Atmospheric Precipitations, Hailstone and Rainwater, as a Novel Source of Streptomyces Producing Bioactive Natural Products
A cultivation-dependent approach revealed that highly diverse populations of Streptomyces were present in atmospheric precipitations from a hailstorm event sampled in February 2016 in the Cantabrian Sea coast, North of Spain. A total of 29 bioactive Streptomyces strains isolated from small samples o...
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ftpubmed:oai:pubmedcentral.nih.gov:5924784 2023-05-15T15:13:37+02:00 Atmospheric Precipitations, Hailstone and Rainwater, as a Novel Source of Streptomyces Producing Bioactive Natural Products Sarmiento-Vizcaíno, Aida Espadas, Julia Martín, Jesús Braña, Alfredo F. Reyes, Fernando García, Luis A. Blanco, Gloria 2018-04-23 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5924784/ http://www.ncbi.nlm.nih.gov/pubmed/29740412 https://doi.org/10.3389/fmicb.2018.00773 en eng Frontiers Media S.A. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5924784/ http://www.ncbi.nlm.nih.gov/pubmed/29740412 http://dx.doi.org/10.3389/fmicb.2018.00773 Copyright © 2018 Sarmiento-Vizcaíno, Espadas, Martín, Braña, Reyes, García and Blanco. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. CC-BY Microbiology Text 2018 ftpubmed https://doi.org/10.3389/fmicb.2018.00773 2018-05-13T00:11:06Z A cultivation-dependent approach revealed that highly diverse populations of Streptomyces were present in atmospheric precipitations from a hailstorm event sampled in February 2016 in the Cantabrian Sea coast, North of Spain. A total of 29 bioactive Streptomyces strains isolated from small samples of hailstone and rainwater, collected from this hailstorm event, were studied here. Taxonomic identification by 16S rRNA sequencing revealed more than 20 different Streptomyces species, with their closest homologs displaying mainly oceanic but also terrestrial origins. Backward trajectory analysis revealed that the air-mass sources of the hailstorm event, with North Western winds, were originated in the Arctic Ocean (West Greenland and North Iceland) and Canada (Labrador), depending on the altitude. After traveling across the North Atlantic Ocean during 4 days the air mass reached Europe and precipitated as hailstone and rain water at the sampling place in Spain. The finding of Streptomyces species able to survive and disperse through the atmosphere increases our knowledge of the biogeography of genus Streptomyces on Earth, and reinforces our previous dispersion model, suggesting a generalized feature for the genus which could have been essential in his evolution. This unique atmospheric-derived Streptomyces collection was screened for production of bioactive secondary metabolites. Analyses of isolates ethyl acetate extracts by LC-UV-MS and further database comparison revealed an extraordinary diversity of bioactive natural products. One hundred molecules were identified, mostly displaying contrasted antibiotic and antitumor/cytotoxic activities, but also antiparasitic, antiviral, anti-inflammatory, neuroprotector, and insecticide properties. More interestingly, 38 molecules not identified in natural products databases might represent new natural products. Our results revealed for the first time an extraordinary diversity of Streptomyces species in the atmosphere able to produce an extraordinary repertoire of bioactive ... Text Arctic Arctic Ocean Greenland Iceland North Atlantic PubMed Central (PMC) Arctic Arctic Ocean Canada Greenland Frontiers in Microbiology 9 |
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English |
topic |
Microbiology |
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Microbiology Sarmiento-Vizcaíno, Aida Espadas, Julia Martín, Jesús Braña, Alfredo F. Reyes, Fernando García, Luis A. Blanco, Gloria Atmospheric Precipitations, Hailstone and Rainwater, as a Novel Source of Streptomyces Producing Bioactive Natural Products |
topic_facet |
Microbiology |
description |
