Lack of acclimatization to chronic hypoxia in humans in the Antarctica
The study was carried out at Concordia Station (Antarctic Plateau). The aim was to investigate the respiratory and haematological responses to hypoxia in healthy subjects living at constant altitude. Thirteen men and women (34.1 ± 3.1 years) were exposed for 10 months to hypobaric hypoxia (oxygen le...
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ftpubmed:oai:pubmedcentral.nih.gov:5741743 2023-05-15T13:51:51+02:00 Lack of acclimatization to chronic hypoxia in humans in the Antarctica Porcelli, Simone Marzorati, Mauro Healey, Beth Terraneo, Laura Vezzoli, Alessandra Bella, Silvia Della Dicasillati, Roberto Samaja, Michele 2017-12-22 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741743/ http://www.ncbi.nlm.nih.gov/pubmed/29273712 https://doi.org/10.1038/s41598-017-18212-1 en eng Nature Publishing Group UK http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741743/ http://www.ncbi.nlm.nih.gov/pubmed/29273712 http://dx.doi.org/10.1038/s41598-017-18212-1 © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. CC-BY Article Text 2017 ftpubmed https://doi.org/10.1038/s41598-017-18212-1 2018-01-07T01:28:09Z The study was carried out at Concordia Station (Antarctic Plateau). The aim was to investigate the respiratory and haematological responses to hypoxia in healthy subjects living at constant altitude. Thirteen men and women (34.1 ± 3.1 years) were exposed for 10 months to hypobaric hypoxia (oxygen level equivalent to 3800 m asl). These unique conditions enable a greater accuracy of monitoring human responses to chronic hypoxia than can be achieved elsewhere. Blood haemoglobin and erythropoietin concentrations were determined at sea level (Pre), and after 3, 7, 20, 90 and 300 days at altitude. Blood gas analysis, base excess and arterial oxygen saturation were measured at Pre, and after 150 and 300 days at altitude. Erythropoietin returned quickly to baseline level after a transient increase in the first days. Blood haemoglobin concentration started increasing at day 7 and remained markedly higher for the entire duration of the mission. At day 150 the blood carbon dioxide partial pressure was markedly reduced, and consequently blood pH remained higher at negative base excess until day 300. The arterial oxygen saturation remained lower than Pre throughout. In conclusion, humans display little capacity of hypoxia acclimatization even after ten months of constant exposure to low oxygen partial pressure. Text Antarc* Antarctic Antarctica PubMed Central (PMC) Antarctic Concordia Station ENVELOPE(123.333,123.333,-75.100,-75.100) Scientific Reports 7 1 |
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Article Porcelli, Simone Marzorati, Mauro Healey, Beth Terraneo, Laura Vezzoli, Alessandra Bella, Silvia Della Dicasillati, Roberto Samaja, Michele Lack of acclimatization to chronic hypoxia in humans in the Antarctica |
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The study was carried out at Concordia Station (Antarctic Plateau). The aim was to investigate the respiratory and haematological responses to hypoxia in healthy subjects living at constant altitude. Thirteen men and women (34.1 ± 3.1 years) were exposed for 10 months to hypobaric hypoxia (oxygen level equivalent to 3800 m asl). These unique conditions enable a greater accuracy of monitoring human responses to chronic hypoxia than can be achieved elsewhere. Blood haemoglobin and erythropoietin concentrations were determined at sea level (Pre), and after 3, 7, 20, 90 and 300 days at altitude. Blood gas analysis, base excess and arterial oxygen saturation were measured at Pre, and after 150 and 300 days at altitude. Erythropoietin returned quickly to baseline level after a transient increase in the first days. Blood haemoglobin concentration started increasing at day 7 and remained markedly higher for the entire duration of the mission. At day 150 the blood carbon dioxide partial pressure was markedly reduced, and consequently blood pH remained higher at negative base excess until day 300. The arterial oxygen saturation remained lower than Pre throughout. In conclusion, humans display little capacity of hypoxia acclimatization even after ten months of constant exposure to low oxygen partial pressure. |
format |
Text |
author |
Porcelli, Simone Marzorati, Mauro Healey, Beth Terraneo, Laura Vezzoli, Alessandra Bella, Silvia Della Dicasillati, Roberto Samaja, Michele |
author_facet |
Porcelli, Simone Marzorati, Mauro Healey, Beth Terraneo, Laura Vezzoli, Alessandra Bella, Silvia Della Dicasillati, Roberto Samaja, Michele |
author_sort |
Porcelli, Simone |
title |
Lack of acclimatization to chronic hypoxia in humans in the Antarctica |
title_short |
Lack of acclimatization to chronic hypoxia in humans in the Antarctica |
title_full |
Lack of acclimatization to chronic hypoxia in humans in the Antarctica |
title_fullStr |
Lack of acclimatization to chronic hypoxia in humans in the Antarctica |
title_full_unstemmed |
Lack of acclimatization to chronic hypoxia in humans in the Antarctica |
title_sort |
lack of acclimatization to chronic hypoxia in humans in the antarctica |
publisher |
Nature Publishing Group UK |
publishDate |
2017 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741743/ http://www.ncbi.nlm.nih.gov/pubmed/29273712 https://doi.org/10.1038/s41598-017-18212-1 |
long_lat |
ENVELOPE(123.333,123.333,-75.100,-75.100) |
geographic |
Antarctic Concordia Station |
geographic_facet |
Antarctic Concordia Station |
genre |
Antarc* Antarctic Antarctica |
genre_facet |
Antarc* Antarctic Antarctica |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741743/ http://www.ncbi.nlm.nih.gov/pubmed/29273712 http://dx.doi.org/10.1038/s41598-017-18212-1 |
op_rights |
© The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1038/s41598-017-18212-1 |
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Scientific Reports |
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7 |
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