Leishmania major and Trypanosoma lewisi infection in invasive and native rodents in Senegal
Bioinvasion is a major public health issue because it can lead to the introduction of pathogens in new areas and favours the emergence of zoonotic diseases. Rodents are prominent invasive species, and act as reservoirs in many zoonotic infectious diseases. The aim of this study was to determine the...
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ftpubmed:oai:pubmedcentral.nih.gov:6042788 2023-05-15T18:05:32+02:00 Leishmania major and Trypanosoma lewisi infection in invasive and native rodents in Senegal Cassan, Cécile Diagne, Christophe A. Tatard, Caroline Gauthier, Philippe Dalecky, Ambroise Bâ, Khalilou Kane, Mamadou Niang, Youssoupha Diallo, Mamoudou Sow, Aliou Brouat, Carine Bañuls, Anne-Laure 2018-06-29 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042788/ http://www.ncbi.nlm.nih.gov/pubmed/29958273 https://doi.org/10.1371/journal.pntd.0006615 en eng Public Library of Science http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042788/ http://www.ncbi.nlm.nih.gov/pubmed/29958273 http://dx.doi.org/10.1371/journal.pntd.0006615 © 2018 Cassan et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. CC-BY Research Article Text 2018 ftpubmed https://doi.org/10.1371/journal.pntd.0006615 2018-07-29T00:12:20Z Bioinvasion is a major public health issue because it can lead to the introduction of pathogens in new areas and favours the emergence of zoonotic diseases. Rodents are prominent invasive species, and act as reservoirs in many zoonotic infectious diseases. The aim of this study was to determine the link between the distribution and spread of two parasite taxa (Leishmania spp. and Trypanosoma lewisi) and the progressive invasion of Senegal by two commensal rodent species (the house mouse Mus musculus domesticus and the black rat Rattus rattus). M. m. domesticus and R. rattus have invaded the northern part and the central/southern part of the country, respectively. Native and invasive rodents were caught in villages and cities along the invasion gradients of both invaders, from coastal localities towards the interior of the land. Molecular diagnosis of the two trypanosomatid infections was performed using spleen specimens. In the north, neither M. m. domesticus nor the native species were carriers of these parasites. Conversely, in the south, 17.5% of R. rattus were infected by L. major and 27.8% by T. lewisi, while very few commensal native rodents were carriers. Prevalence pattern along invasion gradients, together with the knowledge on the geographical distribution of the parasites, suggested that the presence of the two parasites in R. rattus in Senegal is of different origins. Indeed, the invader R. rattus could have been locally infected by the native parasite L. major. Conversely, it could have introduced the exotic parasite T. lewisi in Senegal, the latter appearing to be poorly transmitted to native rodents. Altogether, these data show that R. rattus is a carrier of both parasites and could be responsible for the emergence of new foci of cutaneous leishmaniasis, or for the transmission of atypical human trypanosomiasis in Senegal. Text Rattus rattus PubMed Central (PMC) PLOS Neglected Tropical Diseases 12 6 e0006615 |
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Research Article Cassan, Cécile Diagne, Christophe A. Tatard, Caroline Gauthier, Philippe Dalecky, Ambroise Bâ, Khalilou Kane, Mamadou Niang, Youssoupha Diallo, Mamoudou Sow, Aliou Brouat, Carine Bañuls, Anne-Laure Leishmania major and Trypanosoma lewisi infection in invasive and native rodents in Senegal |
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Research Article |
description |
Bioinvasion is a major public health issue because it can lead to the introduction of pathogens in new areas and favours the emergence of zoonotic diseases. Rodents are prominent invasive species, and act as reservoirs in many zoonotic infectious diseases. The aim of this study was to determine the link between the distribution and spread of two parasite taxa (Leishmania spp. and Trypanosoma lewisi) and the progressive invasion of Senegal by two commensal rodent species (the house mouse Mus musculus domesticus and the black rat Rattus rattus). M. m. domesticus and R. rattus have invaded the northern part and the central/southern part of the country, respectively. Native and invasive rodents were caught in villages and cities along the invasion gradients of both invaders, from coastal localities towards the interior of the land. Molecular diagnosis of the two trypanosomatid infections was performed using spleen specimens. In the north, neither M. m. domesticus nor the native species were carriers of these parasites. Conversely, in the south, 17.5% of R. rattus were infected by L. major and 27.8% by T. lewisi, while very few commensal native rodents were carriers. Prevalence pattern along invasion gradients, together with the knowledge on the geographical distribution of the parasites, suggested that the presence of the two parasites in R. rattus in Senegal is of different origins. Indeed, the invader R. rattus could have been locally infected by the native parasite L. major. Conversely, it could have introduced the exotic parasite T. lewisi in Senegal, the latter appearing to be poorly transmitted to native rodents. Altogether, these data show that R. rattus is a carrier of both parasites and could be responsible for the emergence of new foci of cutaneous leishmaniasis, or for the transmission of atypical human trypanosomiasis in Senegal. |
format |
Text |
author |
Cassan, Cécile Diagne, Christophe A. Tatard, Caroline Gauthier, Philippe Dalecky, Ambroise Bâ, Khalilou Kane, Mamadou Niang, Youssoupha Diallo, Mamoudou Sow, Aliou Brouat, Carine Bañuls, Anne-Laure |
author_facet |
Cassan, Cécile Diagne, Christophe A. Tatard, Caroline Gauthier, Philippe Dalecky, Ambroise Bâ, Khalilou Kane, Mamadou Niang, Youssoupha Diallo, Mamoudou Sow, Aliou Brouat, Carine Bañuls, Anne-Laure |
author_sort |
Cassan, Cécile |
title |
Leishmania major and Trypanosoma lewisi infection in invasive and native rodents in Senegal |
title_short |
Leishmania major and Trypanosoma lewisi infection in invasive and native rodents in Senegal |
title_full |
Leishmania major and Trypanosoma lewisi infection in invasive and native rodents in Senegal |
title_fullStr |
Leishmania major and Trypanosoma lewisi infection in invasive and native rodents in Senegal |
title_full_unstemmed |
Leishmania major and Trypanosoma lewisi infection in invasive and native rodents in Senegal |
title_sort |
leishmania major and trypanosoma lewisi infection in invasive and native rodents in senegal |
publisher |
Public Library of Science |
publishDate |
2018 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042788/ http://www.ncbi.nlm.nih.gov/pubmed/29958273 https://doi.org/10.1371/journal.pntd.0006615 |
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Rattus rattus |
genre_facet |
Rattus rattus |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042788/ http://www.ncbi.nlm.nih.gov/pubmed/29958273 http://dx.doi.org/10.1371/journal.pntd.0006615 |
op_rights |
© 2018 Cassan et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
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CC-BY |
op_doi |
https://doi.org/10.1371/journal.pntd.0006615 |
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PLOS Neglected Tropical Diseases |
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12 |
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6 |
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e0006615 |
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1766177019920384000 |