A cultivation-dependent approach revealed that highly diverse populations of Streptomyces were present in atmospheric precipitations from a hailstorm event sampled in February 2016 in the Cantabrian Sea coast, North of Spain. A total of 29 bioactive Streptomyces strains isolated from small samples of hailstone and rainwater, collected from this hailstorm event, were studied here. Taxonomic identification by 16S rRNA sequencing revealed more than 20 different Streptomyces species, with their closest homologs displaying mainly oceanic but also terrestrial origins. Backward trajectory analysis revealed that the air-mass sources of the hailstorm event, with North Western winds, were originated in the Arctic Ocean (West Greenland and North Iceland) and Canada (Labrador), depending on the altitude. After traveling across the North Atlantic Ocean during 4 days the air mass reached Europe and precipitated as hailstone and rain water at the sampling place in Spain. The finding of Streptomyces species able to survive and disperse through the atmosphere increases our knowledge of the biogeography of genus Streptomyces on Earth, and reinforces our previous dispersion model, suggesting a generalized feature for the genus which could have been essential in his evolution. This unique atmospheric-derived Streptomyces collection was screened for production of bioactive secondary metabolites. Analyses of isolates ethyl acetate extracts by LC-UV-MS and further database comparison revealed an extraordinary diversity of bioactive natural products. One hundred molecules were identified, mostly displaying contrasted antibiotic and antitumor/cytotoxic activities, but also antiparasitic, antiviral, anti-inflammatory, neuroprotector, and insecticide properties. More interestingly, 38 molecules not identified in natural products databases might represent new natural products. Our results revealed for the first time an extraordinary diversity of Streptomyces species in the atmosphere able to produce an extraordinary repertoire of bioactive ... |
format |
Text |
author |
Sarmiento-Vizcaíno, Aida Espadas, Julia Martín, Jesús Braña, Alfredo F. Reyes, Fernando García, Luis A. Blanco, Gloria |
author_facet |
Sarmiento-Vizcaíno, Aida Espadas, Julia Martín, Jesús Braña, Alfredo F. Reyes, Fernando García, Luis A. Blanco, Gloria |
author_sort |
Sarmiento-Vizcaíno, Aida |
title |
Atmospheric Precipitations, Hailstone and Rainwater, as a Novel Source of Streptomyces Producing Bioactive Natural Products |
title_short |
Atmospheric Precipitations, Hailstone and Rainwater, as a Novel Source of Streptomyces Producing Bioactive Natural Products |
title_full |
Atmospheric Precipitations, Hailstone and Rainwater, as a Novel Source of Streptomyces Producing Bioactive Natural Products |
title_fullStr |
Atmospheric Precipitations, Hailstone and Rainwater, as a Novel Source of Streptomyces Producing Bioactive Natural Products |
title_full_unstemmed |
Atmospheric Precipitations, Hailstone and Rainwater, as a Novel Source of Streptomyces Producing Bioactive Natural Products |
title_sort |
atmospheric precipitations, hailstone and rainwater, as a novel source of streptomyces producing bioactive natural products |
publisher |
Frontiers Media S.A. |
publishDate |
2018 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5924784/ http://www.ncbi.nlm.nih.gov/pubmed/29740412 https://doi.org/10.3389/fmicb.2018.00773 |
geographic |
Arctic Arctic Ocean Canada Greenland |
geographic_facet |
Arctic Arctic Ocean Canada Greenland |
genre |
Arctic Arctic Ocean Greenland Iceland North Atlantic |
genre_facet |
Arctic Arctic Ocean Greenland Iceland North Atlantic |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5924784/ http://www.ncbi.nlm.nih.gov/pubmed/29740412 http://dx.doi.org/10.3389/fmicb.2018.00773 |
op_rights |
Copyright © 2018 Sarmiento-Vizcaíno, Espadas, Martín, Braña, Reyes, García and Blanco. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.3389/fmicb.2018.00773 |
container_title |
Frontiers in Microbiology |
container_volume |
9 |
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1766344146022301696 |