading cause of perinatal and infant mortality. Although some risk factors are recognized, the causes of cardiovascular malformations (CVMs) remain largely unknown. In this study, we aim to identif...
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ftpubmed:oai:pubmedcentral.nih.gov:6069126 2023-05-15T17:46:05+02:00 Risk Factors for Ventricular Septal Defects in Murmansk County, Russia: A Registry-Based Study Kovalenko, Anton A. Anda, Erik Eik Odland, Jon Øyvind Nieboer, Evert Brenn, Tormod Krettek, Alexandra 2018-06-24 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069126/ http://www.ncbi.nlm.nih.gov/pubmed/29937526 https://doi.org/10.3390/ijerph15071320 en eng MDPI http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069126/ http://www.ncbi.nlm.nih.gov/pubmed/29937526 http://dx.doi.org/10.3390/ijerph15071320 © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). CC-BY Article Text 2018 ftpubmed https://doi.org/10.3390/ijerph15071320 2018-08-12T00:21:14Z Cardiovascular malformations are one of the most common birth defects among newborns and constitute a leading cause of perinatal and infant mortality. Although some risk factors are recognized, the causes of cardiovascular malformations (CVMs) remain largely unknown. In this study, we aim to identify risk factors for ventricular septal defects (VSDs) in Northwest Russia. The study population included singleton births registered in the Murmansk County Birth Registry (MCBR) between 1 January 2006 and 31 December 2011. Infants with a diagnosis of VSD in the MCBR and/or in the Murmansk Regional Congenital Defects Registry (up to two years post-delivery) constituted the study sample. Among the 52,253 infants born during the study period there were 744 cases of septal heart defects (SHDs), which corresponds to a prevalence of 14.2 [95% confidence interval (CI) of 13.2–15.3] per 1000 infants. Logistic regression analyses were carried out to identify VSD risk factors. Increased risk of VSDs was observed among infants born to mothers who abused alcohol [OR = 4.83; 95% CI 1.88–12.41], or smoked during pregnancy [OR = 1.35; 95% CI 1.02–1.80]. Maternal diabetes mellitus was also a significant risk factor [OR = 8.72; 95% CI 3.16–24.07], while maternal age, body mass index, folic acid and multivitamin intake were not associated with increased risk. Overall risks of VSDs for male babies were lower [OR = 0.67; 95% CI 0.52–0.88]. Text Northwest Russia PubMed Central (PMC) Murmansk International Journal of Environmental Research and Public Health 15 7 1320 |
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Article Kovalenko, Anton A. Anda, Erik Eik Odland, Jon Øyvind Nieboer, Evert Brenn, Tormod Krettek, Alexandra Risk Factors for Ventricular Septal Defects in Murmansk County, Russia: A Registry-Based Study |
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Cardiovascular malformations are one of the most common birth defects among newborns and constitute a leading cause of perinatal and infant mortality. Although some risk factors are recognized, the causes of cardiovascular malformations (CVMs) remain largely unknown. In this study, we aim to identify risk factors for ventricular septal defects (VSDs) in Northwest Russia. The study population included singleton births registered in the Murmansk County Birth Registry (MCBR) between 1 January 2006 and 31 December 2011. Infants with a diagnosis of VSD in the MCBR and/or in the Murmansk Regional Congenital Defects Registry (up to two years post-delivery) constituted the study sample. Among the 52,253 infants born during the study period there were 744 cases of septal heart defects (SHDs), which corresponds to a prevalence of 14.2 [95% confidence interval (CI) of 13.2–15.3] per 1000 infants. Logistic regression analyses were carried out to identify VSD risk factors. Increased risk of VSDs was observed among infants born to mothers who abused alcohol [OR = 4.83; 95% CI 1.88–12.41], or smoked during pregnancy [OR = 1.35; 95% CI 1.02–1.80]. Maternal diabetes mellitus was also a significant risk factor [OR = 8.72; 95% CI 3.16–24.07], while maternal age, body mass index, folic acid and multivitamin intake were not associated with increased risk. Overall risks of VSDs for male babies were lower [OR = 0.67; 95% CI 0.52–0.88]. |
format |
Text |
author |
Kovalenko, Anton A. Anda, Erik Eik Odland, Jon Øyvind Nieboer, Evert Brenn, Tormod Krettek, Alexandra |
author_facet |
Kovalenko, Anton A. Anda, Erik Eik Odland, Jon Øyvind Nieboer, Evert Brenn, Tormod Krettek, Alexandra |
author_sort |
Kovalenko, Anton A. |
title |
Risk Factors for Ventricular Septal Defects in Murmansk County, Russia: A Registry-Based Study |
title_short |
Risk Factors for Ventricular Septal Defects in Murmansk County, Russia: A Registry-Based Study |
title_full |
Risk Factors for Ventricular Septal Defects in Murmansk County, Russia: A Registry-Based Study |
title_fullStr |
Risk Factors for Ventricular Septal Defects in Murmansk County, Russia: A Registry-Based Study |
title_full_unstemmed |
Risk Factors for Ventricular Septal Defects in Murmansk County, Russia: A Registry-Based Study |
title_sort |
risk factors for ventricular septal defects in murmansk county, russia: a registry-based study |
publisher |
MDPI |
publishDate |
2018 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069126/ http://www.ncbi.nlm.nih.gov/pubmed/29937526 https://doi.org/10.3390/ijerph15071320 |
geographic |
Murmansk |
geographic_facet |
Murmansk |
genre |
Northwest Russia |
genre_facet |
Northwest Russia |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069126/ http://www.ncbi.nlm.nih.gov/pubmed/29937526 http://dx.doi.org/10.3390/ijerph15071320 |
op_rights |
© 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.3390/ijerph15071320 |
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International Journal of Environmental Research and Public Health |
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15 |
container_issue |
7 |
container_start_page |
1320 |
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1766149446803914752 |