Genome-Wide Association Study of Psychosis Proneness in the Finnish Population
The current study examined quantitative measures of psychosis proneness in a nonpsychotic population, in order to elucidate their underlying genetic architecture and to observe if there is any commonality to that already detected in the studies of individuals with overt psychotic conditions, such as...
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ftpubmed:oai:pubmedcentral.nih.gov:5737890 2023-05-15T17:42:41+02:00 Genome-Wide Association Study of Psychosis Proneness in the Finnish Population Ortega-Alonso, Alfredo Ekelund, Jesper Sarin, Antti-Pekka Miettunen, Jouko Veijola, Juha Järvelin, Marjo-Riitta Hennah, William 2017-10 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737890/ http://www.ncbi.nlm.nih.gov/pubmed/28525603 https://doi.org/10.1093/schbul/sbx006 en eng Oxford University Press http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737890/ http://www.ncbi.nlm.nih.gov/pubmed/28525603 http://dx.doi.org/10.1093/schbul/sbx006 © The Author 2017. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oup.com Regular Articles Text 2017 ftpubmed https://doi.org/10.1093/schbul/sbx006 2018-10-07T00:20:19Z The current study examined quantitative measures of psychosis proneness in a nonpsychotic population, in order to elucidate their underlying genetic architecture and to observe if there is any commonality to that already detected in the studies of individuals with overt psychotic conditions, such as schizophrenia and bipolar disorder. Heritability, univariate and multivariate genome-wide association (GWAs) tests, including a series of comprehensive gene-based association analyses, were developed in 4269 nonpsychotic persons participating in the Northern Finland Birth Cohort 1966 study with information on the following psychometric measures: Hypomanic Personality, Perceptual Aberration, Physical and Social Anhedonia (also known as Chapman’s Schizotypia scales), and Schizoidia scale. Genome-wide genetic data was available for ~9.84 million SNPs. Heritability estimates ranged from 16% to 27%. Phenotypic, genetic and environmental correlations ranged from 0.04–0.43, 0.25–0.73, and 0.12–0.43, respectively. Univariate GWAs tests revealed an intronic SNP (rs12449097) at the TMC7 gene (16p12.3) that significantly associated (P = 3.485 × 10–8) with the hypomanic scale. Bivariate GWAs tests including the hypomanic and physical anhedonia scales suggested a further borderline significant SNP (rs188320715; P-value = 5.261 × 10–8, ~572 kb downstream the ARID1B gene at 6q25.3). Gene-based tests highlighted 20 additional genes of which 5 had previously been associated to schizophrenia and/or bipolar disorder: CSMD1, CCDC141, SLC1A2, CACNA1C, and SNAP25. Altogether the findings explained from 3.7% to 14.1% of the corresponding trait heritability. In conclusion, this study provides preliminary genomic evidence suggesting that qualitatively similar biological factors may underlie different psychosis proneness measures, some of which could further predispose to schizophrenia and bipolar disorder. Text Northern Finland PubMed Central (PMC) Schizophrenia Bulletin 43 6 1304 1314 |
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Regular Articles Ortega-Alonso, Alfredo Ekelund, Jesper Sarin, Antti-Pekka Miettunen, Jouko Veijola, Juha Järvelin, Marjo-Riitta Hennah, William Genome-Wide Association Study of Psychosis Proneness in the Finnish Population |
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Regular Articles |
description |
The current study examined quantitative measures of psychosis proneness in a nonpsychotic population, in order to elucidate their underlying genetic architecture and to observe if there is any commonality to that already detected in the studies of individuals with overt psychotic conditions, such as schizophrenia and bipolar disorder. Heritability, univariate and multivariate genome-wide association (GWAs) tests, including a series of comprehensive gene-based association analyses, were developed in 4269 nonpsychotic persons participating in the Northern Finland Birth Cohort 1966 study with information on the following psychometric measures: Hypomanic Personality, Perceptual Aberration, Physical and Social Anhedonia (also known as Chapman’s Schizotypia scales), and Schizoidia scale. Genome-wide genetic data was available for ~9.84 million SNPs. Heritability estimates ranged from 16% to 27%. Phenotypic, genetic and environmental correlations ranged from 0.04–0.43, 0.25–0.73, and 0.12–0.43, respectively. Univariate GWAs tests revealed an intronic SNP (rs12449097) at the TMC7 gene (16p12.3) that significantly associated (P = 3.485 × 10–8) with the hypomanic scale. Bivariate GWAs tests including the hypomanic and physical anhedonia scales suggested a further borderline significant SNP (rs188320715; P-value = 5.261 × 10–8, ~572 kb downstream the ARID1B gene at 6q25.3). Gene-based tests highlighted 20 additional genes of which 5 had previously been associated to schizophrenia and/or bipolar disorder: CSMD1, CCDC141, SLC1A2, CACNA1C, and SNAP25. Altogether the findings explained from 3.7% to 14.1% of the corresponding trait heritability. In conclusion, this study provides preliminary genomic evidence suggesting that qualitatively similar biological factors may underlie different psychosis proneness measures, some of which could further predispose to schizophrenia and bipolar disorder. |
format |
Text |
author |
Ortega-Alonso, Alfredo Ekelund, Jesper Sarin, Antti-Pekka Miettunen, Jouko Veijola, Juha Järvelin, Marjo-Riitta Hennah, William |
author_facet |
Ortega-Alonso, Alfredo Ekelund, Jesper Sarin, Antti-Pekka Miettunen, Jouko Veijola, Juha Järvelin, Marjo-Riitta Hennah, William |
author_sort |
Ortega-Alonso, Alfredo |
title |
Genome-Wide Association Study of Psychosis Proneness in the Finnish Population |
title_short |
Genome-Wide Association Study of Psychosis Proneness in the Finnish Population |
title_full |
Genome-Wide Association Study of Psychosis Proneness in the Finnish Population |
title_fullStr |
Genome-Wide Association Study of Psychosis Proneness in the Finnish Population |
title_full_unstemmed |
Genome-Wide Association Study of Psychosis Proneness in the Finnish Population |
title_sort |
genome-wide association study of psychosis proneness in the finnish population |
publisher |
Oxford University Press |
publishDate |
2017 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737890/ http://www.ncbi.nlm.nih.gov/pubmed/28525603 https://doi.org/10.1093/schbul/sbx006 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737890/ http://www.ncbi.nlm.nih.gov/pubmed/28525603 http://dx.doi.org/10.1093/schbul/sbx006 |
op_rights |
© The Author 2017. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oup.com |
op_doi |
https://doi.org/10.1093/schbul/sbx006 |
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Schizophrenia Bulletin |
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43 |
container_issue |
6 |
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1304 |
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1314 |
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1766144586670931968 |