Antarctic Krill Oil Diet Protects against Lipopolysaccharide-Induced Oxidative Stress, Neuroinflammation and Cognitive Impairment
Oxidative stress and neuroinflammation are implicated in the development and pathogenesis of Alzheimer’s disease (AD). Here, we investigated the anti-inflammatory and antioxidative effects of krill oil. Oil from Euphausia superba (Antarctic krill), an Antarctic marine species, is rich in eicosapenta...
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ftpubmed:oai:pubmedcentral.nih.gov:5751157 2023-05-15T13:51:51+02:00 Antarctic Krill Oil Diet Protects against Lipopolysaccharide-Induced Oxidative Stress, Neuroinflammation and Cognitive Impairment Choi, Ji Yeon Jang, Jun Sung Son, Dong Ju Im, Hyung-Sik Kim, Ji Yeong Park, Joung Eun Choi, Won Rak Han, Sang-Bae Hong, Jin Tae 2017-11-28 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751157/ http://www.ncbi.nlm.nih.gov/pubmed/29182579 https://doi.org/10.3390/ijms18122554 en eng MDPI http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751157/ http://www.ncbi.nlm.nih.gov/pubmed/29182579 http://dx.doi.org/10.3390/ijms18122554 © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). CC-BY Article Text 2017 ftpubmed https://doi.org/10.3390/ijms18122554 2018-01-14T01:15:01Z Oxidative stress and neuroinflammation are implicated in the development and pathogenesis of Alzheimer’s disease (AD). Here, we investigated the anti-inflammatory and antioxidative effects of krill oil. Oil from Euphausia superba (Antarctic krill), an Antarctic marine species, is rich in eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). We examined whether krill oil diet (80 mg/kg/day for one month) prevents amyloidogenesis and cognitive impairment induced by intraperitoneal lipopolysaccharide (LPS) (250 µg/kg, seven times daily) injections in AD mice model and found that krill oil treatment inhibited the LPS-induced memory loss. We also found that krill oil treatment inhibited the LPS-induced expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) and decreased reactive oxygen species (ROS) and malondialdehyde levels. Krill oil also suppresses IκB degradation as well as p50 and p65 translocation into the nuclei of LPS-injected mice brain cells. In association with the inhibitory effect on neuroinflammation and oxidative stress, krill oil suppressed amyloid beta (1–42) peptide generation by the down-regulating APP and BACE1 expression in vivo. We found that eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) (50 and 100 µM) dose-dependently decreased LPS-induced nitric oxide and ROS generation, and COX-2 and iNOS expression as well as nuclear factor-κB activity in cultured microglial BV-2 cells. These results suggest that krill oil ameliorated impairment via anti-inflammatory, antioxidative, and anti-amyloidogenic mechanisms. Text Antarc* Antarctic Antarctic Krill Euphausia superba PubMed Central (PMC) Antarctic International Journal of Molecular Sciences 18 12 2554 |
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Article Choi, Ji Yeon Jang, Jun Sung Son, Dong Ju Im, Hyung-Sik Kim, Ji Yeong Park, Joung Eun Choi, Won Rak Han, Sang-Bae Hong, Jin Tae Antarctic Krill Oil Diet Protects against Lipopolysaccharide-Induced Oxidative Stress, Neuroinflammation and Cognitive Impairment |
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Oxidative stress and neuroinflammation are implicated in the development and pathogenesis of Alzheimer’s disease (AD). Here, we investigated the anti-inflammatory and antioxidative effects of krill oil. Oil from Euphausia superba (Antarctic krill), an Antarctic marine species, is rich in eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). We examined whether krill oil diet (80 mg/kg/day for one month) prevents amyloidogenesis and cognitive impairment induced by intraperitoneal lipopolysaccharide (LPS) (250 µg/kg, seven times daily) injections in AD mice model and found that krill oil treatment inhibited the LPS-induced memory loss. We also found that krill oil treatment inhibited the LPS-induced expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) and decreased reactive oxygen species (ROS) and malondialdehyde levels. Krill oil also suppresses IκB degradation as well as p50 and p65 translocation into the nuclei of LPS-injected mice brain cells. In association with the inhibitory effect on neuroinflammation and oxidative stress, krill oil suppressed amyloid beta (1–42) peptide generation by the down-regulating APP and BACE1 expression in vivo. We found that eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) (50 and 100 µM) dose-dependently decreased LPS-induced nitric oxide and ROS generation, and COX-2 and iNOS expression as well as nuclear factor-κB activity in cultured microglial BV-2 cells. These results suggest that krill oil ameliorated impairment via anti-inflammatory, antioxidative, and anti-amyloidogenic mechanisms. |
format |
Text |
author |
Choi, Ji Yeon Jang, Jun Sung Son, Dong Ju Im, Hyung-Sik Kim, Ji Yeong Park, Joung Eun Choi, Won Rak Han, Sang-Bae Hong, Jin Tae |
author_facet |
Choi, Ji Yeon Jang, Jun Sung Son, Dong Ju Im, Hyung-Sik Kim, Ji Yeong Park, Joung Eun Choi, Won Rak Han, Sang-Bae Hong, Jin Tae |
author_sort |
Choi, Ji Yeon |
title |
Antarctic Krill Oil Diet Protects against Lipopolysaccharide-Induced Oxidative Stress, Neuroinflammation and Cognitive Impairment |
title_short |
Antarctic Krill Oil Diet Protects against Lipopolysaccharide-Induced Oxidative Stress, Neuroinflammation and Cognitive Impairment |
title_full |
Antarctic Krill Oil Diet Protects against Lipopolysaccharide-Induced Oxidative Stress, Neuroinflammation and Cognitive Impairment |
title_fullStr |
Antarctic Krill Oil Diet Protects against Lipopolysaccharide-Induced Oxidative Stress, Neuroinflammation and Cognitive Impairment |
title_full_unstemmed |
Antarctic Krill Oil Diet Protects against Lipopolysaccharide-Induced Oxidative Stress, Neuroinflammation and Cognitive Impairment |
title_sort |
antarctic krill oil diet protects against lipopolysaccharide-induced oxidative stress, neuroinflammation and cognitive impairment |
publisher |
MDPI |
publishDate |
2017 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751157/ http://www.ncbi.nlm.nih.gov/pubmed/29182579 https://doi.org/10.3390/ijms18122554 |
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Antarctic |
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Antarctic |
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Antarc* Antarctic Antarctic Krill Euphausia superba |
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Antarc* Antarctic Antarctic Krill Euphausia superba |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751157/ http://www.ncbi.nlm.nih.gov/pubmed/29182579 http://dx.doi.org/10.3390/ijms18122554 |
op_rights |
© 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
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CC-BY |
op_doi |
https://doi.org/10.3390/ijms18122554 |
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International Journal of Molecular Sciences |
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18 |
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12 |
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2554 |
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1766255890009161728 |