Antiviral Defense and Innate Immune Memory in the Oyster
The Pacific oyster, Crassostrea gigas, is becoming a valuable model for investigating antiviral defense in the Lophotrochozoa superphylum. In the past five years, improvements to laboratory-based experimental infection protocols using Ostreid herpesvirus I (OsHV-1) from naturally infected C. gigas c...
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ftpubmed:oai:pubmedcentral.nih.gov:5869526 2023-05-15T15:58:34+02:00 Antiviral Defense and Innate Immune Memory in the Oyster Green, Timothy J. Speck, Peter 2018-03-16 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869526/ http://www.ncbi.nlm.nih.gov/pubmed/29547519 https://doi.org/10.3390/v10030133 en eng MDPI http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869526/ http://www.ncbi.nlm.nih.gov/pubmed/29547519 http://dx.doi.org/10.3390/v10030133 © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). CC-BY Review Text 2018 ftpubmed https://doi.org/10.3390/v10030133 2018-04-01T00:26:45Z The Pacific oyster, Crassostrea gigas, is becoming a valuable model for investigating antiviral defense in the Lophotrochozoa superphylum. In the past five years, improvements to laboratory-based experimental infection protocols using Ostreid herpesvirus I (OsHV-1) from naturally infected C. gigas combined with next-generation sequencing techniques has revealed that oysters have a complex antiviral response involving the activation of all major innate immune pathways. Experimental evidence indicates C. gigas utilizes an interferon-like response to limit OsHV-1 replication and spread. Oysters injected with a viral mimic (polyI:C) develop resistance to OsHV-1. Improved survival following polyI:C injection was found later in life (within-generational immune priming) and in the next generation (multi-generational immune priming). These studies indicate that the oyster’s antiviral defense system exhibits a form of innate immune-memory. An important priority is to identify the molecular mechanisms responsible for this phenomenon. This knowledge will motivate the development of practical and cost-effective treatments for improving oyster health in aquaculture. Text Crassostrea gigas Pacific oyster PubMed Central (PMC) Pacific Viruses 10 3 133 |
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Review Green, Timothy J. Speck, Peter Antiviral Defense and Innate Immune Memory in the Oyster |
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description |
The Pacific oyster, Crassostrea gigas, is becoming a valuable model for investigating antiviral defense in the Lophotrochozoa superphylum. In the past five years, improvements to laboratory-based experimental infection protocols using Ostreid herpesvirus I (OsHV-1) from naturally infected C. gigas combined with next-generation sequencing techniques has revealed that oysters have a complex antiviral response involving the activation of all major innate immune pathways. Experimental evidence indicates C. gigas utilizes an interferon-like response to limit OsHV-1 replication and spread. Oysters injected with a viral mimic (polyI:C) develop resistance to OsHV-1. Improved survival following polyI:C injection was found later in life (within-generational immune priming) and in the next generation (multi-generational immune priming). These studies indicate that the oyster’s antiviral defense system exhibits a form of innate immune-memory. An important priority is to identify the molecular mechanisms responsible for this phenomenon. This knowledge will motivate the development of practical and cost-effective treatments for improving oyster health in aquaculture. |
format |
Text |
author |
Green, Timothy J. Speck, Peter |
author_facet |
Green, Timothy J. Speck, Peter |
author_sort |
Green, Timothy J. |
title |
Antiviral Defense and Innate Immune Memory in the Oyster |
title_short |
Antiviral Defense and Innate Immune Memory in the Oyster |
title_full |
Antiviral Defense and Innate Immune Memory in the Oyster |
title_fullStr |
Antiviral Defense and Innate Immune Memory in the Oyster |
title_full_unstemmed |
Antiviral Defense and Innate Immune Memory in the Oyster |
title_sort |
antiviral defense and innate immune memory in the oyster |
publisher |
MDPI |
publishDate |
2018 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869526/ http://www.ncbi.nlm.nih.gov/pubmed/29547519 https://doi.org/10.3390/v10030133 |
geographic |
Pacific |
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Pacific |
genre |
Crassostrea gigas Pacific oyster |
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Crassostrea gigas Pacific oyster |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869526/ http://www.ncbi.nlm.nih.gov/pubmed/29547519 http://dx.doi.org/10.3390/v10030133 |
op_rights |
© 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
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CC-BY |
op_doi |
https://doi.org/10.3390/v10030133 |
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Viruses |
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10 |
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3 |
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133 |
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