Piscine orthoreovirus infection in Atlantic salmon (Salmo salar) protects against subsequent challenge with infectious hematopoietic necrosis virus (IHNV)
Infectious hematopoietic necrosis virus (IHNV) is endemic in farmed rainbow trout in continental Europe and in various salmonid fish species at the Pacific coast of North America. IHN has never occurred in European Atlantic salmon (Salmo salar) farms, but is considered as a major threat for the Euro...
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ftpubmed:oai:pubmedcentral.nih.gov:5850924 2023-05-15T15:29:29+02:00 Piscine orthoreovirus infection in Atlantic salmon (Salmo salar) protects against subsequent challenge with infectious hematopoietic necrosis virus (IHNV) Vendramin, Niccoló Alencar, Anna Luiza Farias Iburg, Tine Moesgaard Dahle, Maria Krudtaa Wessel, Øystein Olsen, Anne Berit Rimstad, Espen Olesen, Niels Jørgen 2018-03-13 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5850924/ http://www.ncbi.nlm.nih.gov/pubmed/29534748 https://doi.org/10.1186/s13567-018-0524-z en eng BioMed Central http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5850924/ http://www.ncbi.nlm.nih.gov/pubmed/29534748 http://dx.doi.org/10.1186/s13567-018-0524-z © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. CC0 PDM CC-BY Research Article Text 2018 ftpubmed https://doi.org/10.1186/s13567-018-0524-z 2018-03-25T01:03:59Z Infectious hematopoietic necrosis virus (IHNV) is endemic in farmed rainbow trout in continental Europe and in various salmonid fish species at the Pacific coast of North America. IHN has never occurred in European Atlantic salmon (Salmo salar) farms, but is considered as a major threat for the European salmon industry. Another virus, Piscine orthoreovirus (PRV), is widespread in the sea phase of Atlantic salmon, and is identified as the causative agent of heart and skeletal muscle inflammation. The aim of this study was to investigate the interactions between a primary PRV infection and a secondary IHNV infection under experimental conditions. A PRV cohabitation challenge was performed with Atlantic salmon. At peak of PRV viremia the fish were challenged by immersion with an IHNV genogroup E isolate. Clinical signs and morbidity were monitored. Target organs were sampled at selected time points to assess viral loads of both pathogens. Antiviral immune response and presence of histopathological findings were also investigated. Whereas the PRV-negative/IHNV positive group suffered significant decrease in survival caused by IHNV, the PRV infected groups did not suffer any morbidity and showed negligible levels of IHNV infection. Antiviral response genes were induced, as measured in spleen samples, from PRV infected fish prior to IHNV challenge. In conclusion, PRV-infection protects Atlantic salmon against IHNV infection and morbidity, most likely by inducing a protective innate antiviral response. Text Atlantic salmon Salmo salar PubMed Central (PMC) Pacific Veterinary Research 49 1 |
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Research Article Vendramin, Niccoló Alencar, Anna Luiza Farias Iburg, Tine Moesgaard Dahle, Maria Krudtaa Wessel, Øystein Olsen, Anne Berit Rimstad, Espen Olesen, Niels Jørgen Piscine orthoreovirus infection in Atlantic salmon (Salmo salar) protects against subsequent challenge with infectious hematopoietic necrosis virus (IHNV) |
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Research Article |
description |
Infectious hematopoietic necrosis virus (IHNV) is endemic in farmed rainbow trout in continental Europe and in various salmonid fish species at the Pacific coast of North America. IHN has never occurred in European Atlantic salmon (Salmo salar) farms, but is considered as a major threat for the European salmon industry. Another virus, Piscine orthoreovirus (PRV), is widespread in the sea phase of Atlantic salmon, and is identified as the causative agent of heart and skeletal muscle inflammation. The aim of this study was to investigate the interactions between a primary PRV infection and a secondary IHNV infection under experimental conditions. A PRV cohabitation challenge was performed with Atlantic salmon. At peak of PRV viremia the fish were challenged by immersion with an IHNV genogroup E isolate. Clinical signs and morbidity were monitored. Target organs were sampled at selected time points to assess viral loads of both pathogens. Antiviral immune response and presence of histopathological findings were also investigated. Whereas the PRV-negative/IHNV positive group suffered significant decrease in survival caused by IHNV, the PRV infected groups did not suffer any morbidity and showed negligible levels of IHNV infection. Antiviral response genes were induced, as measured in spleen samples, from PRV infected fish prior to IHNV challenge. In conclusion, PRV-infection protects Atlantic salmon against IHNV infection and morbidity, most likely by inducing a protective innate antiviral response. |
format |
Text |
author |
Vendramin, Niccoló Alencar, Anna Luiza Farias Iburg, Tine Moesgaard Dahle, Maria Krudtaa Wessel, Øystein Olsen, Anne Berit Rimstad, Espen Olesen, Niels Jørgen |
author_facet |
Vendramin, Niccoló Alencar, Anna Luiza Farias Iburg, Tine Moesgaard Dahle, Maria Krudtaa Wessel, Øystein Olsen, Anne Berit Rimstad, Espen Olesen, Niels Jørgen |
author_sort |
Vendramin, Niccoló |
title |
Piscine orthoreovirus infection in Atlantic salmon (Salmo salar) protects against subsequent challenge with infectious hematopoietic necrosis virus (IHNV) |
title_short |
Piscine orthoreovirus infection in Atlantic salmon (Salmo salar) protects against subsequent challenge with infectious hematopoietic necrosis virus (IHNV) |
title_full |
Piscine orthoreovirus infection in Atlantic salmon (Salmo salar) protects against subsequent challenge with infectious hematopoietic necrosis virus (IHNV) |
title_fullStr |
Piscine orthoreovirus infection in Atlantic salmon (Salmo salar) protects against subsequent challenge with infectious hematopoietic necrosis virus (IHNV) |
title_full_unstemmed |
Piscine orthoreovirus infection in Atlantic salmon (Salmo salar) protects against subsequent challenge with infectious hematopoietic necrosis virus (IHNV) |
title_sort |
piscine orthoreovirus infection in atlantic salmon (salmo salar) protects against subsequent challenge with infectious hematopoietic necrosis virus (ihnv) |
publisher |
BioMed Central |
publishDate |
2018 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5850924/ http://www.ncbi.nlm.nih.gov/pubmed/29534748 https://doi.org/10.1186/s13567-018-0524-z |
geographic |
Pacific |
geographic_facet |
Pacific |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5850924/ http://www.ncbi.nlm.nih.gov/pubmed/29534748 http://dx.doi.org/10.1186/s13567-018-0524-z |
op_rights |
© The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
op_rightsnorm |
CC0 PDM CC-BY |
op_doi |
https://doi.org/10.1186/s13567-018-0524-z |
container_title |
Veterinary Research |
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49 |
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1 |
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1766359899490484224 |