Pharmacokinetic and Tissue Distribution of Fucoidan from Fucus vesiculosus after Oral Administration to Rats
Fucus vesiculosus L., known as bladderwrack, belongs to the brown seaweeds, which are widely distributed throughout northern Russia, Atlantic shores of Europe, the Baltic Sea, Greenland, the Azores, the Canary Islands, and shores of the Pacific Ocean. Fucoidan is a major fucose-rich sulfated polysac...
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ftpubmed:oai:pubmedcentral.nih.gov:5923419 2023-05-15T16:29:39+02:00 Pharmacokinetic and Tissue Distribution of Fucoidan from Fucus vesiculosus after Oral Administration to Rats Pozharitskaya, Olga N. Shikov, Alexander N. Faustova, Natalya M. Obluchinskaya, Ekaterina D. Kosman, Vera M. Vuorela, Heikki Makarov, Valery G. 2018-04-18 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923419/ http://www.ncbi.nlm.nih.gov/pubmed/29669995 https://doi.org/10.3390/md16040132 en eng MDPI http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923419/ http://www.ncbi.nlm.nih.gov/pubmed/29669995 http://dx.doi.org/10.3390/md16040132 © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). CC-BY Article Text 2018 ftpubmed https://doi.org/10.3390/md16040132 2018-05-06T00:36:40Z Fucus vesiculosus L., known as bladderwrack, belongs to the brown seaweeds, which are widely distributed throughout northern Russia, Atlantic shores of Europe, the Baltic Sea, Greenland, the Azores, the Canary Islands, and shores of the Pacific Ocean. Fucoidan is a major fucose-rich sulfated polysaccharide found in Fucus (F.) vesiculosus. The pharmacokinetic profiling of active compounds is essential for drug development and approval. The aim of the study was to evaluate the pharmacokinetics and tissue distribution of fucoidan in rats after a single-dose oral administration. Fucoidan was isolated from F. vesiculosus. The method of measuring anti-activated factor X (anti-Xa) activity by amidolytic assay was used to analyze the plasma and tissue concentrations of fucoidan. The tissue distribution of fucoidan after intragastric administration to the rats was characterized, and it exhibited considerable heterogeneity. Fucoidan preferentially accumulates in the kidneys (AUC0–t = 10.74 µg·h/g; Cmax = 1.23 µg/g after 5 h), spleen (AUC0–t = 6.89 µg·h/g; Cmax = 0.78 µg/g after 3 h), and liver (AUC0–t = 3.26 µg·h/g; Cmax = 0.53 µg/g after 2 h) and shows a relatively long absorption time and extended circulation in the blood, with a mean residence time (MRT) = 6.79 h. The outcome of this study provides additional scientific data for traditional use of fucoidan-containing plants and offers tangible support for the continued development of new effective pharmaceuticals using fucoidan. Text Greenland PubMed Central (PMC) Greenland Pacific Marine Drugs 16 4 132 |
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Article Pozharitskaya, Olga N. Shikov, Alexander N. Faustova, Natalya M. Obluchinskaya, Ekaterina D. Kosman, Vera M. Vuorela, Heikki Makarov, Valery G. Pharmacokinetic and Tissue Distribution of Fucoidan from Fucus vesiculosus after Oral Administration to Rats |
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Article |
description |
Fucus vesiculosus L., known as bladderwrack, belongs to the brown seaweeds, which are widely distributed throughout northern Russia, Atlantic shores of Europe, the Baltic Sea, Greenland, the Azores, the Canary Islands, and shores of the Pacific Ocean. Fucoidan is a major fucose-rich sulfated polysaccharide found in Fucus (F.) vesiculosus. The pharmacokinetic profiling of active compounds is essential for drug development and approval. The aim of the study was to evaluate the pharmacokinetics and tissue distribution of fucoidan in rats after a single-dose oral administration. Fucoidan was isolated from F. vesiculosus. The method of measuring anti-activated factor X (anti-Xa) activity by amidolytic assay was used to analyze the plasma and tissue concentrations of fucoidan. The tissue distribution of fucoidan after intragastric administration to the rats was characterized, and it exhibited considerable heterogeneity. Fucoidan preferentially accumulates in the kidneys (AUC0–t = 10.74 µg·h/g; Cmax = 1.23 µg/g after 5 h), spleen (AUC0–t = 6.89 µg·h/g; Cmax = 0.78 µg/g after 3 h), and liver (AUC0–t = 3.26 µg·h/g; Cmax = 0.53 µg/g after 2 h) and shows a relatively long absorption time and extended circulation in the blood, with a mean residence time (MRT) = 6.79 h. The outcome of this study provides additional scientific data for traditional use of fucoidan-containing plants and offers tangible support for the continued development of new effective pharmaceuticals using fucoidan. |
format |
Text |
author |
Pozharitskaya, Olga N. Shikov, Alexander N. Faustova, Natalya M. Obluchinskaya, Ekaterina D. Kosman, Vera M. Vuorela, Heikki Makarov, Valery G. |
author_facet |
Pozharitskaya, Olga N. Shikov, Alexander N. Faustova, Natalya M. Obluchinskaya, Ekaterina D. Kosman, Vera M. Vuorela, Heikki Makarov, Valery G. |
author_sort |
Pozharitskaya, Olga N. |
title |
Pharmacokinetic and Tissue Distribution of Fucoidan from Fucus vesiculosus after Oral Administration to Rats |
title_short |
Pharmacokinetic and Tissue Distribution of Fucoidan from Fucus vesiculosus after Oral Administration to Rats |
title_full |
Pharmacokinetic and Tissue Distribution of Fucoidan from Fucus vesiculosus after Oral Administration to Rats |
title_fullStr |
Pharmacokinetic and Tissue Distribution of Fucoidan from Fucus vesiculosus after Oral Administration to Rats |
title_full_unstemmed |
Pharmacokinetic and Tissue Distribution of Fucoidan from Fucus vesiculosus after Oral Administration to Rats |
title_sort |
pharmacokinetic and tissue distribution of fucoidan from fucus vesiculosus after oral administration to rats |
publisher |
MDPI |
publishDate |
2018 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923419/ http://www.ncbi.nlm.nih.gov/pubmed/29669995 https://doi.org/10.3390/md16040132 |
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Greenland Pacific |
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Greenland Pacific |
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Greenland |
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Greenland |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923419/ http://www.ncbi.nlm.nih.gov/pubmed/29669995 http://dx.doi.org/10.3390/md16040132 |
op_rights |
© 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
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CC-BY |
op_doi |
https://doi.org/10.3390/md16040132 |
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Marine Drugs |
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16 |
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132 |
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