Independent losses of a xenobiotic receptor across teleost evolution
Sensitivity to environmental stressors largely depend on the genetic complement of the organism. Recent sequencing and assembly of teleost fish genomes enable us to trace the evolution of defense genes in the largest and most diverse group of vertebrates. Through genomic searches and in-depth analys...
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ftpubmed:oai:pubmedcentral.nih.gov:6039460 2023-05-15T15:27:33+02:00 Independent losses of a xenobiotic receptor across teleost evolution Eide, Marta Rydbeck, Halfdan Tørresen, Ole K. Lille-Langøy, Roger Puntervoll, Pål Goldstone, Jared V. Jakobsen, Kjetill S. Stegeman, John Goksøyr, Anders Karlsen, Odd A. 2018-07-10 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039460/ http://www.ncbi.nlm.nih.gov/pubmed/29991818 https://doi.org/10.1038/s41598-018-28498-4 en eng Nature Publishing Group UK http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039460/ http://www.ncbi.nlm.nih.gov/pubmed/29991818 http://dx.doi.org/10.1038/s41598-018-28498-4 © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. CC-BY Article Text 2018 ftpubmed https://doi.org/10.1038/s41598-018-28498-4 2018-07-15T00:29:31Z Sensitivity to environmental stressors largely depend on the genetic complement of the organism. Recent sequencing and assembly of teleost fish genomes enable us to trace the evolution of defense genes in the largest and most diverse group of vertebrates. Through genomic searches and in-depth analysis of gene loci in 76 teleost genomes, we show here that the xenosensor pregnane X receptor (Pxr, Nr1i2) is absent in more than half of these species. Notably, out of the 27 genome assemblies that belong to the Gadiformes order, the pxr gene was only retained in the Merluccidae family (hakes) and Pelagic cod (Melanonus zugmayeri). As an important receptor for a wide range of drugs and environmental pollutants, vertebrate PXR regulate the transcription of a number of genes involved in the biotransformation of xenobiotics, including cytochrome P450 enzymes (CYP). In the absence of Pxr, we suggest that the aryl hydrocarbon receptor (Ahr) have evolved an extended regulatory role by governing the expression of certain Pxr target genes, such as cyp3a, in Atlantic cod (Gadus morhua). However, as several independent losses of pxr have occurred during teleost evolution, other lineages and species may have adapted alternative compensating mechanisms for controlling crucial cellular defense mechanisms. Text atlantic cod Gadus morhua PubMed Central (PMC) Scientific Reports 8 1 |
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Article Eide, Marta Rydbeck, Halfdan Tørresen, Ole K. Lille-Langøy, Roger Puntervoll, Pål Goldstone, Jared V. Jakobsen, Kjetill S. Stegeman, John Goksøyr, Anders Karlsen, Odd A. Independent losses of a xenobiotic receptor across teleost evolution |
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description |
Sensitivity to environmental stressors largely depend on the genetic complement of the organism. Recent sequencing and assembly of teleost fish genomes enable us to trace the evolution of defense genes in the largest and most diverse group of vertebrates. Through genomic searches and in-depth analysis of gene loci in 76 teleost genomes, we show here that the xenosensor pregnane X receptor (Pxr, Nr1i2) is absent in more than half of these species. Notably, out of the 27 genome assemblies that belong to the Gadiformes order, the pxr gene was only retained in the Merluccidae family (hakes) and Pelagic cod (Melanonus zugmayeri). As an important receptor for a wide range of drugs and environmental pollutants, vertebrate PXR regulate the transcription of a number of genes involved in the biotransformation of xenobiotics, including cytochrome P450 enzymes (CYP). In the absence of Pxr, we suggest that the aryl hydrocarbon receptor (Ahr) have evolved an extended regulatory role by governing the expression of certain Pxr target genes, such as cyp3a, in Atlantic cod (Gadus morhua). However, as several independent losses of pxr have occurred during teleost evolution, other lineages and species may have adapted alternative compensating mechanisms for controlling crucial cellular defense mechanisms. |
format |
Text |
author |
Eide, Marta Rydbeck, Halfdan Tørresen, Ole K. Lille-Langøy, Roger Puntervoll, Pål Goldstone, Jared V. Jakobsen, Kjetill S. Stegeman, John Goksøyr, Anders Karlsen, Odd A. |
author_facet |
Eide, Marta Rydbeck, Halfdan Tørresen, Ole K. Lille-Langøy, Roger Puntervoll, Pål Goldstone, Jared V. Jakobsen, Kjetill S. Stegeman, John Goksøyr, Anders Karlsen, Odd A. |
author_sort |
Eide, Marta |
title |
Independent losses of a xenobiotic receptor across teleost evolution |
title_short |
Independent losses of a xenobiotic receptor across teleost evolution |
title_full |
Independent losses of a xenobiotic receptor across teleost evolution |
title_fullStr |
Independent losses of a xenobiotic receptor across teleost evolution |
title_full_unstemmed |
Independent losses of a xenobiotic receptor across teleost evolution |
title_sort |
independent losses of a xenobiotic receptor across teleost evolution |
publisher |
Nature Publishing Group UK |
publishDate |
2018 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039460/ http://www.ncbi.nlm.nih.gov/pubmed/29991818 https://doi.org/10.1038/s41598-018-28498-4 |
genre |
atlantic cod Gadus morhua |
genre_facet |
atlantic cod Gadus morhua |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039460/ http://www.ncbi.nlm.nih.gov/pubmed/29991818 http://dx.doi.org/10.1038/s41598-018-28498-4 |
op_rights |
© The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1038/s41598-018-28498-4 |
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Scientific Reports |
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8 |
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